Epidemiology of canine visceral leishmaniosis in the endemic area of Montes Claros Municipality, Minas Gerais State, Brazil

França-Silva, João Carlos; Costa, Rosane Dias; Siqueira, Ari M.; Machado-Coelho, George Luis Lins; Costa, Carlos Alberto da; Mayrink, Wilson; Vieira, Edvá P.; Costa, Jaime S.; Genaro, Odair; Nascimento, Evaldo

doi:10.1016/s0304-4017(02)00351-5

Cited by 147 publications

(128 citation statements)

References 16 publications

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“…França-Silva et al 14 realizaram um inquérito sorológico no município de Montes Claros, no ano de 1997, onde foram avaliados 33.937 cães da área urbana e rural, e verificaram que a taxa média de prevalência da LVC foi de 9,7%. Seus estudos revelaram a importância do cão como reservatório para L. chagasi no município 14 .…”

Section: Resultsunclassified

Leishmaniose visceral: estudo de flebotomíneos e infecção canina em Montes Claros, Minas Gerais

Monteiro

Silva

Costa

et al. 2005

Rev. Soc. Bras. Med. Trop.

108

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RESUMO A leishmaniose visceral no Brasil estava inicialmente associada a áreas rurais, mas devido às diversas alterações no ambiente como, desmatamentos, urbanização e intenso processo migratório, ocorreu a expansão das áreas endêmicas, levando à urbanização da doença, principalmente nas regiõesAs leishmanioses são doenças enzoóticas e zoonóticas causadas por protozoários parasitas, morfologicamente similares, do gênero Leishmania (Kinetoplastida: Trypanosomatidae), podendo acometer o homem 6 .A leishmaniose visceral (LV) vem se tornando um importante problema de Saúde Pública, devido à sua incidência e alta letalidade, não só nas Américas mas na Europa, África, Ásia e Oriente Médio 17 . Nas Américas, a LV ocorre desde o México até a Argentina, sendo que cerca de 90% dos casos humanos descritos são procedentes do Brasil 16 . A LV apresenta amplo espectro epidemiológico no mundo, ocorrendo em vastas áreas tropicais e subtropicais do globo, podendo apresentar-se como zoonose, antroponose ou antropozoonose, estas duas últimas, quando o homem atua como reservatório no ciclo de transmissão do parasito 21 .

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Section: Resultsunclassified

Leishmaniose visceral: estudo de flebotomíneos e infecção canina em Montes Claros, Minas Gerais

Monteiro

Silva

Costa

et al. 2005

Rev. Soc. Bras. Med. Trop.

108

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“…Polymorphisms in the Slc11a1 gene have been associated with CVL in a case-control study with 97 dogs of different breeds [23]: three single nucleotide polymorphisms (SNP) in the Slc11a1 promoter region (T151C, A180G, G318A) were associated with increased risk for CVL in different breeds, and one haplotype was significantly associated with the Boxer breed, which may suggest varied predispositions to infectious disease among canine breeds. In fact, genetic epidemiologic surveys in dogs revealed higher prevalence of Leishmania infection (up to 25%) in Boxers, German Shepherds, Doberman Pinschers, Cocker Spaniels, and among American and English Foxhounds (held in foxpacks in North America) [8,11,12,23]. Conversely, certain canine breeds may be resistant to Leishmania infection and CVL such as the Mediterranean Ibizan Hound, an autochthonous breed from the Balearic Island of Ibiza [28].…”

Section: Introductionmentioning

confidence: 99%

Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis

et al. 2008

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-Visceral leishmaniasis is the most important zoonosis in Europe and it is caused by Leishmania infantum, a protozoan intracellular parasite. Canine visceral leishmaniasis (CVL) is endemic in the Mediterranean basin, Middle East, and South America, and is emerging within non endemic areas such as the United Kingdom and North America. We have analyzed 24 polymorphisms in the canine Slc11a1 (formerly NRAMP1) gene: 19 new polymorphisms characterized by direct sequencing from 40 dogs of different breeds and five polymorphisms previously described. Data analysis in a case-control study including 164 dogs of 19 different breeds revealed that two of the 24 polymorphisms were associated with increased risk for CVL: one intronic single nucleotide polymorphism (SNP) (A4549G in intron 6: odds ratio (OR) = 6.78, P = 0.001) and one silent SNP in exon 8 (C4859T: OR = 13.44, P = 0.004). In silico analysis of the significant SNP revealed that SNP in the promoter region affect putative transcription binding sites and SNP C4859T in exon 8 disrupts a putative exonic splicing enhancer (ESE). These results corroborate that Slc11a1 polymorphisms are associated with increased risk for CVL. leishmaniasis / Slc11a1 / polymorphism / dog / susceptibility

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“…Leishmaniasis is widespread in tropical and subtropical areas of Latin America, Europe, Africa and Asia and is increasingly becoming a major public health problem (WHO 1999). An increased prevalence of human and canine AVL has been reported in Brazil, not only in terms of the number of cases and but also in terms of the geographical dispersion of the disease (Feitosa et al 2000, Nunes et al 2001, Silva et al 2001, Cabrera et al 2003, França-Silva et al 2003. The disease is more prevalent among dogs than human beings and it has been shown that canine cases usually precede human cases.…”

Section: Introductionmentioning

confidence: 99%

An enzyme-linked immunosorbent assay (ELISA) for the detection of IgM antibodies against Leishmania chagasi in dogs

et al. 2009

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Visceral leishmaniasis is an emergent zoonosis with an increasing number of new cases in Brazil where the domestic dog is an important parasite reservoir in the infectious cycle of Leishmania chagasi. An enzyme-linked immunosorbent assay (ELISA), based upon the use of a total soluble antigenic preparation of L. chagasi, was adapted for the detection of IgM antibodies in the serum of infected dogs. Optimal dilutions of the antigen, using positive and negative reference sera, were determined by checkboard titrations. The specificity and sensitivity of the ELISA were 100 %. A total of 110 serum samples were taken from dogs in Belo Horizonte, Minas Gerais, Brazil, and examined for anti-L. chagasi IgM antibody by ELISA and indirect fluorescent antibody test (IFAT). About 25% (n=27) of all the dogs tested were found serologically positive for L. chagasi by IFAT, while 89.09% (n=98) were seropositive by ELISA. The results obtained by ELISA and IFAT were significantly different (P<0.01). The combined use of ELISA and IFAT is recommended in order to enable veterinary services to more efficiently detect canine visceral leishmaniasis.INDEX TERMS: Leishmania chagasi, diagnosis, dogs, IgM, enzyme-linked immunosorbent assay.

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Epidemiology of canine visceral leishmaniosis in the endemic area of Montes Claros Municipality, Minas Gerais State, Brazil

Cited by 147 publications

References 16 publications

Leishmaniose visceral: estudo de flebotomíneos e infecção canina em Montes Claros, Minas Gerais

Leishmaniose visceral: estudo de flebotomíneos e infecção canina em Montes Claros, Minas Gerais

Slc11a1 (formerly Nramp1) and susceptibility to canine visceral leishmaniasis

An enzyme-linked immunosorbent assay (ELISA) for the detection of IgM antibodies against Leishmania chagasi in dogs

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