Epidemiology of concurrent Chagas disease and ischemic stroke in a population attending a multicenter quaternary rehabilitation network in Brazil

Montanaro, Vinícius Viana Abreu; Hora, Thiago Falcão; Silva, Creuza Maria da; Santos, Carla Verônica de Viana; Lima, Maria Inacia Ruas; Oliveira, Eleonora Maria de Jesus; Freitas, Gabriel R. de

doi:10.1007/s10072-019-04018-8

Cited by 7 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 In addition, future studies about access to rehabilitation in particular subgroups of patients with stroke (for instance, with other diseases that can lead to heart disease, such as Chagas disease and coronary heart disease) are needed. 37,38 In summary, AReA will provide a snapshot of rehabilitation services in Brazil and most of the data will be collected during the COVID-19 pandemic. The results of the present study will be key to develop public health strategies and to guide efforts to provide novel rehabilitation options in a challenging context, to change the game against disability from stroke.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Access to rehabilitation after stroke in Brazil (AReA study): multicenter study protocol

et al. 2022

View full text Add to dashboard Cite

Background Most of the Brazilian population relies on public healthcare and stroke is a major cause of disability in this country of continental dimensions. There is limited information about access to rehabilitation after stroke in Brazil. Objective To provide comprehensive information about Access to Rehabilitation After discharge from public hospitals in Brazil (AReA study), up to 6 months after stroke. Methods The present study intends to collect information from 17 public health centers in 16 Brazilian cities in the 5 macroregions of the country. Each center will include 36 participants (n = 612). The inclusion criteria are: age ≥ 18 years old; ischemic or hemorrhagic stroke, from 6 months to 1 year prior to the interview; admission to a public hospital in the acute phase after stroke; any neurological impairment poststroke; patient or caregiver able to provide informed consent and answer the survey. Patients can only be recruited in public neurology or internal medicine outpatient clinics. Outcomes will be assessed by a standard questionnaire about rehabilitation referrals, the rehabilitation program (current status, duration in months, number of sessions per week) and instructions received. In addition, patients will be asked about preferences for locations of rehabilitation (hospitals, clinics, or at home). Trial Status The study is ongoing. Recruitment started on January 31st, 2020 and is planned to continue until June 2022. Conclusion The AReA study will fill a gap in knowledge about access to stroke rehabilitation in the public health system in different Brazilian regions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Access to rehabilitation after stroke in Brazil (AReA study): multicenter study protocol

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As circadian rhythm disturbances are commonly reported post-TBI, another intriguing prospect for interplay between African trypanosomes and TBI would be in regard to circadian rhythm alterations given that African trypanosomes are notoriously known to reverse sleep cycles [282,285]. Chagas disease, which is also known as American trypanosomiasis, is common in Latin American stroke patients and can present with highly varied neurological manifestations [286,287]. However, as cardiac and digestive tissues are predominantly infected, with cardiomyopathy being the main clinical feature in the chronic stage, neuroinflammatory events have not been well characterized for this disease and the capacity to speculate about a potential overlap with TBI pathophysiology is limited [288].…”

Section: Future Directionsmentioning

confidence: 99%

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Baker

Sun

Semple

et al. 2020

J Neuroinflammation

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is hindered by the heterogenous nature of TBI presentation and pathophysiology. In particular, the degree of neuroinflammation after TBI varies between individuals and may be modified by other factors such as infection. Toxoplasma gondii, a parasite that infects approximately one-third of the world's population, has a tropism for brain tissue and can persist as a lifelong infection. Importantly, there is notable overlap in the pathophysiology between TBI and T. gondii infection, including neuroinflammation. This paper will review current understandings of the clinical problems, pathophysiological mechanisms, and functional outcomes of TBI and T. gondii, before considering the potential synergy between the two conditions. In particular, the discussion will focus on neuroinflammatory processes such as microglial activation, inflammatory cytokines, and peripheral immune cell recruitment that occur during T. gondii infection and after TBI. We will present the notion that these overlapping pathologies in TBI individuals with a chronic T. gondii infection have the strong potential to exacerbate neuroinflammation and related brain damage, leading to amplified functional deficits. The impact of chronic T. gondii infection on TBI should therefore be investigated in both preclinical and clinical studies as the possible interplay could influence treatment strategies.

show abstract

“…In addition to mortality, health service costs increase, and quality of life (QoL) is compromised [8][9][10] . In addition to the economic cost and impairment of QoL, ChD mainly affects vulnerable people and communities with limited access to health services, limited educational opportunities, and low income [10][11][12][13][14] . Thus, it is of great importance that health policies act on the social determinants of health to contain the social costs of ChD 15 .…”

Section: Introductionmentioning

confidence: 99%

Chagas disease and perceived quality of life: a cross-sectional study

Baldoni,

Quintino,

Oliveira

et al. 2023

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Background: Chagas disease (ChD) is a neglected tropical disease that is caused by the protozoan parasite Trypanosoma cruzi and can negatively impact quality of life (QoL). This study aimed to assess and compare QoL between individuals with and without ChD. Methods: This cross-sectional study was performed within a concurrent cohort study (REDS). The participants were derived from two blood donation centers: São Paulo capital and Montes Claros, Minas Gerais, Brazil. Participants with ChD were identified in blood donations by serological diagnosis between 2008 and 2010, and those without ChD were donors with negative serology identified during the same period. QoL was assessed using the World Health Organization Quality of Life-BREF questionnaire. Logistic regression was used to compare sociodemographic and clinical characteristics between the groups, and mean, standard deviation, and beta regression were used to compare QoL. Results: In total, 611 individuals participated in the study (328 with ChD and 283 without ChD). Participants with ChD had lower QoL in the physical (p=0.02) and psychological (p<0.01) domains than did individuals without CD. Conclusions: Individuals with ChD had worse QoL perceptions. These results provide a comprehensive understanding of the impact of ChD on individuals' QoL, while also highlighting potential opportunities for improving the care and treatment of those affected.

show abstract

Epidemiology of concurrent Chagas disease and ischemic stroke in a population attending a multicenter quaternary rehabilitation network in Brazil

Cited by 7 publications

References 20 publications

Access to rehabilitation after stroke in Brazil (AReA study): multicenter study protocol

Access to rehabilitation after stroke in Brazil (AReA study): multicenter study protocol

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Chagas disease and perceived quality of life: a cross-sectional study

Contact Info

Product

Resources

About