Epidemiology of Dysglycemia in Pregnant Oklahoma American Indian Women

Azar, Madona; Stoner, Julie A.; Dao, Hanh Dung; Stephens, Lancer; Goodman, Jean R.; Maynard, John; Lyons, Timothy J.

doi:10.1210/jc.2015-1779

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…One of the key features in our study was that we examined whether GDM recurrence was related to lipid profiles. It is of interest to mention that the first-trimester triglyceride concentration in subsequent pregnancy was significantly higher in the group with GDM recurrence, which agrees with the predictive value of the GDM occurrence [28] and progression to diabetes after GDM [29]. The triglyceride level was positively associated with the area under the postpartum glucose curve in women with prior GDM according to clinical research studies [30, 31].…”

Section: Discussionsupporting

confidence: 53%

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study

et al. 2019

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Background To investigate the frequency and risk factors for recurrent gestational diabetes mellitus (GDM) in Chinese primiparous women. Methods Case control study. We investigated primiparous women who experienced GDM complications and had a subsequent pregnancy in the same hospital from January, 2012 to January, 2017. Ultimately, 78 women with recurrent GDM and 64 women with no recurrence were included. Clinical characteristics and biochemical parameters such as fasting plasma glucose (FPG), oral glucose tolerance test (OGTT) and lipid profiles were collected from medical records. We used an independent t -test and Chi-square test or Fisher’s exact test to compare each variable. Univariate and multivariate logistic analyses were used to compute each odds ratio (OR) and 95% confidence interval (CI). Results The frequency of recurrent GDM was 55%. We found postprandial 1-h glucose at the 75-g OGTT was positively related to GDM recurrence, whereas first-trimester FPG in first pregnancy was negatively related. The first-trimester HbA1c value was higher in the group with GDM recurrence than in the group with no recurrence, though the difference was not significant. Moreover, the group with GDM recurrence manifested significantly higher first-trimester triglyceride concentrations in subsequent pregnancies; the adjusted ORs (95% CI) were 1.43 (1.09–1.87), 0.24 (0.10–0.63), 3.59 (0.93–13.88) and 1.89 (1.13–3.16). Conclusions GDM recurred in more than half of subsequent pregnancies. Women with lower first-trimester FPG and higher postprandial 1-h glucose in first pregnancy, and with higher first-trimester triglyceride in subsequent pregnancy were at increased risk for GDM recurrence.

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Section: Discussionsupporting

confidence: 53%

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study

et al. 2019

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“…A study from Trichy [ 52 ] recently reported GDM prevalence of 13.9 % in first trimester. Data from Oklahoma shows that among American Indians, prevalence of GDM and overt diabetes in first trimester was 24 % and 0.4 % respectively [ 53 ]. There is insufficient data from India on the prevalence of overt diabetes in the first trimester and hence the findings from this study are significant.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Gestational Diabetes Mellitus in urban and rural Tamil Nadu using IADPSG and WHO 1999 criteria (WINGS 6)

Bhavadharini

Mahalakshmi

Anjana

et al. 2016

Clin Diabetes Endocrinol

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BackgroundTo determine the prevalence of Gestational Diabetes Mellitus (GDM) in urban and rural Tamil Nadu in southern India, using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) and the World Health Organization (WHO) 1999 criteria for GDM.MethodsA total of 2121 pregnant women were screened for GDM from antenatal clinics in government primary health centres of Kancheepuram district (n = 520) and private maternity centres in Chennai city in Tamil Nadu (n = 1601) between January 2013 to December 2014. Oral glucose tolerance tests (OGTT) were done after an overnight fast of at least 8 h, using a 75 g glucose load and venous samples were drawn at 0, 1 and 2 h. GDM was diagnosed using both the IADPSG criteria as well as the WHO 1999 criteria for GDM.ResultsThe overall prevalence of GDM after adjusting for age, BMI, family history of diabetes and previous history of GDM was 18.5 % by IADPSG criteria with no significant urban/rural differences (urban 19.8 % vs rural 16.1 %, p = 0.46). Using the WHO 1999 criteria, the overall adjusted prevalence of GDM was 14.6 % again with no significant urban/rural differences (urban 15.9 % vs rural 8.9 %, p = 0.13).ConclusionThe prevalence of GDM by IADPSG was high both using IADPSG as well as WHO 1999 criteria with no significant urban/rural differences. This emphasizes the need for increasing awareness about GDM and for prevention of GDM in developing countries like India.Electronic supplementary materialThe online version of this article (doi:10.1186/s40842-016-0028-6) contains supplementary material, which is available to authorized users.

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“…Until sample sizes in available pregnancy cohorts with genetic information grow substantially, our collective ability to classify women with GDM via genetic approaches will be limited by our ignorance around genetic variants that influence glycemic physiology and diabetes risk in pregnancy. In addition, continued lack of ethnic diversity in genetic studies will limit the generalizability of such approaches to racial and ethnic minority women who are most likely to benefit, given the higher prevalence of GDM in Asian, Native American, and Latina women (68)(69)(70)(71).…”

Section: Maternal Genotype-based Approaches To Heterogeneity In Gdmmentioning

confidence: 99%

Defining Heterogeneity Among Women With Gestational Diabetes Mellitus

2020

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Attention to precision medicine in type 2 diabetes (T2D) has provided two favored approaches to subclassifying affected individuals and parsing heterogeneity apparent in this condition: phenotype-based and genotype-based. Gestational diabetes mellitus (GDM) shares phenotypic characteristics with T2D. However, unlike T2D, GDM emerges in the setting of profound pregnancy-related physiologic changes in glucose metabolism. T2D and GDM also share common genetic architecture, but there are likely to be unique genetic influences on pregnancy glycemic regulation that contribute to GDM. In this Perspective, we describe efforts to decipher heterogeneity in T2D and detail how we and others are applying approaches developed for T2D to the study of heterogeneity in GDM. Emerging results reveal the potential of phenotype-and genotype-based subclassification of GDM to deliver the promise of precision medicine to the obstetric population.

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Epidemiology of Dysglycemia in Pregnant Oklahoma American Indian Women

Abstract: Dysglycemia at some point during pregnancy was common among American Indian women. It was associated with features of insulin resistance and may confer long-term health risks for mother and child.

Cited by 10 publications

References 22 publications

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study

Frequency and risk factors for recurrent gestational diabetes mellitus in primiparous women: a case control study

Prevalence of Gestational Diabetes Mellitus in urban and rural Tamil Nadu using IADPSG and WHO 1999 criteria (WINGS 6)

Defining Heterogeneity Among Women With Gestational Diabetes Mellitus

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