The last decade has seen the emergence of two new infl uenza A subtypes and they have become a cause of concern for the global community. These are the highly pathogenic H5N1 infl uenza A virus (H5N1) and the Pandemic 2009 infl uenza H1N1 virus. Since 2003 the H5N1 virus has caused widespread disease and death in poultry, mainly in south East Asia and Africa. In humans the number of cases infected with this virus is few but the mortality has been about 60%. Most patients have presented with severe pneumonia and acute respiratory distress syndrome. The second infl uenza virus, the pandemic H1N1 2009, emerged in Mexico in March this year. This virus acquired the ability for sustained human to human spread and within a few months spread throughout the world and infected over 4 lakh individuals. The symptoms of infection with this virus are similar to seasonal infl uenza but it currently affecting younger individuals more often. Fortunately the mortality has been low. Both these new infl uenza viruses are currently circulating and have different clinical and epidemiological characteristics.