Epidemiology of Gastrointestinal Stromal Tumors in a Defined Canadian Health Region: A Population-Based Study

Yan, Brian; Kaplan, Gilaad G.; Urbanski, Stefan J.; Nash, Carla; Beck, Paul L.

doi:10.1177/1066896907306967

Cited by 30 publications

(31 citation statements)

References 33 publications

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“…While 20% are asymptomatic and the tumors are detected incidentally, 10% of the lesions are detected only at autopsy. Symptoms and signs are not disease specific, they are related more to the site of the tumor [6,7,16] . Bleeding (30%-40%) comprises the most common symptom after vague abdominal discomfort (60%-70%).…”

Section: Clinical Presentationmentioning

confidence: 99%

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A gist of gastrointestinal stromal tumors: A review

Rammohan¹,

Sathyanesan²,

Rajendran³

et al. 2012

WJGO

153

193

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enchymal tumors. Both traditional and minimally invasive surgery are used to remove these tumors with minimal morbidity and excellent perioperative outcomes. The revolutionary use of specific, molecularlytargeted therapies, such as imatinib mesylate, reduces the frequency of disease recurrence when used as an adjuvant following complete resection. Neoadjuvant treatment with these agents appears to stabilize disease in the majority of patients and may reduce the extent of surgical resection required for subsequent complete tumor removal. The important interplay between the molecular genetics of GIST and responses to targeted therapeutics serves as a model for the study of targeted therapies in other solid tumors. This review summarizes our current knowledge and recent advances regarding the histogenesis, pathology, molecular biology, the basis for the novel targeted cancer therapy and current evidence based management of these unique tumors. AbstractGastrointestinal stromal tumors (GISTs)

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Section: Clinical Presentationmentioning

confidence: 99%

“…Distant metastases most commonly occur in GISTs of the peritoneum, omentum, mesentery and the liver. GISTs have a high tendency to seed and hence intraperitoneal or even scar metastases are known to occur [6,7,16] .…”

Section: Clinical Presentationmentioning

confidence: 99%

A gist of gastrointestinal stromal tumors: A review

Rammohan¹,

Sathyanesan²,

Rajendran³

et al. 2012

WJGO

153

193

View full text Add to dashboard Cite

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“…Single or small clusters of cells with marked cytological atypia (pleomorphic nuclei with prominent nucleoli) and architectural atypia (necrosis, cribriforming) [34] Spindle cells with eosinophilic cytoplasm arranged in whirls [26] Symptom Incidental (%) 19% 20% [38] 30% [32] Weight loss (%) 8% 62% [35] 32% [33] GI bleeding or anemia (%) 16% 20% [35] 72% [36] Pain or fullness (%) 27% 70% [35] 32% [36] 5-year survival rate 100% 27.1% [29] 35% [30] Curative resection 100% 41.2% [31] 54% [30] ing surgical resection have been reported. In summary, GCP is a rare gastric submucosal tumor that is confused with other more common gastric pathologies.…”

Section: Discussionmentioning

confidence: 99%

Gastritis Cystica Profunda: A Rare Gastric Tumor Masquerading as a Malignancy

Laratta¹,

Buhtoiarova²,

Sparber³

et al. 2012

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Introduction: Gastritis cystica profunda (GCP) is a rare tumor which occurs more commonly in patients with prior gastric surgery. The nonspecific symptoms and radiographic appearance of this tumor mimic that of other hyperproliferative conditions making diagnosis difficult without definitive surgical resection. This report provides a comprehensive review of GCP and all GCP cases reported to date. Methods: A comprehensive literature search (1972-2011) was conducted with all reported GCP cases analyzed. Keywords searched included gastritis cystica profunda, submucosal cysts of the stomach, and heterotopic submucosal gastric glands. Results: Thirty-seven GCP cases have been reported since 1972, which includes 29 (78%) men and 8 (21%) women (M:F ratio, 3.6:1). The overall mean age was 60.5 years (range, 39 -81 years) with 55.6 years (range, 39 -79) and 62.2 years (range, 39 -81 years) in women and men, respectively. 65% (N = 24) had prior gastric surgery. 62% (N = 23) of GCP tumors were located in the body; 24% (N = 9) in the fundus; 8% (N = 3) in the antrum; or 6% (N = 2) in the cardia of the stomach. GCP was an incidental finding in 19% of patients. Complete excision was performed most often (73%) followed by endomucosal resection (18%), and polypectomy (4.5%). One patient underwent surveillance (4.5%). Conclusions: GCP is a rare gastric tumor, which is difficult to diagnose preoperatively and masquerades as a malignancy. GCP is more common in men and typically presents with nonspecific symptoms. Although a benign lesion, GCP may represent an intermediate histology in the malignant progression to gastric neoplasia. To date, there have been no reports of local recurrence or distant metastasis following definitive surgical excision, which remains the standard of care.

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“…It has been established that cancer cases are higher in males than females (Huguley, 1999;Yan et al, 2008). Evidence from studies of populations that migrated from one geographic area to another suggests that these variations are due to differences in lifestyle rather than ethnic origin.…”

Section: Introductionmentioning

confidence: 99%

“…These ranges from dietary habits, social habits, environmental factors, infectious agents like viruses, bacteria and other parasites have been associated with most cancers (Cuzick, 2001;Yan et al, 2008;Agarwal et al, 2012). Chemicals, hormones, X-rays and ultra-violent irradiations have been positively known to cause tumors (Griffith, 2001).…”

Section: Causes Of Cancermentioning

confidence: 99%