Epidemiology of bloodstream infections and surface swab cultures in burn patients

Kaita, Yasuhiko; Otsu, Akiyasu; Tanaka, Yuya; Yoshikawa, Kei; Matsuda, Takeshi; Yamaguchi, Yoshihiro

doi:10.1002/ams2.752

Cited by 4 publications

(3 citation statements)

References 18 publications

(35 reference statements)

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“…In our study, S. aureus was the most common bacterial organism colonizing burn wounds, accounting for 15.7% of all isolates. Similar findings have been reported in other epidemiological studies of burn wound infections [ 15 ], while some other studies report P. aeruginosa as the predominant organism [ 18 , 19 ]. In fact, both of them are common pathogens detected in BWI [ 11 ].…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, we discovered that the strains originating from BWI exhibit notable dissimilarities throughout the patient’s admission, as indicated by the results of swab cultures. These findings could aid in predicting the causative agents of BSI in burn patients [ 18 ]. Burn centers are advised to identify predominant microbial isolates at their facility and track changes in the microbiology of burn wounds, including antibiotic resistance.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Zhou,

Xiao,

Wang

et al. 2023

Antibiotics

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Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was Staphylococcus aureus (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Zhou,

Xiao,

Wang

et al. 2023

Antibiotics

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“…Our findings are mostly in line with the literature. Kaita et al reported that the most frequently isolated organisms in their study were fungi, specifically candida species [ 23 ]. Brusselaers et al reported that 13.2% of positive blood cultures were positive for Candida [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Stream Infections in Burns: A 14-Year Cohort Analysis

Nitsani,

Michael,

Halpern

et al. 2023

Life

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Background: Blood stream infections are a significant cause of morbidity and mortality in burns, and pathogen identification is important for treatment. This study aims to characterize the microbiology of these infections and the association between the infecting pathogen and the hospitalization course. Methods: We conducted a cohort study that included records of burn patients treated at the Soroka University Medical Center between 2007–2020. Statistical analysis of demographic and clinical data was performed to explore relationships between burn characteristics and outcomes. Patients with positive blood cultures were divided into four groups: Gram-positive, Gram-negative, mixed-bacterial, and fungal. Results: Of the 2029 burn patients hospitalized, 11.7% had positive blood cultures. The most common pathogens were Candida and Pseudomonas. We found significant differences in ICU admission, need for surgery, and mortality between the infected and non-infected groups (p < 0.001). Pathogen groups differed significantly mean TBSA, ICU admission, need for surgery, and mortality (p < 0.001). Multivariate analysis showed flame (OR 2.84) and electric burns (OR 4.58) were independent risk factors for ICU admission and surgical intervention (p < 0.001). Gram-negative bacterial infection was found to be an independent predictor of mortality (OR = 9.29, p < 0.001). Conclusions: Anticipating specific pathogens which are associated with certain burn characteristics may help guide future therapy.

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Multidrug-Resistant Organisms: The Silent Plight of Burn Patients

Elsheikh,

Makram

2024

Journal of Burn Care &Amp; Research

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The global increasing spread of multidrug-resistant organisms (MRDOs) is threatening the control of various infections in vulnerable populations and patient groups. One of the most affected groups is burn patients, who are prone to hyperinfection as they suffer from a hypermetabolic state and weakened immune barriers. Those patients also share the infection risk of patients hospitalized for a long time, including ventilator-associated pneumonia and urinary tract infections. While some preventative and therapeutic management styles are still controversial, there are some consensuses that we discuss here. In this review, we aim to present the current knowledge on multidrug-resistance with a special focus on burn patients, discuss various causative organisms and their treatment options, and highlight the importance of antibiotic stewardship and teamwork in responding to an outbreak of MDROs.

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Epidemiology of bloodstream infections and surface swab cultures in burn patients

Cited by 4 publications

References 18 publications

Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China

Blood Stream Infections in Burns: A 14-Year Cohort Analysis

Multidrug-Resistant Organisms: The Silent Plight of Burn Patients

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