Epidemiology of Candida isolates from Intensive Care Units in Colombia from 2010 to 2013

Gabriel, Marcin; Muñoz, Juan Sebastián; Oñate, José Millán; Pallares, Christian; Hernández, Cristhian; Villegas, María Virginia

doi:10.1016/j.riam.2016.02.006

Cited by 23 publications

(21 citation statements)

References 47 publications

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“…The global impact of Candida infections is enormous ( Quindós, 2014 ; Enoch et al, 2017 ) although the epidemiology of the species involved in the invasive diseases is constantly changing as it depends on many factors including the geographical region considered, patient population, antifungal prophylaxis, diagnostic tests, and local hospital-related characteristics ( Guinea, 2014 ; Quindós, 2014 ; Caggiano et al, 2015 ; Prigitano et al, 2016 ; Enoch et al, 2017 ; Epelbaum and Chasan, 2017 ). In this context, C. tropicalis has emerged as the predominant NAC species causing candidemia, especially in East Asian and Latin American countries ( Yesudhason and Mohanram, 2015 ; Wang et al, 2016 ; da Matta et al, 2017 ; Motoa et al, 2017 ; Wu et al, 2017 ). In these countries, an extraordinary high incidence of C. tropicalis has also been recently reported from natural environments and animals ( Chi et al, 2012 ; Brilhante et al, 2015 ; Cordeiro Rde et al, 2015 ; Zuza-Alves et al, 2016 ) by representing a potential threat to humans living in these geographical areas.…”

Section: Discussionmentioning

confidence: 99%

“…Among the different NAC species, C. tropicalis is of particular importance as it emerged as a major cause of nosocomial candidemia in the elderly worldwide, particularly in the Asia-Pacific region and Latin America ( Kothavade et al, 2010 ; Negri et al, 2012 ; Quindós, 2014 ; Motoa et al, 2017 ; Pu et al, 2017 ). This fungus is, generally, less often encountered in the rest of the world ( Quindós, 2014 ) but recent surveillance studies in Italy revealed that this species accounts for 6–16.4% of the candidemia cases ( Bassetti et al, 2013 ; Montagna et al, 2013 ; Caggiano et al, 2015 ; Tedeschi et al, 2016 ; De Francesco et al, 2017 ) by representing a relevant issue given the high mortality associated with its infections ( Muñoz et al, 2011 ; Negri et al, 2012 ; Caggiano et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Multilocus Sequence Typing Reveals a New Cluster of Closely Related Candida tropicalis Genotypes in Italian Patients With Neurological Disorders

et al. 2018

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Candida tropicalis is a pathogenic yeast that has emerged as an important cause of candidemia especially in elderly patients with hematological malignancies. Infections caused by this species are mainly reported from Latin America and Asian-Pacific countries although recent epidemiological data revealed that C. tropicalis accounts for 6–16.4% of the Candida bloodstream infections (BSIs) in Italy by representing a relevant issue especially for patients receiving long-term hospital care. The aim of this study was to describe the genetic diversity of C. tropicalis isolates contaminating the hands of healthcare workers (HCWs) and hospital environments and/or associated with BSIs occurring in patients with different neurological disorders and without hematological disease. A total of 28 C. tropicalis isolates were genotyped using multilocus sequence typing analysis of six housekeeping (ICL1, MDR1, SAPT2, SAPT4, XYR1, and ZWF1) genes and data revealed the presence of only eight diploid sequence types (DSTs) of which 6 (75%) were completely new. Four eBURST clonal complexes (CC2, CC10, CC11, and CC33) contained all DSTs found in this study and the CC33 resulted in an exclusive, well-defined, clonal cluster from Italy. In conclusion, C. tropicalis could represent an important cause of BSIs in long-term hospitalized patients with no underlying hematological disease. The findings of this study also suggest a potential horizontal transmission of a specific C. tropicalis clone through hands of HCWs and expand our understanding of the molecular epidemiology of this pathogen whose population structure is still far from being fully elucidated as its complexity increases as different categories of patients and geographic areas are examined.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multilocus Sequence Typing Reveals a New Cluster of Closely Related Candida tropicalis Genotypes in Italian Patients With Neurological Disorders

et al. 2018

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“…Fungal infections have emerged worldwide, accounting for about 6% of all healthcare-associated infections (HAIs), especially in the increasing population of immunocompromised patients [1][2][3][4][5]. Invasive candidiasis and candidemia represent a serious public health problem associated with high mortality rates, ranging from 40 to 85%, prolonged length of hospital stay and high costs [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Promising antifungal activity of new oxadiazole against Candida krusei

et al. 2020

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Candida krusei is one of the most common agents of invasive candidiasis and candidemia worldwide, leading to high morbidity and mortality rates. This species has become a problem due to its intrinsic resistance and reduced susceptibility to azoles and polyenes. Moreover, the number of antifungal drugs available for candidiasis treatment is limited, demonstrating the urgent need for the discovery of novel alternative therapies. In this work, the in vivo and in vitro activities of a new oxadiazole (LMM11) were evaluated against C. krusei. The minimum inhibitory concentration ranged from 32 to 64 μg/mL with a significant reduction in the colony forming unit (CFU) count (~3 log 10). LMM11 showed fungicidal effect, similar to amphotericin, reducing the viable cell number (>99.9%) in the time-kill curve. Yeast cells presented morphological alterations and inactive metabolism when treated with LMM11. This compound was also effective in decreasing C. krusei replication inside and outside macrophages. A synergistic effect between fluconazole and LMM11 was observed. In vivo treatment with the new oxadiazole led to a significant reduction in CFU (0.85 log 10). Furthermore, histopathological analysis of the treated group exhibited a reduction in the inflammatory area. Taken together, these results indicate that LMM11 is a promising candidate for the development of a new antifungal agent for the treatment of infections caused by resistant Candida species such as C. krusei.

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“…A significant trend towards an increased number of cases of candidemia has been noted [10]. There has been also a shift in the number or cases caused by Candida albicans in contrast to non- C. albicans cases, with more recent studies showing an increase in the cases of C. tropicalis , C. parapsillopsis , and C. glabrata [4,45,46,47]. A low frequency of fluconazole resistance has been observed among the three main identified species [4].…”

Section: Resultsmentioning

confidence: 99%

Burden of Fungal Infections in Colombia

Álvarez-Moreno

Cortés

Denning

2018

JoF

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Data with respect to the epidemiological situation of fungal diseases in Colombia is scarce. Thus, the aim of this study is to estimate the burden of fungal infections. A population projection for 2017 from the Colombian Department for National Statistics was used, as well as official information from the Ministry of Health and National Institute of Health. A bibliographical search for Colombian data on mycotic diseases and population at risk (chronic obstructive pulmonary disease, HIV infection/AIDS, cancer, and transplant patients) was done. The Colombian population for 2017 was estimated at 49,291,609 inhabitants, and the estimated number of fungal infections for Colombia in 2017 was between 753,523 and 757,928, with nearly 600,000 cases of candidiasis, 130,000 cases of aspergillosis, and 16,000 cases of opportunistic infection in HIV, affecting around 1.5% of the population. In conclusion, fungal infections represent an important burden of disease for the Colombian population. Different clinical, epidemiological, and developmental scenarios can be observed in which fungal infections occur in Colombia.

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Epidemiology of Candida isolates from Intensive Care Units in Colombia from 2010 to 2013

Cited by 23 publications

References 47 publications

Multilocus Sequence Typing Reveals a New Cluster of Closely Related Candida tropicalis Genotypes in Italian Patients With Neurological Disorders

Multilocus Sequence Typing Reveals a New Cluster of Closely Related Candida tropicalis Genotypes in Italian Patients With Neurological Disorders

Promising antifungal activity of new oxadiazole against Candida krusei

Burden of Fungal Infections in Colombia

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