Epidemiology of Diabetes in Bucharest

Abstract

An analysis of the last 20,000 newly diagnosed diabetic patients consecutively registered from 1 January 1981 to 6 June 1991 in the Bucharest Registry of Diabetes showed the following: (1) primary insulin-dependence (Type 1 diabetes) was encountered in only 7% of cases: the rest were Type 2 diabetic patients (8745:43.7% treated with diet alone and 9856:49.3% treated with diet and oral drugs); (2) low body weight (BMI < 25) was encountered in 81.7% of patients in the age group 0-20 years, while obesity (BMI > 27) was encountered in 75.7% of cases in the age group 41-65 years; (3) the overall annual incidence of the Type 1 diabetes for all ages was 5.7/100,000, lowest (1.3/100,000) in the age group 0-4 years and the highest 10.1/100,000) in the age group 65-69 years; (4) the overall annual incidence for the Type 2 diabetes was 76.3/100,000, the lowest (2.4/100,000) in the age group 20-24 years and the highest (261.4/100,000) in the age group 60-64 years. Studying the relationship between the onset of Type 1 diabetes mellitus and age, we did not observe the previously reported strong relationship, so that the distribution of Type 1 diabetes can be considered relatively uniform, with the exception of extreme ages. In conclusion, each year, about 1 in 1000 inhabitants of Bucharest are registered as having diabetes, the majority (93%) had type 2 and only 7% had Type 1 diabetes, one of the lowest incidence rates in Europe.

Low frequency of HLA DRB1*03 – DQB1*02 and DQB1*0302 haplotypes in Romania is consistent with the country's low incidence of Type I diabetes

“…The DNA samples were amplified in MJ Research PTC-225 thermal cyclers. The cycling parameters were 1 min at 96 C followed by 5 …”

“…with less than 4 cases per 100 000 person-years [4,5]. The role of genes in Type I diabetes is essential but the penetrance of susceptibility or resistance alleles is greatly influenced by environmental factors which have not yet been identified.…”

“…The incidence of Type I diabetes in Romania is one of the lowest in Europe [4,5]. Until now, no typing for Type I diabetes susceptibility genes in the Romanian population has been undertaken.…”

An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years

“…The disclosure of the factors that contribute to this variability may provide a better understanding of the pathogenesis of the disease. However, there are only a few papers regarding the epidemiology of type 1 diabetes mellitus in Romania, and these focus on children below 15 years of age (5,6).…”

A Challenge for the Autoimmune Diabetogenic Mechanisc in Type 1 Diabetes?

“…It happened that end of 2013 and the beginning of 2014 was marked by the publication of several controversial papers, which require commentary. Moreso as these papers were directly related to the mechanism of β-cell destruction associated with classical autoimmune T1D recorded not only in pediatric patients, but with a lower frequency also in older age (4).…”