Epidemiology of Cytomegalovirus Infections

Ho, Monto

doi:10.1093/clinids/12.supplement_7.s701

Cited by 322 publications

(174 citation statements)

References 56 publications

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“…Cytomegalovirus (CMV)infection is an opportunistic infection that primarily affects patients with acquired immunodeficiency syndrome (AIDS), transplant recipients and patients receiving immunosuppressive therapy (1). Although the primary CMVinfection in immunocompetentindividuals usually leads to acute hepatitis and/or mononucleosis syndrome (1), this infection in immunocompromisedhosts is serious and lifethreatening with substantial mortality (2).…”

Section: Introductionmentioning

confidence: 99%

“…Although the primary CMVinfection in immunocompetentindividuals usually leads to acute hepatitis and/or mononucleosis syndrome (1), this infection in immunocompromisedhosts is serious and lifethreatening with substantial mortality (2). Furthermore, this infection manifests itself in the lung, liver, central nervous systern, eyes, and gastrointestinal tract (2).…”

Section: Introductionmentioning

confidence: 99%

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Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.

et al. 2002

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Here, wereport a case of systemic lupus erythematosus (SLE) complicated by cytomegalovirus (CMV)-induced hemophagocytic syndrome (HPS) and colitis. A 44-year-old womanwith SLE was treated with corticosteroid and cyclophosphamide for lupus nephritis. Although her lupus nephritis improved, fever, progressive pancytopenia and intestinal bleeding were observed. A bone marrow aspiration showed an increase in mature histiocytes with hemophagocytosis. In addition, a colonoscopy showed hemorrhagic colitis with ulcer and the biopsy specimen from the colon revealed typical CMVcells with CMVinclusions confirmed by immunohistochemistry. Furthermore, a large number of CMVantigen-positive leukocytes was detected, suggesting an active CMVinfection. CMVinfection is serious in compromised hosts. Therefore clinicians should be aware of the clinical settings in which this infection can arise and the target organs potentially affected in order to initiate the appropriate intervention. (Internal Medicine 41: 151-155, 2002)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.

et al. 2002

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“…H uman cytomegalovirus (HCMV) is a member of the β-herpesvirus subfamily with >60% seropositivity in adults worldwide (1). HCMV infection is typically asymptomatic, but can cause severe disease or death in immunocompromised solid organ and hematopoietic stem cell transplant recipients.…”

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confidence: 99%

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes

Ciferri

Chandramouli

Donnarumma

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

138

189

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Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and the leading viral cause of birth defects after congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are key targets of the human humoral response against HCMV and are required for HCMV entry into fibroblasts and endothelial/epithelial cells, respectively. We expressed and characterized soluble forms of gH/gL, gH/gL/gO, and Pentamer. Mass spectrometry and mutagenesis analysis revealed that gL-Cys144 forms disulfide bonds with gO-Cys351 in gH/gL/gO and with UL128-Cys162 in the Pentamer. Notably, Pentamer harboring the UL128-Cys162Ser/gL-Cys144Ser mutations had impaired syncytia formation and reduced interference of HCMV entry into epithelial cells. Electron microscopy analysis showed that HCMV gH/gL resembles HSV gH/gL and that gO and UL128/UL130/UL131A bind to the same site at the gH/gL N terminus. These data are consistent with gH/gL/gO and Pentamer forming mutually exclusive cell entry complexes and reveal the overall location of gH/gL-, gH/gL/ gO-, and Pentamer-specific neutralizing antibody binding sites. Our results provide, to our knowledge, the first structural view of gH/gL/ gO and Pentamer supporting the development of vaccines and antibody therapeutics against HCMV.human cytomegalovirus | HCMV | Pentamer complex | gH/gL/gO | virus entry

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“…The incidence of infection in seropositive patients with allogeneic HSCT is between 42% and 69%, and of clinical disease, between 16% and 25% [21,22]. This incidence of infection and disease is much higher in allogeneic than in autologous recipients: 21-38% versus 0-4%, respectively [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

The Mexican schedule to conduct allogeneic stem cell transplantation is related to a low risk of cytomegalovirus reactivation and disease

et al. 2004

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The prevalence of cytomegalovirus (CMV) reactivation and disease after non-myeloablative stem cell transplantation is largely unknown. Using fludarabine combined with alemtuzumab or antithymocyte globulin in the conditioning regimen, some authors have found increased prevalences of CMV disease, whereas other authors using different schedules have observed decreased prevalences. In a group of 17 individuals allografted using the Mexican conditioning regimen, which employs fludarabine, cyclophosphamide, and busulfan, we assessed CMV reactivation, morbidity, and mortality. Before transplant, IgG anti-CMV antibodies were found in 11 patients and in 10 donors; in 8 cases, both donor and patient had IgG anti-CMV antibodies. In only one case (6%) was CMV mRNA identified 30 days after the allograft during grade IV acute graft-versus-host disease. CMV reactivation, disease, and mortality were very low using our non-myeloablative stem cell transplantation schedule, which has been shown to be useful for allografting with minimal toxicity and reduced costs. Am.

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Epidemiology of Cytomegalovirus Infections

Cited by 322 publications

References 56 publications

Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.

Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.

Structural and biochemical studies of HCMV gH/gL/gO and Pentamer reveal mutually exclusive cell entry complexes

The Mexican schedule to conduct allogeneic stem cell transplantation is related to a low risk of cytomegalovirus reactivation and disease

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