Epidemiology of Candidemia in Children over 7 Years in a Medical Center in Turkey

Yilmaz-Ciftdogan, Dilek; Aksay, Ahu Kara; Erbaş, Gülcan; Sarkış, Ümit Başak; Karadağ‐Öncel, Eda; Anıl, Ayşe Berna; Baran, Maşallah; Er, Halil; Yılmaz, Nisel

doi:10.1128/spectrum.00453-21

Cited by 9 publications

(10 citation statements)

References 35 publications

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“…Candidaalbicans was the most prevalent species, followed by C. parapsilosis among candidemia patients, according to many reports in the literature (6,9). On the contrary, C. parapsilosis has been reported as the most commonly isolated Candida strain in other studies (10,11).…”

Section: Discussionmentioning

confidence: 97%

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Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Arabacı¹,

Aydemir²,

Ak³

et al. 2023

Jundishapur J Microbiol

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Background: Candida infections are a significant cause of morbidity and mortality in hospitalized patients. Acquired resistance to antifungal agents and strains with intrinsic resistance makes it hard to manage the infection. Objectives: We aimed to examine the risk factors of candidemia associated with patient mortality, the species causing candidemia, and their antifungal susceptibility. Methods: Patient data were collected from medical records retrospectively. MALDI-TOF MS was used to identify Candida species. Antifungal susceptibility testing was conducted by the colorimetric broth microdilution method. Results: A total of 155 patients were included in the study. The incidences of candidemia were 0.92, 0.72, 0.99, 0.97, and 2.28 per 1,000 cases in 2016, 2017, 2018, 2019, and 2020, respectively. Candida albicans accounted for 45% of all cases, followed by C. parapsilosis complex (28%), C. tropicalis (10%), and C. glabrata (8%). The 30-day crude mortality was 45%. There was no significant difference in mortality between C. albicans and non-albicans yeast species. The susceptibility rates for anidulafungin, micafungin, caspofungin, voriconazole, and fluconazole were as follows: 97%, 97%, 97%, 97%, and 90% in C. albicans, 95%, 95%, 98%, 72%, and 67% in C. parapsilosis complex, and 100%, 100%, 100%, 38%, and 63% in C. tropicalis. The susceptibility rates for anidulafungin, micafungin, and caspofungin in C. glabrata were 100%, 100%, and 92%, respectively. All 12 C. glabrata strains were susceptible-dose-dependent against fluconazole and uninterpretable for voriconazole. Conclusions: Incidences of candidemia and susceptibility patterns of strains may vary over time and amongst the regions. Candida albicans was the predominant strain, and echinocandins demonstrated the highest susceptibility rates against the most common species isolated in this study. Antifungal susceptibility tests are crucial in guiding patient treatment.

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Section: Discussionmentioning

confidence: 97%

“…Additionally, 57% of the patients were hospitalized in the intensive care unit. The incidence rate reported from Turkey in the literature ranges from 0.56 to 11.5 per 1000 admissions (1,10,16,17). The literature data indicated that ICU patients had higher candidemia risk and mortality than general ward patients (4).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Arabacı¹,

Aydemir²,

Ak³

et al. 2023

Jundishapur J Microbiol

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“…Amphotericin B resistance was found in 1.3% of all isolates. Ciftdogan et al 35 reported that out of 71 C. parapsilosis isolates in children with candidemia, 33.8% were resistant to fluconazole. We detected fluconazole resistance in 9.5% of CA isolates, which was similar to previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Amphotericin B resistance was found in 1.3% of all isolates. Ciftdogan et al35 reported that out of 71 C. parapsilosis isolates in children with…”

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confidence: 99%

Evaluation of candidemia in children at a university hospital: A retrospective cohort

Özenen

Bal

Avcu

et al. 2023

Mycoses

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Despite improvements in diagnosis and treatment, candidemia remains a major cause of mortality and morbidity in hospitalised paediatric patients. 1,2 Candidemia causes a global public health concern due to prolonged hospital stays, high mortality rates, and increased costs, resulting in additional economic burden. 3,4 Over the years, Candida albicans (CA) has been the most common species, but there has been an increase in the prevalence of non-albicans Candida (NAC) spp. in recent years, including C. parapsilosis, C. glabrata, C. krusei, and C. tropicalis. 1

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“…Candidemia is an important opportunistic infection in pediatric populations at risk, mainly neonates and those with hematologic malignancies [ 42 ] and patients in mechanical ventilatory support and immunosuppressive therapy [ 43 ]. However, risk factors for candidemia may vary according to patient populations and fungal etiology, which brings challenges to clinical diagnosis [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical, Epidemiological and Laboratory Features of Invasive Candida parapsilosis Complex Infections in a Brazilian Pediatric Reference Hospital during the COVID-19 Pandemic

Peixoto

Silva

Portela

et al. 2023

JoF

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The present study aimed to describe the clinical, epidemiological and laboratory characteristics of invasive candidiasis by C. parapsilosis complex (CPC) in a Brazilian tertiary pediatric hospital during the COVID-19 pandemic. Clinical samples were processed in the BACT/ALERT® 3D system or on agar plates. Definitive identification was achieved by MALDI-TOF MS. Antifungal susceptibility was initially analyzed by the VITEK 2 system (AST-YS08 card) and confirmed by the CLSI protocol. Patient data were collected from the medical records using a structured questionnaire. CPC was recovered from 124 patients over an 18-month period, as follows: C. parapsilosis (83.87%), C. orthopsilosis (13.71%) and C. metapsilosis (2.42%). Antifungal resistance was not detected. The age of the patients with invasive CPC infections ranged from <1 to 18 years, and most of them came from oncology-related sectors, as these patients were more affected by C. parapsilosis. C. orthopsilosis infections were significantly more prevalent in patients from critical care units. Invasive infections caused by different pathogens occurred in 75 patients up to 30 days after the recovery of CPC isolates. Overall, 23 (18.55%) patients died within 30 days of CPC diagnosis. Catheter removal and antifungal therapy were important measures to prevent mortality. COVID-19 coinfection was only detected in one patient.

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Epidemiology of Candidemia in Children over 7 Years in a Medical Center in Turkey

Cited by 9 publications

References 35 publications

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Epidemiology, Antifungal Susceptibility, and Risk Factors of Invasive Candidiasis in a Tertiary Hospital During a Four-Year Period

Evaluation of candidemia in children at a university hospital: A retrospective cohort

Clinical, Epidemiological and Laboratory Features of Invasive Candida parapsilosis Complex Infections in a Brazilian Pediatric Reference Hospital during the COVID-19 Pandemic

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