Epidemiology of hepatitis B and C virus infection in Central West Argentina

Villar, Lívia Melo; Paula, Vanessa Salete de; Lago, Bárbara Vieira do; Miguel, Juliana Custódio; Cruz, Helena Medina; Portilho, Moyra Machado; Marques, Vanessa Alves; Ravier, Roberto Pérez; Castro, Ivana Lo; Cuello, Héctor; Espul, Carlos

doi:10.1007/s00705-020-04540-7

Cited by 10 publications

(31 citation statements)

References 33 publications

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“…Overall, DBS and serum samples from 16,255 individuals were included: 13,742 (84.5%) adults, 560 (3.4%) 5-to 17-year old's and 2,082 (12.8%) less than five years old. Two studies reported antibodies against hepatitis A [14,15], nine hepatitis B [16][17][18][26][27][28]46,48,51], ten hepatitis C [19][20][21][22][26][27][28]37,46,48], eight HIV [23][24][25][26][27][28]46,50], three human papillomavirus (HPV) [29,30,37], three measles [31,32,42], three rubella [33,34,42], two syphilis [40,46], two H. pylori [35,47] and two malaria [38,49]. Twelve papers reported on Chagas disease [35], Epstein-Barr virus [36], HPV, H. pylori, hepatitis C and polyomavirus [37], Strong...…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Twelve papers reported on Chagas disease [35], Epstein-Barr virus [36], HPV, H. pylori, hepatitis C and polyomavirus [37], Strongyloidiasis [39], pertussis [41], hepatitis E [56], Vibrio cholera [2], measles, mumps and rubella [42], tuberculosis and cytomegalovirus [43], toxoplasmosis [44], trypanosoma [45], Covid-19 [52], respectively. Twelve studies were conducted in Europe [14,18,21,27,29,30,35,[41][42][43]50,52], four in North America [19,20,32,36], eleven in South America [15][16][17]22,24,34,38,39,48,49,51], seven in Africa [23,25,26,31,40,44,45] and five in Asia [28,33,…”

Section: Study Characteristicsmentioning

confidence: 99%

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Reliability of dried blood spot (DBS) cards in antibody measurement: A systematic review

et al. 2021

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Background Increasingly, vaccine efficacy studies are being recommended in low-and-middle-income countries (LMIC), yet often facilities are unavailable to take and store infant blood samples correctly. Dried blood spots (DBS), are useful for collecting blood from infants for diagnostic purposes, especially in low-income settings, as the amount of blood required is miniscule and no refrigeration is required. Little is known about their utility for antibody studies in children. This systematic review aims to investigate the correlation of antibody concentrations against infectious diseases in DBS in comparison to serum or plasma samples that might inform their use in vaccine clinical trials. Methods and findings We searched MEDLINE, Embase and the Cochrane library for relevant studies between January 1990 to October 2020 with no language restriction, using PRISMA guidelines, investigating the correlation between antibody concentrations in DBS and serum or plasma samples, and the effect of storage temperature on DBS diagnostic performance. We included 40 studies in this systematic review. The antibody concentration in DBS and serum/plasma samples reported a good pooled correlation, (r2 = 0.86 (ranged 0.43 to 1.00)). Ten studies described a decline of antibody after 28 days at room temperature compared to optimal storage at -20°C, where antibodies were stable for up to 200 days. There were only five studies of anti-bacterial antibodies. Conclusions There is a good correlation between antibody concentrations in DBS and serum/plasma samples, supporting the wider use of DBS in vaccine and sero-epidemiological studies, but there is limited data on anti-bacterial antibodies. The correct storage of DBS is critical and may be a consideration for longer term storage.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Reliability of dried blood spot (DBS) cards in antibody measurement: A systematic review

et al. 2021

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“…Hepatitis C (HC) is the leading cause of chronic liver disease, which can progress to chronic hepatocellular carcinoma with a high level of economic burden [8][9][10][11][12][13][14]. HB has silent epidemiology, and it is a primary bloodborne infection worldwide [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

et al. 2021

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Objective Hepatitis B (HB) and C (HC) are two severe viral infectious diseases with a deleterious impact on global health. This study aimed to evaluate the prevalence of HB and HC in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study using immunological and molecular methods. Results The blood samples were obtained from 10,520 enrolled participants. Complete biochemical and hematological tests, as well as urine analysis, were assessed. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participant and HBeAg and anti-HBe antibodies for HB-positive patients were evaluated. Moreover, HB genomic DNA and HC genomic RNA were extracted from serum samples of HB-positive patients. The real-time PCR assay was employed to quantify the gene copies of hepatitis B and C viruses. HC genotyping was also performed. The prevalence of HB and HC was 0.24% (95% CI 0.16–0.35) and 0.11% (95% CI 0.06–0.19), respectively. Rural participants were significantly more HB-positive than the urban people (P = 0.045), while males were significantly more HC-positive than the females (P = 0.013). The prevalence of HB and HC in this area were lower than those of other geographical locations of Iran, which may be due to different lifestyles or other unknown reasons.

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“…The hepatitis C virus (HCV) is the leading cause of chronic liver disease, which can lead to chronic hepatocellular carcinoma with a high economic burden [7][8][9][10][11][12][13]. It has silent epidemiology and, at the same time, is a primary blood-borne infection worldwide [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

Mansour‐Ghanaei

Joukar

Naghipour

et al. 2020

Preprint

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Objective Hepatitis B (HBV) and C (HCV) viruses are two severe infectious diseases with a high global health impact. This study aimed to evaluate the prevalence of HBV and HCV in the Prospective Epidemiological Research Studies of the Iranian Adults (PERSIAN) Guilan Cohort Study through immunological and molecular methods. Results The blood samples were obtained from 10520 enrolled participants. Complete biochemical and hematological assessments plus urine analysis were done. The presence of HBsAg, anti-HBs, anti-HBc, and anti-HCV antibodies for all participants and HBeAg and anti-HBe antibody for HBV positive patients were evaluated. HBV genomic DNA and HCV genomic RNA were extracted from positive serum samples. The real-time PCR assay was done to quantify HBV and HCV genomes. HCV genotyping was also performed. The HBV and HCV prevalence was 0.24% (95% CI, 0.16% to 0.35%) and 0.11% (95% CI, 0.06% to 0.19%), respectively. Rural participants were significantly more HBV positive than urban peoples (P = 0.045) while male individuals were significantly more HCV positive than female participants (P = 0.013). Our detected HBV and HCV prevalence were lower than other cities/provinces of Iran, which may be due to lifestyle or other unknown reasons.

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Epidemiology of hepatitis B and C virus infection in Central West Argentina

Cited by 10 publications

References 33 publications

Reliability of dried blood spot (DBS) cards in antibody measurement: A systematic review

Reliability of dried blood spot (DBS) cards in antibody measurement: A systematic review

Epidemiologic profile of viral hepatitis B and C in North of Iran: results from PERSIAN Guilan Cohort Study (PGCS)

Epidemiologic profile of viral hepatitis B and C in North of Iran: Results from PERSIAN Guilan Cohort Study (PGCS)

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