Epidemiology of Food Allergy

Dunlop, Joan H.; Keet, Corinne A.

doi:10.1016/j.iac.2017.09.002

Cited by 126 publications

(87 citation statements)

References 72 publications

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“…As summarized in a recent review, 28 racial/ethnic disparities in allergic diseases, such as asthma 29 and eczema, 30 are well established, and data suggest that the burden of child food allergy may also be greater among the population of races/ethnicities other than white, non-Hispanic. 17 However, much less is known about such disparities in adult food allergy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Severity of Food Allergies Among US Adults

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Prevalence and Severity of Food Allergies Among US Adults

et al. 2019

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“…Although precise epidemiological data are lacking, it is clear that the prevalence of FA has increased significantly in the last two decades in Western countries, where rates of up to 10% have been documented among preschool children [5,6]. It is estimated that over 220 million people worldwide suffer from FA [3,[7][8][9][10]. However, making precise estimates is not easy due to the multiplicity and variable severity of clinical presentations, the difficulty in making objective diagnoses because of the strong psychological influences on the subjective perception of disease, and finally the complexity of the diagnostic tools.…”

Section: Epidemiologymentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

164

130

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The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show a global increase in the prevalence of food allergy all over the world and manifestations of food allergy appear increasingly frequent also in elderly subjects. Environmental and nutritional changes have partly changed the epidemiology of allergic reactions to foods and new food allergic syndromes have emerged in recent years. The deepening of the study of the intestinal microbiota has highlighted important mechanisms of immunological adaptation of the mucosal immune system to food antigens, leading to a revolution in the concept of immunological tolerance. As a consequence, new prevention models and innovative therapeutic strategies aimed at a personalized approach to the patient affected by food allergy are emerging. This review focuses on these new perspectives and their practical implications in the management of food allergy, providing an updated view of this complex pathology.

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“…IgE-mediated food allergy, particularly to peanuts (PN), is a major health problem, affecting 1%-4% of children in the United States and northern Europe. [1][2][3][4] Oral immunotherapy (OIT) is generally associated with favorable outcomes including attainment of sustained unresponsiveness (SU). [5][6][7][8][9] SU is most likely to occur in subjects who start with lower levels of peanut-sIgE and particularly in subjects who begin OIT at a younger age.…”

Section: Introductionmentioning

confidence: 99%

IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy

Dreskin

Germinaro

Reinhold³

et al. 2019

Pediatric Allergy Immunology

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Background: For patients with peanut allergy, there are currently no methods to predict who will develop sustained unresponsiveness (SU) after oral immunotherapy (OIT).Objective: Assess IgE binding to peanut (PN), Ara h 2, and specific linear epitopes of Ara h 2 as predictors of the important clinical parameters: eliciting dose threshold and attainment of SU following OIT. Methods: Samples and clinical data were collected from children undergoing OIT. PN-and Ara h 2-sIgE were quantified by ImmunoCAP ® . IgE binding to linear peptides of Ara h 2 and Ara h 6 was measured with peptide microarrays.Results: Values of PN-sIgE correlated with eliciting dose (P = .001) and with a higher likelihood of achieving SU (P < .0001), but these relationships were lost at higher values for PN-sIgE (≥14 kIU for eliciting dose and ≥35 kIU/L for SU). In subjects with PN-sIgE ≥ 14 kIU/L, binding of IgE to epitopes 5 and 6 of Ara h 2 was associated with a lower eliciting dose at baseline challenge (P < .001; P c < .02). In subjects with PN-sIgE ≥ 35 kIU/L, a combined model of IgE binding to epitopes 1, 5, and 6 with PN-sIgE was highly predictive of attainment of SU (AUC of 0.86; P = .0067). Conclusion:In young patients with peanut allergy, measurement of PN-sIgE and IgE binding to specific linear epitopes of Ara h 2 in baseline samples may allow stratification of patients regarding sensitivity to challenge and outcome of OIT. K E Y W O R D Sallergens, food allergy, IgE, immunotherapy, oral immunotherapy, peanut allergy, tolerance induction

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Epidemiology of Food Allergy

Cited by 126 publications

References 72 publications

Prevalence and Severity of Food Allergies Among US Adults

Prevalence and Severity of Food Allergies Among US Adults

New Perspectives in Food Allergy

IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy

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