Epidemiology of dengue in Argentina: Antibodies seroprevalence in blood donors and circulating serotypes

Flichman, Diego Martín; Pereson, Matías J.; Baré, Patricia; Espindola, Sonia L.; Carballo, Graciela Mabel; Albrecht, Andrés; Agote, Felicitas; Alter, Adriana; Bartoli, Sonia; Blanco, Sebastián; Blejer, Jorgelina L.; Borda, Marcelo; Bouzon, Néstor; Carrizo, Luis; Etcheverry, Lucrecia; Fernandez, Roberto; Reyes, Maria Ines; Gallego, Sandra; Hahn, Romina; Luna, Silvana Gisela; Marranzino, Gabriela; Romanazzi, Joaquín Suarez; Rossi, Ariel; Troffe, Antonia; Lin, Cheng Wen; Martínez, Alfredo P.; García, Gabriel; Lello, Federico A. Di

doi:10.1016/j.jcv.2022.105078

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…The observed seroprevalence (15.2%, 95% CI: 10.7-21.1) was similar to the estimates found in blood donors in the Central Region of Argentina which includes Santa Fe (12.9%) (Flichman et al 2022). However, it was lower than the seroprevalence of anti-DENV antibodies among adult individuals who reported no prior infection with dengue in Posadas (20.5%), a city located in northeastern Argentina [15].…”

Section: Discussionsupporting

confidence: 83%

Seropositivity to Dengue virus (DENV) in three neighborhoods in the periphery of a city with a recent history of outbreaks in Argentina: what can we learn from unreported cases?

Mendicino,

Ricardo,

Cristaldi

et al. 2024

Preprint

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BackgroundArgentina has experienced several dengue outbreaks since its reemergence in 1998, but cases are underreported due to asymptomatic infections and inadequate access to the healthcare system, particularly in marginalized neighborhoods.MethodsBetween December 2019 and March 2020, we assessed seroprevalence of DENV in three neighborhoods in the periphery of the city of Santa Fe. Serum samples were obtained from one adult per household and analyzed by ELISA for DENV IgG antibodies. Multivariate logistic regression models were used to analyze seropositivity by demographic, socio-economic and environmental variables.ResultsFrom 184 participants,overall seroprevalence was 15.2% (95% CI: 10.7; 21.1%). Proximity to a vacant lot decreased the likelihood of seropositivity by 65% (OR: 0.35; 95% CI: 0.15; 0.80). This aligns with studies suggesting vegetation cover can reduce vector abundance and that DENV transmission is higher in densely populated urban areas. Surprisingly, knowledge of disease symptoms and transmission was not linked to lower seropositivity, echoing findings from other studies.ConclusionsThese findings contribute to building consensus on the factors that increase DENV infection and will be valuable in designing public health interventions in vulnerable neighborhoods during dengue outbreaks.

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Section: Discussionsupporting

confidence: 83%

Seropositivity to Dengue virus (DENV) in three neighborhoods in the periphery of a city with a recent history of outbreaks in Argentina: what can we learn from unreported cases?

Mendicino,

Ricardo,

Cristaldi

et al. 2024

Preprint

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“…Although antibody prevalence against dengue in blood donors from Argentina has been recently published, these values do not reflect antibody cross‐reaction against related Flaviviruses 3 . This would explain the difference in prevalence values found in our study (2%–4.5%) compared to the 12.5% seroprevalence reported by Flichman et al 3 Dengue is among the most important mosquito‐borne viral diseases in the world 26 . The risk of transfusion transmission of this virus has already been discussed in several reports 27–30 .…”

Section: Discussionmentioning

confidence: 95%

“…The Flaviviruses Dengue (DENV), Zika (ZIKV) and Saint Louis Encephalitis (SLEV) (family Flaviviridae, genus flavivirus) and the Alphavirus Chikungunya (CHIKV) (family Togaviridae, genus alphavirus) are the most significant arboviruses in medical practice of Argentina, constituting a continuous threat for public health. While not homogeneously distributed in all regions of the country, the geographic spread of these mosquito‐borne viruses has progressively increased over time and endemic areas are currently extended 2,3 . The Argentinean government has implemented different measures attempting to control the spread of arbovirus infections mainly in times of outbreaks; however, the risk of transfusion‐transmitted infections (TTIs) has not been assessed yet.…”

Section: Introductionmentioning

confidence: 99%

“…While not homogeneously distributed in all regions of the country, the geographic spread of these mosquito-borne viruses has progressively increased over time and endemic areas are currently extended. 2,3 The Argentinean government has implemented different measures attempting to control the spread of arbovirus infections mainly in times of outbreaks; however, the risk of transfusion-transmitted infections (TTIs) has not been assessed yet.…”

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confidence: 99%

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Haemovigilance survey and screening strategy for arthropod‐borne viruses in blood donors from Argentina

Blanco,

Marín,

Frutos

et al. 2024

Journal of Medical Virology

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Arthropod‐borne viruses (arboviruses) count among emerging infections, which represent a major challenge for transfusion safety worldwide. To assess the risk of arboviruses‐transmission by transfusion (ATT), we performed a survey to evaluate the potential threat for transfusion safety. Samples were retrospectively and randomly collected from donors who donated during the peak of dengue incidence in Cordoba (years: 2016 and 2019–2022). A cost‐efficient strategy for molecular screening was implemented with a nucleic acid test (NAT) configured with Flavivirus and Alphavirus‐universal degenerated primers targeting conserved gene regions. Besides, we evaluated the neutralizing antibody (NAb) prevalence by plaque reduction neutralization test (PRNT). A total of 1438 samples were collected. Among the NAT‐screened samples, one resulted positive for Flavivirus detection. Subsequent sequencing of the PCR product revealed Saint Louis Encephalitis Virus (SLEV) infection (GeneBank accession number OR236721). NAb prevalence was 2.95% for anti‐Dengue, 9.94% anti‐SLEV, 1.09% anti‐West Nile Virus, and 0% anti‐Chikungunya. One of the NAb‐positive samples also resulted positive for IgM against SLEV but negative by ARN detection. This is the first haemovigilance study developed in Argentina that evaluates the potential risk of ATT and the first research to determine the prevalence of NAb against Flavivirus through PNRT to avoid possible cross‐reactions between Ab against Flavivirus. Herein, the finding of one SLEV‐viremic donor and the detection of anti‐SLEV IgM in a different donor demonstrated a potential threat for transfusion safety and emphasized the need for increased vigilance and proactive measures to ensure the safety of blood supplies.

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Seroprevalence of dengue IgG and associated risk factors in symptomatic and asymptomatic adults in Posadas (Misiones, Argentina), 2017-2019

Vogel,

Silva,

Otero-Rodríguez

et al. 2024

Journal of Infection and Public Health

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Epidemiology of dengue in Argentina: Antibodies seroprevalence in blood donors and circulating serotypes

Cited by 3 publications

References 41 publications

Seropositivity to Dengue virus (DENV) in three neighborhoods in the periphery of a city with a recent history of outbreaks in Argentina: what can we learn from unreported cases?

Seropositivity to Dengue virus (DENV) in three neighborhoods in the periphery of a city with a recent history of outbreaks in Argentina: what can we learn from unreported cases?

Haemovigilance survey and screening strategy for arthropod‐borne viruses in blood donors from Argentina

Seroprevalence of dengue IgG and associated risk factors in symptomatic and asymptomatic adults in Posadas (Misiones, Argentina), 2017-2019

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