Epidemiology of colorectal polyps

Abstract

The prevalence of colorectal adenomatous polyps varies widely from country to country. Among asymptomatic, average-risk patients, adenoma prevalence averages approximately 10% in sigmoidoscopy studies and more than 25% in colonoscopy studies, whereas the prevalence of colorectal cancer among these patients is less than 1%. These data may change in the future due to the advent of new technological approaches and, in particular, chromo- and magnifying endoscopy as well as confocal laser endoscopy. The cumulative incidence of new adenomas within 3 years after normal endoscopy averages about 7% by flexible sigmoidoscopy and 27% by colonoscopy. As far as risk factors for colorectal adenomas are concerned, several data are now available on the potential role of various diet items. Tobacco smoking may be important in the early stages of adenoma formation, but not necessarily in the later stages. Alcohol consumption elevates the risk of adenomatous colorectal polyps and this seems increased by ADH3 polymorphism. Another gene-environment relationship of interest in colorectal tumorigenesis may be based on folate's effects on K-ras mutations.

Demographic And Histopathological Characteristics Of Colorectal Polyps: A Descriptive Study Based On Samples Obtained From Symptomatic Patients

“…A direct comparison of our findings with previous studies is challenging due to differences with regard to study period and population (in terms of age, gender and ethnicity). In addition, it has been shown that the prevalence of adenomas based on autopsy studies is higher than that reported from studies based on endoscopy findings (12). Unauthenticated Download Date | 5/12/18 11:55 AM provide additional valid evidence.…”

Moderate Alcohol Consumption Protects Against Colorectal Adenomas in Smokers

“…There is some suggestion for the role of folate (24,28,29). Additionally, both smoking and alcohol have been associated with expression of the tumor suppressor gene p53.…”

Análise dos pólipos colorretais em 3.491 videocolonoscopias

“…Caso não sejam encontrados novos pólipos, esse tempo estende-se para 5 anos. Em caso de presença de adenocarcinoma, fazse necessário um seguimento mais rigoroso em 6 meses, 2 e 5 anos, dependendo do nível de invasão do mesmo 14,15,16 . O objetivo do presente estudo é analisar a incidência dos pólipos, seu tipo histológico e o índice de malignização nos pacientes submetidos a exame videocolonoscópico por indicações diversas, bem como a necessidade de exames endoscópicos de controle nesses pacientes.…”