Epidemiology of Chronic Kidney Disease

McClellan, William M.; Port, Friedrich K.

doi:10.1002/9781444303391.ch1

Cited by 2 publications

(2 citation statements)

References 65 publications

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“…Present study population of 330 patients comprised adults, mainly illiterate (54.5%), and coming from rural-strata(66.4%) with a mean age of 52.67±15.05 (range 25 to 98 years), of whom mostly patients were taking vegetarian diet (58.2%).The mean age of our study population was similar to other studies like a mean age of 49.3 years with range 17-80 13 and a mean age of 46.6±13.4 years 14 . However, higher mean age was reported in other Western and Indian studies [15][16][17] .In the present study it was observed that alterations in biochemical profile were common in CKD patients. 55.8% of patients for corrected serum calcium and 63.0% of patients for phosphorus were out of the target range.…”

Section: Figure 6: Relationship Between Corrected Calcium With Phosphorus Among Casescontrasting

confidence: 52%

Effect of Dietary Factors and Nutritional Status on Serum Calcium and Phosphorus Levels in CKD Patients on Treatment in a Tertiary Care Setting in North India

et al. 2020

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The control of phosphorus and calcium metabolism is one of the objectives in treatment protocol for CKD patients. The levels of these minerals in serum are affected by dietary patterns and nutritional status of the patients. India being a large country, diet patterns vary from one state to another. Thus, we suspect a close association between dietary intake and alterations in homeostasis of calcium and phosphorus in CKD patients. Therefore, we conduct this study to describe the effect of dietary factors and nutritional status on serum calcium and phosphorus levels in CKD patients on treatment in a tertiary care setting in North India. In the present study 330 CKD patients coming to dialysis unit, were recorded with detailed Medical history as well as baseline demographic data. Also, biochemical analysis of serum albumin corrected, calcium, phosphorus, and serum albumin of all cases were done using fully automated equipment. All statistical analyses were performed using SPSS statistical software, version 17. Majority (58.2 %) of the study patients were vegetarians with a mean value of BMI (Mean ± SD = 23.75 ± 4.70 kg/m2). A negative but significant correlation was found between corrected calcium and phosphorus with 0.05 level of confidence interval (r=-0.149, p= 0.007). It was found that the well-nourished patients were more likely to be hyperphosphatemic as compared to poorly nourished patients, but statistically the values were found to be non significant (Statistically p-value was not less than 0.05). Peer Review History: UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.5/10 Reviewer(s) detail: Name: Dina Abd Elfattah Eldakhs Affiliation: Pharos university (PUA), Egypt E-mail: dina_eldakhs@yahoo.com Name: Dr. Mohammad Tauseef Affiliation: Department of Pharmaceutical Sciences College of Pharmacy, Chicago State University E-mail: mtauseef@csu.edu Comments of reviewer(s): Similar Articles: NEW ERA OF MEDICINE: ROLE OF NUTRACEUTICALS IN TREATMENT AND PREVENTION OF VARIOUS DISEASES

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Section: Figure 6: Relationship Between Corrected Calcium With Phosphorus Among Casescontrasting

confidence: 52%

Effect of Dietary Factors and Nutritional Status on Serum Calcium and Phosphorus Levels in CKD Patients on Treatment in a Tertiary Care Setting in North India

et al. 2020

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“…[14–18] However, higher mean age was reported in an Western and an Indian study. [1920] We observed that males outnumbered females in both the groups (M:F 2.25:1 and 3.63:1 in groups I and II, respectively). There is male predominance among CKD population in most studies.…”

Section: Discussionmentioning

confidence: 77%

The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study

et al. 2012

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Mineral bone disorder (MBD) is an important complication of chronic kidney disease (CKD). However, there are limited data on the pattern of MBD in Indian CKD population. The aim of this study was to describe spectrum of MBD in patients with CKD in our center. This was a hospital-based cross-sectional observational study. Patients with stage 4 and 5 CKD were included in this study. Those receiving calcium supplement, vitamin D or its analogues, and calcimimetic were excluded. Serum/plasma levels of creatinine, albumin, calcium, phosphate, total alkaline phosphatase (TAP), intact parathormone (iPTH), and 25-OH vitaminD (25-vitD) were measured. Radiological survey of bones was carried out in all cases, and echocardiography done in selected patients. Statistical analysis was done using Sigmaplot 10.0 software. A total of 150 patients (114 males, 36 females) were included in this study. Mean age was 45.67±16.96 years. CKD stage 4 and 5D were found in 26% (n=39) and 74% (n=111) of study population, respectively. The most common underlying native kidney diseases in patients of CKD 4 and 5D were diabetic nephropathy (41.03%) and CGN (41.44%), respectively. Median (first quartile, third quartile) values for serum levels of corrected calcium (cCa), phosphate, cCaXPO4 product, TAP, plasma iPTH, and 25-vitD in stage 4 CKD were 8.36 (7.79, 8.91) mg/dL, 4.9 (3.92, 6.4) mg/dL, 41.11 (34.01, 53.81) mg2/dL2, 97 (76.5, 184.25) IU/L, 231 (124.5, 430.75) pg/mL, and 12 (6.98, 23.55) ng/mL, respectively; and in stage 5D CKD were 8.36 (7.66, 8.95) mg/dL, 5.7 (4.23, 6.95) mg/dL, 46.5 (37.16, 54.47) mg2/dL2, 180 (114.5, 276.25) IU/L, 288 (169.75, 625.0) pg/mL, and 18.4 (10.0, 26.4) ng/mL, respectively. Prevalence of hypocalcemia (56.41% vs. 54.95%), hyperphosphatemia (64.10% vs. 70.27%), and hyperparathyroidism (84.62% vs. 88.29%) was not different between patients with CKD 4 and 5D. However, iPTH level outside the target range and increased TAP level were significantly (P<0.001) more common in CKD stage 5D. Multiple logistic regression analysis for hyperparathyroidism revealed significant inverse correlation with cCa in CKD 5D. There were no significant differences in vitamin D status and prevalence of valvular calcification between CKD stage 4 and 5D. X-ray revealed renal osteodystrophy in 8 (5.33%) patients, while it was normal in 118 (78.67%) patients. Secondary hyperparathyroidism, hyperphosphatemia, hypocalcemia, increased TAP, and 25-OH vitamin D deficiency and insufficiency were quite common in CKD 4 and 5 patients. The commonest type of MBD in CKD 4 and 5D was secondary hyperparathyroidism.

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Epidemiology of Chronic Kidney Disease

Cited by 2 publications

References 65 publications

Effect of Dietary Factors and Nutritional Status on Serum Calcium and Phosphorus Levels in CKD Patients on Treatment in a Tertiary Care Setting in North India

Effect of Dietary Factors and Nutritional Status on Serum Calcium and Phosphorus Levels in CKD Patients on Treatment in a Tertiary Care Setting in North India

The high prevalence of chronic kidney disease-mineral bone disorders: A hospital-based cross-sectional study

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