Epidemiology of Helicobacter pylori among multiracial community in Northern Peninsular, Malaysia: effect of age across race and gender

Sasidharan, Sreenivasan; Lachumy, Subramanion Jo Thy; Ravichandran, Manickam; Latha, Lachimanan Yoga; Gegu, Surasa Rao Surya

doi:10.1016/s1995-7645(11)60037-0

Cited by 28 publications

(25 citation statements)

References 22 publications

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“…The former suggests an early exposure to H. pylori in the studied population, and the latter follows a typical increase in the frequency of H. pylori infection in humans as reported elsewhere [5, 10, 12]. In the present study, multivariate analysis of sociodemographic and behavioral characteristics of Tepehuanos showed that seropositivity to H. pylori was associated with low education (up to 6 years of education) (OR = 3.37; 95% CI: 1.13–10.00; P = 0.02) and laborer occupation (OR = 2.71; 95% CI: 1.14–6.42; P = 0.02).…”

Section: Discussionsupporting

confidence: 75%

Seroepidemiology ofHelicobacter pyloriInfection in Tepehuanos Aged 15 Years and Older in Durango, Mexico

Alvarado‐Esquivel

2013

Journal of Pathogens

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This study aimed to determine the seroepidemiology of Helicobacter pylori infection in Tepehuanos (an indigenous ethnic group living in rural Mexico). The prevalence of anti-Helicobacter pylori IgG antibodies was examined in 156 Tepehuanos in Durango State, Mexico, using an enzyme-linked immunoassay. In addition, sociodemographic, clinical, and behavioral characteristics of Tepehuanos associated with seropositivity were investigated. In total, 103 (66%) of the 156 participants (mean age 31.03 ± 16.71 years) had Helicobacter pylori IgG antibodies. Fifty-four (52.4%) of the 103 seropositive individuals had Helicobacter pylori IgG antibody levels higher than 100 U/mL. Males and females had comparable seroprevalence of Helicobacter pylori infection and Helicobacter pylori IgG antibody levels. The seroprevalence was significantly higher in women with pregnancies than those without this obstetric characteristic. Logistic regression showed that Helicobacter pylori infection was positively associated with low education (OR = 3.37; 95% CI: 1.13–10.00; P = 0.02) and laborer occupation (OR = 2.71; 95% CI: 1.14–6.42; P = 0.02). This is the first report of seroprevalence and contributing factors for Helicobacter pylori infection in Tepehuanos and of the association of Helicobacter pylori infection with laborer occupation. Results warrants further research.

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Section: Discussionsupporting

confidence: 75%

Seroepidemiology ofHelicobacter pyloriInfection in Tepehuanos Aged 15 Years and Older in Durango, Mexico

Alvarado‐Esquivel

2013

Journal of Pathogens

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“…To the best of my knowledge, no previous serosurvey of H. pylori infection had explored the seroprevalence at a municipality level. Other putative factors associated with H. pylori infection including age (3, 16, 34), low educational level (35), socioeconomic status (3, 25), laborer occupation (27), and crowding (35) were not found associated with H. pylori seropositivity in the present study.…”

Section: Discussioncontrasting

confidence: 65%

Seroepidemiology of Toxoplasma gondii Infection in Pregnant Women in Rural Durango, Mexico

Alvarado‐Esquivel

Torres-Castorena

Liesenfeld

et al. 2009

Journal of Parasitology

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The epidemiology of Toxoplasma gondii infection in pregnant women in rural Mexico is largely unknown. The seroepidemiology of T. gondii infection in 439 pregnant women from 9 communities in rural Durango State, Mexico was investigated. Using commercial enzyme-linked immunoassays, sera were tested for T. gondii IgG, IgM, and avidity antibodies. Prevalences of T. gondii IgG antibodies in the communities varied from 0% to 20%. Overall, 36 (8.2%) of the 439 women had IgG T. gondii antibodies. Ten (2.3%) women had also T. gondii IgM antibodies; IgG avidity was high in all IgM-positive women, suggesting chronic infection. None of the women, however, had delivered a known T. gondii-infected child. The seroprevalence was significantly higher (P < 0.05) in women from low socio-economic conditions (14%) than in those with higher socio-economic status (6.6%). Multivariate analysis showed that T. gondii infection was associated with soil floors at home (adjusted OR = 2.89; 95% CI: 1.12-7.49). This is the first epidemiological study of T. gondii infection in pregnant women in rural Mexico.

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“…However [33,34], reported that the rate of infection with H. pylori, afflict men more frequently than women studied among 556 African-Americans. In a study reported by [35] the prevalence rate among males (18.9%) was significantly higher (p<0.001) than that among females (9.0%).…”

Section: Discussionmentioning

confidence: 77%

Prevalence of H. pylori strains harbouring cagA and iceA virulence genes in saudi patients with gastritis and peptic ulcer disease

Kadi¹,

Halawani²,

Abdelkader³

2014

Microbiol Discov

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Aim: The study is aimed to detect the presence of cagA, iceA1, and iceA2 virulence genes in H. pylori from gastric biopsies, and to deduce the correlation between these genotypes and the two clinical outcomes peptic ulcer disease (PUD), and gastritis. Materials and methods: Thirty three Saudi patients 15 males and 18 females, 20 to 90 years were assigned into two groups PUD and gastritis. Genomic DNAs were extracted from biopsy specimens and used to detect the presence of cagA, and iceA genes by PCR typing system. Fisher's and Phi coefficient association tests were used for statistical analysis. Results: Genotyping show that both cagA and iceA genes were amplified from 27 specimens (81.7%). The prevalence of cagA+ and cagA-genotypes or iceA+ and iceA-genotypes did not differ significantly between males and females (p=0.070). Within the PUD and gastritis groups, the percentages of specimens positive for cagA gene were 76.9 % and 85 %, while those positive for iceA+ were 92.3% and 75% respectively. All cagA+/iceA+ combined genotypes was statically correlated with peptic ulcer (77%). This correlation was not observed within H. pylori specimens typed from gastritis. Patients with either PUD or gastritis were most likely infected by several strains of H. pylori. Conclusion: Different strains of H. pylori have virulent genotypes evidenced by PCR-based genotyping from biopsy specimens at a reasonable cost and time. These virulence strains spread at Taif province, may result in sever clinical outcomes such as ulcers which may be developed to cancer, the situation which necessitates further studies.

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Epidemiology of Helicobacter pylori among multiracial community in Northern Peninsular, Malaysia: effect of age across race and gender

Abstract: The overall prevalence of H. pylori did increase with age group across ethnicity and gender, in Northern Peninsular Malaysia.

Cited by 28 publications

References 22 publications

Seroepidemiology ofHelicobacter pyloriInfection in Tepehuanos Aged 15 Years and Older in Durango, Mexico

Seroepidemiology ofHelicobacter pyloriInfection in Tepehuanos Aged 15 Years and Older in Durango, Mexico

Seroepidemiology of Toxoplasma gondii Infection in Pregnant Women in Rural Durango, Mexico

Prevalence of H. pylori strains harbouring cagA and iceA virulence genes in saudi patients with gastritis and peptic ulcer disease

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