Epidemiology of fungaemia in Sweden: A nationwide retrospective observational survey

Klingspor, Lena; Ullberg, Måns; Rydberg, Johan; Kondori, Nahid; Serrander, Lena; Swanberg, Jonas; Nilsson, Kenneth; Bengtén, Cecilia Jendle; Johansson, Marcus; Granlund, Margareta; Tornqvist, Ewa Wigaeus; Nyberg, Anders; Kindlund, Karin; Ygge, Minna; Kartout-Boukdir, Dalila; Toepfer, Michael; Hålldin, E; Kahlmeter, Gunnar; Özenci, Volkan

doi:10.1111/myc.12816

Cited by 22 publications

(38 citation statements)

References 26 publications

(36 reference statements)

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“…In a previous study, we reported the incidence of candidaemia as 4.2/100 000 inhabitants in 2005‐2006 . We reported recently an increased incidence . The incidence of candidemia has been increasing worldwide.…”

Section: Discussionmentioning

confidence: 92%

“…Candidemia data were derived from the latest data from national epidemiological fungemia surveillance programme. The incidence of candidemia is 4.7/100 000 individuals in Sweden . The number of cases with intra‐abdominal candidiasis ( Candida peritonitis), usually a postsurgical complication was also seen only in intensive care unit at a rate of 50% of the candidemia cases based on previous study .…”

Section: Methodsmentioning

confidence: 93%

“…The number of cases with intra‐abdominal candidiasis ( Candida peritonitis), usually a postsurgical complication was also seen only in intensive care unit at a rate of 50% of the candidemia cases based on previous study . Data on Cryptococcus meningitis were retrieved from all laboratories in Sweden . Infections due to Mucorales and P jirovecii were retrieved from Karolinska University Laboratory and cover only 25% of Swedish population.…”

Section: Methodsmentioning

confidence: 99%

“…Knowledge of the local epidemiology of invasive fungal infections is essential for effective infection control programs and antifungal stewardship . The epidemiology of fungal infections in Sweden is largely unknown, except for candidemia . The aim of this study was to estimate the annual burden of fungal infections in Sweden using data mainly from 2016.…”

Section: Introductionmentioning

confidence: 99%

“…7 The epidemiology of fungal infections in Sweden is largely unknown, except for candidemia. 8 The aim of this study was to estimate the annual burden of fungal infections in Sweden using data mainly from 2016.…”

Section: Introductionmentioning

confidence: 99%

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Estimated burden of fungal infections in Sweden

Özenci

Klingspor

Ullberg

et al. 2019

Mycoses

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Summary The aim of this study was to estimate the annual burden of fungal infections in Sweden using data mainly from 2016. Data on specific populations were obtained from Swedish national data registries. Annual incidence and prevalence of fungal disease was calculated based on epidemiological studies. Data on infections due to Cryptococcus sp., Mucorales, Histoplasma capsulatum, Coccidioides immitis and Pneumocystis jirovecii were retrieved from Karolinska University Laboratory and covers only 25% of Swedish population. In 2016, the population of Sweden was 9 995 153 (49.8% female). The overall burden of fungal infections was 1 713 385 (17 142/100 000). Superficial fungal infections affect 1 429 307 people (1429/100 000) based on Global Burden of Disease 14.3% prevalence. Total serious fungal infection burden was 284 174 (2843/100 000) in 2016. Recurrent Candida vulvovaginitis is common; assuming a 6% prevalence in women. Prevalence of allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitisation were estimated to be 20 095 and 26 387, respectively. Similarly, chronic pulmonary aspergillosis was estimated to affect 490 patients after tuberculosis, sarcoidosis and other conditions. Candidemia incidence was estimated to be 500 in 2016 (4.7/100 000) and invasive aspergillosis 295 (3.0/100 000). In Stockholm area, Mucorales were reported in three patients in 2015, while Cryptococcus spp. were reported in two patients. In 2016, there were 297 patients PCR positive for P jirovecii. The present study shows that the overall burden of fungal infections in Sweden is high and affects 17% of the population. The morbidity, mortality and the healthcare‐related costs due to fungal infections warrant further studies.

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Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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