Epidemiology of food allergy and food-induced anaphylaxis

Koplin, Jennifer J.; Mills, E. N. Clare; Allen, Katrina J.

doi:10.1097/aci.0000000000000196

Cited by 59 publications

(35 citation statements)

References 45 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Annually, food allergy results in costs to the US healthcare system of approximately $24.8 billion 6 . In addition, the global prevalence of all food allergy seems to be increasing 7 . Between 1997 and 2007, the self-reported prevalence of food allergy in children under 18 years old in the United States increased by 18% to an estimated prevalence of 3.9% 8 , and prevalence had reached ~5% by 2011 (REF.…”

mentioning

confidence: 99%

Food allergy: immune mechanisms, diagnosis and immunotherapy

2016

View full text Add to dashboard Cite

Food allergy is a pathological, potentially deadly, immune reaction triggered by normally innocuous food protein antigens. The prevalence of food allergies is rising and the standard of care is not optimal, consisting of food-allergen avoidance and treatment of allergen-induced systemic reactions with adrenaline. Thus, accurate diagnosis, prevention and treatment are pressing needs, research into which has been catalysed by technological advances that are enabling a mechanistic understanding of food allergy at the cellular and molecular levels. We discuss the diagnosis and treatment of IgE-mediated food allergy in the context of the immune mechanisms associated with healthy tolerance to common foods, the inflammatory response underlying most food allergies, and immunotherapy-induced desensitization. We highlight promising research advances, therapeutic innovations and the challenges that remain.

show abstract

mentioning

confidence: 99%

Food allergy: immune mechanisms, diagnosis and immunotherapy

2016

View full text Add to dashboard Cite

show abstract

“…The global prevalence of all types of food allergy seems to be increasing . Food allergy prevalence has been found to be 6.7% in children .…”

Section: Discussionmentioning

confidence: 99%

Characteristics of persistent diaper dermatitis in children with food allergy

Celiksoy

Topal

Ökmen

et al. 2018

Pediatric Dermatology

View full text Add to dashboard Cite

Background/Objectives Diaper dermatitis is often caused by irritant contact occurring beneath the diaper of an infant, and it is aggravated by factors such as dampness, friction, urea, and feces. Food‐allergic patients are known to exhibit various skin lesions ranging from urticaria to eczema. This study aims to determine the relationship between persistent diaper dermatitis and food allergy. Methods A retrospective chart review was conducted of pediatric patients with a diagnosis of persistent diaper dermatitis between August 2015 and November 2017. Results The study included 157 patients diagnosed with persistent diaper dermatitis (67 male, 72 female; median age: 13 months). Diaper dermatitis was more common and included the whole perineum in children who had multiple food allergies (P = 0.001). In children with multiple food allergies, the course of diaper dermatitis was more severe, and the condition did not respond to topical treatment (P = 0.025). A longer elimination diet was required for patients with Type I reactions and persistent diaper dermatitis (P = 0.018). In patients with Type II and mixed reactions, diaper dermatitis was more diffuse and covered the whole perineum (P = 0.025). In patients with Type II and mixed reactions, diaper dermatitis was more severe and did not respond to topical treatment (P = 0.025). Conclusions Persistent diaper dermatitis lasting longer than a month may be associated with food allergy. The diaper rash may also be the only indicator of the food allergy. Elimination of the responsible food may allow these patients to recover from persistent diaper dermatitis.

show abstract

“…IgE-mediated FA has been previously identified as the main cause of anaphylaxis during childhood 18,19 . In this study, 40% of the patients had a history compatible with anaphylaxis, which is in line with previously obtained data 12 .…”

Section: Discussionmentioning

confidence: 99%

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Feuerhake

Aguilera-Insunza

Morales

et al. 2018

Rev. chil. pediatr.

View full text Add to dashboard Cite

Background: Food allergy (FA) is an entity of high and growing prevalence, which can be mediated by IgE or cellular immunity. It can have a wide range of symptoms and be triggered by multiple food antigens, which vary in different geographical areas. Objectives: To describe clinical characteristics of Chilean patients with IgE-mediated FA. Patients and Method: Retrospective review of patients with IgE-mediated FA treated at a tertiary healthcare center in Santiago, Chile, between 2006 and 2016. Demographic characteristics, clinical manifestations, and trigger foods were evaluated. Results: A total of 282 patients diagnosed with IgE-mediated FA were included. 89% had FA onset before 18 years of age and most of these before one year of age (median of age: one year; range: one month-55 years). The most common clinical manifestations were hives, angioedema, dyspnea, and vomiting. 40% had symptoms compatible with anaphylaxis. The foods most frequently involved were egg, cow's milk, peanut, shellfish, walnut, tomato, wheat, avocado, fish, and legumes. Egg, cow's milk, and peanut allergies were the most frequent at pediatric age, while seafood allergy was the most frequent among adults. Conclusion: Foods causing IgE-mediated FA in Chile were similar to those described in other countries, although the frequency of tomato and avocado allergy, which are unusual in international series, stands out. Anaphylaxis incidence was high, emphasizing the need for epinephrine autoinjectors in Chile.

show abstract

Epidemiology of food allergy and food-induced anaphylaxis

Cited by 59 publications

References 45 publications

Food allergy: immune mechanisms, diagnosis and immunotherapy

Food allergy: immune mechanisms, diagnosis and immunotherapy

Characteristics of persistent diaper dermatitis in children with food allergy

Caracterización clínica de pacientes chilenos con alergia alimentaria mediada por IgE

Contact Info

Product

Resources

About