Epidemiology of clinical isolates of Candida albicans and their susceptibility to triazoles

Wróblewska, Marta; Swoboda-Kopeć, Ewa; Rokosz, A; Krawczyk, Ewa; Marchel, Halina; Łuczak, M.

doi:10.1016/s0924-8579(02)00246-7

Cited by 25 publications

(13 citation statements)

References 21 publications

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“…The resistance against various drugs used against Candida spp. is variable around the globe, yet it is increasing especially against azoles that serve as main drugs used for the candidiasis (Wroblewska et al, 2002). In the present study, anticandidal activity was seen in all of the test fractions with the exception of aqueous fraction, with highest activity seen in the QDM fraction.…”

Section: Discussionsupporting

confidence: 48%

Evaluation of anticandidal potential of Quercus baloot Griff. using contact bioautography technique

Khurram¹

2011

Afr. J. Pharm. Pharmacol.

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The activities of fractions derived from hydroalcoholic extract of Quercus baloot leaves against a dimorphoic pathogenic yeast, Candida albicans (Cl. I. 4043) was evaluated. The hydroalcoholic extract was sequentially fractionated to give n-hexane, dichloromethane, ethylacetate, and n-butanol fractions, which were also subjected to qualitative phytochemical analyses. Preliminary anticandidal screening was carried out using disk diffusion assay with clotrimazole and chloroform serving as positive and negative controls, respectively. Using optimized solvent systems for each fraction, thin layer chromatography was done to separate the secondary metabolites that were evaluated for bioactivity using contact bioautography technique. Minimum inhibitory concentrations of the individual fractions were found using broth microdilution method. Preliminary screening showed all the fractions, apart from aqueous fraction, to have anticandidal potential (zone of inhibition 10 mm) against test yeast. However, contact bioautography revealed that only dichloromethane fraction was bioactive with inhibition zones at R f = 0.44 and 0.50, which showed location of inhibitory compound. The MIC of 125 µg/ml also support the presence of anticandidal moieties in this fraction. Phytochemical analyses indicated flavonoids, terpenoids, and steroids in the fractions.

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Section: Discussionsupporting

confidence: 48%

Evaluation of anticandidal potential of Quercus baloot Griff. using contact bioautography technique

Khurram¹

2011

Afr. J. Pharm. Pharmacol.

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“…In fact, the most common diseases that predispose to an increased sensitivity to C. albicans overgrowth are diabetes mellitus, cancer, leukemia, AIDS, thyroid dysfunction and other diseases, in which host defense mechanisms are suppressed or adrenal cortex steroids/antibiotics/other similar drugs are used (immunosuppressed patients) [6,10,12,24,25,37,40,53,56,[70][71][72].…”

Section: Impaired Immune System and Underlying Disease Statesmentioning

confidence: 99%

“…Since deep infections have been increasing, mainly in hospitals, the following aspects should be considered: probes and catheters should be regularly monitored and removed, as soon as possible; and the frequency, duration and amplitude of the quantities of antibiotics should be kept to a minimum [3,6,9,14,49,72,90].…”

Section: Preventionmentioning

confidence: 99%

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

et al. 2014

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SUMMARYCandidiasis is the most common opportunistic yeast infection. Candida species and other microorganisms are involved in this complicated fungal infection, but Candida albicans continues to be the most prevalent. In the past two decades, it has been observed an abnormal overgrowth in the gastrointestinal, urinary and respiratory tracts, not only in immunocompromised patients, but also related to nosocomial infections and even in healthy individuals. There is a widely variety of causal factors that contribute to yeast infection which means that candidiasis is a good example of a multifactorial syndrome. Due to rapid increase in the incidence of these infections, this is the subject of numerous studies. Recently, the focus of attention is the treatment and, above all, the prevention of those complications. The diagnosis of candidiasis could become quite complicated. Prevention is the most effective "treatment", much more than eradication of the yeast with antifungal agents. There are several aspects to consider in the daily routine that can provide a strength protection. However, a therapeutic approach is necessary when the infection is established and, therefore, other alternatives should be explored. This review provides an overview on predisposition factors, prevention and diagnosis of candidiasis, highlighting alternative approaches for candidiasis treatment.

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“…Antifungal resistance to fluconazole (FCZ), itraconazole (ITZ), and ketoconazole (KTZ) has been described and particularly in the setting of oral candidiasis in HIV/AIDS patients (6,14,15,25,26). Cross-sectional surveys have indicated a prevalence of FCZ-resistant oral C. albicans isolates of 12 to 19% (20).…”

mentioning

confidence: 99%

OralCandidaIsolates Colonizing or Infecting Human Immunodeficiency Virus-Infected and Healthy Persons in Mexico

et al. 2005

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Oral yeast carriage was studied in 312 Mexican subjects. Candida albicans was the most frequent species, but other Candida spp. were isolated from 16.5 to 38.5% of patients. Colonization did not correlate with CD4 ؉ number or viral load, but highly active antiretroviral therapy reduced the frequency of candidiasis. Most isolates were susceptible to fluconazole, but 10.8% were resistant to one or more azoles.

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Epidemiology of clinical isolates of Candida albicans and their susceptibility to triazoles

Cited by 25 publications

References 21 publications

Evaluation of anticandidal potential of Quercus baloot Griff. using contact bioautography technique

Evaluation of anticandidal potential of Quercus baloot Griff. using contact bioautography technique

Candidiasis: Predisposing Factors, Prevention, Diagnosis and Alternative Treatment

OralCandidaIsolates Colonizing or Infecting Human Immunodeficiency Virus-Infected and Healthy Persons in Mexico

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