Epidemiology of Diabetes and Diabetes Complications in the Elderly: An Emerging Public Health Burden

Corriere, Mark D.; Rooparinesingh, Nira; Kalyani, Rita R.

doi:10.1007/s11892-013-0425-5

Cited by 183 publications

(141 citation statements)

References 59 publications

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“…1,3,[24][25][26][27][28][29][30][31] Because diabetes and hypertension are leading causes of ESRD, we determined the contribution of the global rise in these diseases to the rise in prevalence and incidence of maintenance dialysis (Figures 4 and 5). Results among countries providing partial versus universal dialysis were remarkably similar.…”

Section: Factors For Change: Population Burden Of Diabetes Mellitus Amentioning

confidence: 99%

Maintenance Dialysis throughout the World in Years 1990 and 2010

Thomas

Wulf

Bikbov

et al. 2015

Journal of the American Society of Nephrology

170

137

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Rapidly rising global rates of chronic diseases portend a consequent rise in ESRD. Despite this, kidney disease is not included in the list of noncommunicable diseases (NCDs) targeted by the United Nations for 25% reduction by year 2025. In an effort to accurately report the trajectory and pattern of global growth of maintenance dialysis, we present the change in prevalence and incidence from 1990 to 2010. Data were extracted from the Global Burden of Disease 2010 epidemiologic database. The results are on the basis of an analysis of data from worldwide national and regional renal disease registries and detailed systematic literature review for years 1980-2010. Incidence and prevalence estimates of provision of maintenance dialysis from this database were updated using a negative binomial Bayesian metaregression tool for 187 countries. Results indicate substantial growth in utilization of maintenance dialysis in almost all world regions. Changes in population structure, changes in aging, and the worldwide increase in diabetes mellitus and hypertension explain a significant portion, but not all, of the increase because increased dialysis provision also accounts for a portion of the rise. These findings argue for the importance of inclusion of kidney disease among NCD targets for reducing premature death throughout the world.

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Section: Factors For Change: Population Burden Of Diabetes Mellitus Amentioning

confidence: 99%

Maintenance Dialysis throughout the World in Years 1990 and 2010

Thomas

Wulf

Bikbov

et al. 2015

Journal of the American Society of Nephrology

170

137

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“…[1] Diabetes mellitus is an increasing global public health concern. [2] A total of 382 million people had diabetes in 2013 and this number is expected to rise to 592 million by 2035. [3] Diabetes and breast cancer are quite prevalent chronic diseases among women.…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus and prognosis in women with breast cancer

Zhao

Ren

2016

Medicine

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Background:Diabetes mellitus is associated with an increased risk of breast cancer, but studies of the effects of diabetes on the prognosis of women with breast cancer have yielded inconsistent findings. The present meta-analysis aimed to investigate the impact of preexisting diabetes on the prognosis in terms of overall survival (OS), disease-free survival (DFS), and relapse-free period (RFP) in women with breast cancer.Methods:We searched the Embase and PubMed databases until June 2016 for cohort or case–control studies assessing the impact of diabetes on the prognosis of women with breast cancer. The pooled multivariate adjusted hazard ratio (HR) and their 95% confidence intervals (CIs) for OS, DFS, and RFP were used to analyze the impact of diabetes on the prognosis of breast cancer patients.Results:Seventeen studies involving 48,315 women with breast cancer met our predefined inclusion criteria. Meta-analysis showed that the pooled adjusted HR was 1.51 (95% CI 1.34–1.70) for OS and 1.28 (95% CI 1.09–1.50) for DFS in breast cancer patients with diabetes compared to those without diabetes. However, RFP did not differ significantly between patients with and without diabetes (HR 1.42; 95% CI 0.90–2.23).Conclusions:The present meta-analysis suggests that preexisting diabetes is independently associated with poor OS and DFS in female breast cancer patients. However, the impact of diabetes on RFP should be further verified. More prospective studies are warranted to investigate whether appropriate glycemic control with modification of antihyperglycemic agents can improve the prognosis of female breast cancer patients with diabetes.

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“…Diabetic complications are associated with mortality (9, 10) and disability (11). People with diabetes are vulnerable to the traditional microvascular and macrovascular complications of diabetes but are also at an increased risk for geriatric syndromes, such dementia (12). Mild cognitive impairment is associated with the presence of diabetic complications and other factors related to diabetic severity, such as earlier onset, longer duration, and treatment with insulin (13).…”

mentioning

confidence: 99%