Epidemiology of Chronic Venous Disease Among Rural Residents of Tajikistan

SULTANOV, D.D.; Калмыков, Е.Л.; Gaibov, A. D.; Soliev, O. F.; Dodkhoev, Dzh. S.; Nematzoda, O.

doi:10.17116/flebo201913041307

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Some studied regions were located on the border between the areas with high and low gravity fields. [35][36][37] To correctly obtain the mGal variable in those studies, we additionally assessed geographical characteristics and mass distribution in the geophysical area.…”

Section: Limitationsmentioning

confidence: 99%

Earth’s gravity field and prevalence of varicose veins and chronic venous disease: Systematic review

Rusinovich

2022

Phlebology

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Aim This study examines the influence of Earth’s gravity field on the prevalence of varicose veins in geophysical area. Material and Methods We performed a systematic review (OVID and Google Scholar) of studies focusing on prevalence of varicose veins to determine the influence of Earth’s gravity field—GRACE GGM05S gravity model—on the disease prevalence. PROSPERO: CRD42021279513. Results 81 studies met inclusion and quality criteria. Areas with stronger gravity have significantly higher prevalence of varicose veins with adjustment for age, gender and body mass index (BMI) ( p-values < 0.02). Adjusted for age, prevalence of varicose veins in areas with gravity field +20 mGal and more is 1.37 time higher than in areas with gravity field less than +20 mGal, p-value 0.005 (95% CI: −12.5 to −2.4): mean disease prevalence for gravity field +20 mGal and more—27.5% (mean age, 40.1 years; mean gravity field, +27.1 mGal; 63.9% females, 37 studies, 123,164 participants) vs mean disease prevalence for gravity field less than +20 mGal – 20.1% (mean age, 42.2 years; mean gravity field, +5.7 mGal; 56.8% females, 44 studies, 205,925 participants). Older age is the main risk factor for varicose veins ( p-values < 0.005). Female gender and high BMI are insignificantly associated with high prevalence of varicose veins ( p-values > 0.4 for gender, p-values > 0.2 for BMI). Conclusion Stronger gravity field is significantly associated with higher prevalence of varicose veins—risk factor. The potential mechanism of this phenomenon is that high gravity field alters systemic venous return, pooling blood and fluid in the peripheral, gravity-dependent regions of the body in upright humans constantly living in the defined geophysical area.

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Section: Limitationsmentioning

confidence: 99%

Earth’s gravity field and prevalence of varicose veins and chronic venous disease: Systematic review

Rusinovich

2022

Phlebology

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“…Анализ данных литературы показывает, что варикозная болезнь (ВБ) продолжает оставаться самой распространённой патологией сосудистой системы и в течение жизни развиваются у 20,3-81,4% взрослого населения, гораздо чаще всего среди лиц женского пола [11,17,21]. Проведённое ранее нами исследование показало, что различной степенью тяжести ВБ страдают 47,6% взрослого населения нашего региона (на примере двух пилотных районов), 19,2% из которых нуждаются в оперативном лечении [3,6]. Такая высокая частота распространённости ВБ особенно среди лиц молодого активного трудового возраста диктует поиска путей, направленных на её профилактику, и предупреждения значимых осложнений [3].…”

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Results of mechano-chemical obliteration of the trunk of the great saphenous vein in varicose vein disease

Nejmatzoda,

Gaibov,

Sultanov

et al. 2024

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Aim: To evaluate the effectiveness of mechano-chemical obliteration in the treatment of varicose enlargement of the great saphenous vein.Material and Methods: The results of mechano-chemical obliteration of 57 patients (49 (85.9%) women, 8 (14.1%) men; average age 27.2±4.1 years) with varicose disease were analyzed. In 39 patients (36 women and 3 men), the second, and in 18 (13 women and 5 men) – the third class of varicose transformation of subcutaneous veins was observed. The average body mass index of patients was 28.2±2.4 kg/m2, and the average duration of varicose disease was 7.6±1.8 years.Results and Discussion: The average diameter of the great saphenous vein was 10.4±2.1 mm. Insufficiency of perforating veins with an average diameter of 3.2±0.8 mm was detected in 31 (54.4%) cases. The technical success of the procedure was 100%. No intraoperative complications occurred in any patient. The average duration of mechanochemical obliteration was 24.2±4.8 minutes, and the entire operation – crossectomy, mechano-chemical obliteration, and excision of dilated tributary veins – lasted 98.5±25.5 minutes. The average length of the great saphenous vein subjected to mechano-chemical obliteration was 94.2±6.1 cm. The level of pain on the first day after surgery was 3.8±0.6 points, decreasing to 0.9±0.1 points before discharge. Only on the day after the intervention, patients required narcotic analgesics (average volume of used anesthetics – 1.5±0.5 ml); on other days, patients received non-steroidal anti-inflammatory drugs (average duration 3.5±0.5 days, volume – 10.5±1.5 ml).Conclusion: Mechano-chemical scleroobliteration is one of the effective methods for eliminating pathological vertical reflux, with its effectiveness observed in the vast majority of patients in the long term.Moreover, due to its minimal invasiveness and capability for repeated application, it can be recommended for widespread clinical use. To improve the results of mechano-chemical obliteration and reduce the frequency of recanalization of the great saphenous vein, it is necessary to supplement the procedure with crossectomy and miniphlebectomy.

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“…Варикозная болезнь (ВБ) продолжает оставаться самой распространенной патологией венозной системы и выявляется у 21,1%-80,4% населения различных регионов мира [3,14]. В Таджикистане различные формы этой патологии была выявлена у 47,8% среди общего населения, в основном лиц женского пола молодого и среднего возрастов [2,5].…”

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“…Согласно данным большинства проведенных исследований наиболее распространенной формой ВБ является телеангиоэктазии и ретикулярная форма расширения подкожных вен, которые не проявляются значимыми клиническими признаками кроме косметического дефекта конечности [5,14,16]. Вместе с тем, при несвоевременном лечении указанных форм ВБ происходит не только усугубление течения процесса, но и часто, при незначительных ударах и ушибах, происходит их разрыв с масштабными внутрикожными кровоизлияниями, после которого нередко развивается стойкая гиперпигментация кожи оказывающее значимое влияние на качество жизни пациентов [14].…”

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“…С целью профилактики подобного осложнения нами в последующем Обсуждение. В настоящее время из-за роста ВБ среди населения её профилактика, ранняя диагностика и лечение являются приоритетными в сосудистой хирургии [3,5,14]. По современным представлениям основными принципами лечения ВБ включает в себя не только устранения варикозного синдрома, но и устранение и предупреждение прогрессирования признаков хронической венозной недостаточности и профилактику прогрессирования и рецидивов заболевания [3,14].…”

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The place of sclerotherapy in the treatment of varicose vein disease

Nematzoda¹,

Султанов

Gaibov

et al. 2023

jour

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Aim. To evaluate effectiveness of the scleroobliteration in the treatment of small-diameter varicose veins.Materials and Methods. The analysis incorporated the results of sclerotherapy in 135 patients, comprising those with telangiectasias and reticular varicose veins (n=95) and those with varicose dilation of aberrant subcutaneous veins (n=40) with intact trunks of major and/or minor subcutaneous veins of the lower extremities. The sample included 111 women (82.2%) and 24 men (17.8%), with an average age of 35.2±6.5 years.For the obliteration of expanded subcutaneous veins, two sclerotherapy techniques were employed: liquid (n=65) and foam-form (n=70), prepared as per the L. Tessari method. Sclerosants used were a 0.5–3% sodium tetradecyl sulfate solution (“Fibro vein”) (ATC code: C05BB04) (n=69) or a 1-3% polidocanol solution (“Ethoxisclerol”) (ATC code: C05BB02) (n=66).A detailed analysis was carried out of all complications that developed during and at various times post-sclerotherapy, and the effectiveness of the treatment, which depended on the diameter of the expanded veins and the thoroughness of the procedure.Results. The technical success of the procedure was registered at 100%. The overall frequency of complications post-sclerotherapy was 20.7%, including 27.7% with the liquid form and 14.3% with the foam form of sclerosants (p<0.001). Intradermal and subcutaneous hemorrhages were observed in 10 (7.4%) patients, allergic reactions in 8 (5.9%), localized skin necrosis in 3 (2.2%), folliculitis in 3 (2.2%), and localized purulent complications in 2 (1.5%). Micro-air embolism of the pulmonary artery branches due to exceeding the established norm of air volume during foam sclerotherapy was recorded in 2 (2.9%) cases.Following one session, a positive sclerotherapy effect was noted in 45.9% of patients. The necessity for additional sclerotherapy courses was indicated for over half the patients, with the effectiveness rising to 97.8% after 3 or more courses.Conclusion. Sclerotherapy, being an effective minimally invasive method, is significantly impactful in treating reticular varices and telangiectasias. Greater efficiency and a lower rate of complications have been observed with the use of foam form sclerosant. Proper selection of sclerosant volume and concentration is essential for the prevention and reduction of sclerotherapy complications.

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Epidemiology of Chronic Venous Disease Among Rural Residents of Tajikistan

Cited by 10 publications

References 20 publications

Earth’s gravity field and prevalence of varicose veins and chronic venous disease: Systematic review

Earth’s gravity field and prevalence of varicose veins and chronic venous disease: Systematic review

Results of mechano-chemical obliteration of the trunk of the great saphenous vein in varicose vein disease

The place of sclerotherapy in the treatment of varicose vein disease

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