Epidemiology of Esophageal Cancer

Haas, Joanna F.; Schottenfeld, David

doi:10.1007/978-1-4684-2442-3_7

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…Esophageal cancer, an important threat to the normal function of human digestion, ranks sixth among causes of cancer death. 1,2 There are various subtypes of esophageal cancer such as adenocarcinoma and squamous cell carcinoma. 3,4 The incidence and mortality of esophageal cancer ranks eighth and sixth in all malignant tumors in the world; approximately 456 000 new cases of esophageal cancer are diagnosed each year, and this malignancy has a severe effect on people's lives and health.…”

Section: Introductionmentioning

confidence: 99%

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Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

Sang

Chen

et al. 2020

Thoracic Cancer

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Background: Esophageal cancer (EC) is an important disease that threatens public health and safety. Although there are numerous treatment options for esophageal cancer including surgery, radiation therapy, and chemotherapy, these treatments have limited effects. Its morbidity and mortality vary widely among countries and regions. Esophageal cancer is classified into squamous cell carcinoma (ESCC) and esopheageal adenocarcinoma (EADC). Here, we examined the genetic susceptibility to ESCC in relation to functional single nucleotide polymorphisms (SNPs) in the long non-coding RNA (lncRNA) CASC8. Methods: To detect the susceptibility to ESCC in relation to functional polymorphisms in CASC8, a hypothesis-driven study was performed to identify CASC8 SNPs in 949 patients with ESCC and 1369 control subjects. Results: The CASC8 rs1562430 GG genotype was significantly associated with increased ESCC risk in men, patients younger than 63 years, non-smokers, and nondrinkers. Conclusions: CASC8 rs1562430 A > G may cause susceptibility to ESCC and CASC8 SNPs may play a vital role in ESCC risk, thereby serving as a potential biomarker for diagnosing ESCC. A larger sample size and multifactor information are needed to confirm these results.

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Section: Introductionmentioning

confidence: 99%

“…Esophageal cancer, an important threat to the normal function of human digestion, ranks sixth among causes of cancer death 1, 2 . There are various subtypes of esophageal cancer such as adenocarcinoma and squamous cell carcinoma 3, 4 .…”

Section: Introductionmentioning

confidence: 99%

Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

Sang

Chen

et al. 2020

Thoracic Cancer

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The epidemiology of cancer: An overview

Schottenfeld

1981

Cancer

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The contribution of cancer epidemiology to cancer prevention is in identifying risk factors, providing clues for understanding etiologic mechanisms, and in developing the scientific rationale for the effective application of preventive measures. Cancer mortality, incidence, and survival trends over 25 years (1950-1974) in the United States are reviewed for 12 selected sites in adult men and women. If both incidence and mortality for a specific cancer site remain unchanged or change proportionately over a period of years, no major change in survival should be anticipated. The patterns of occurrence and their etiologic implications are reviewed separately in American blacks and in children and young adults. The studies of geographic pathology and of various migrant populations have provided observational "experiments of nature" that have facilitated our understanding of cancer etiology by stimulating important paths of research.

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The Upper Gastrointestinal Tract, Esophagus, Stomach, Small Bowel, and Exocrine Pancreas

Gelb¹,

Straus²

1983

Geriatrics 2

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Epidemiology of Esophageal Cancer

Cited by 5 publications

References 57 publications

Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

The epidemiology of cancer: An overview

The Upper Gastrointestinal Tract, Esophagus, Stomach, Small Bowel, and Exocrine Pancreas

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