Epidemiology of Bloodstream Candida spp. Infections Observed During a Surveillance Study Conducted in Spain

Cisterna, R; Ezpeleta, Guillermo; Tellería, O.

doi:10.5772/32288

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Majority of the Candida responded well to the antifungal drugs investigated in this study. However, the finding of some resistant Candida isolates here is supported by studies that reported trends of increasing resistance to antifungal agents amongst some Candida infections [ (Cisterna, Ezpeleta, & Tellería, 2005), (Ingham et al, 2012)].…”

Section: Antifungal Susceptibility Profilessupporting

confidence: 79%

Prevalence, Distribution, Risk Factors and Antifungal Susceptibility Profiles of Candida Isolates from Patients Attending Mombasa Hospital

2018

IST Journal

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Candida commonly occurs as commensal organisms on the mucosal surfaces of gastrointestinal, genitourinary tracts and skin of humans but can cause mucocutaneous or invasive infections [(Pappas et al., 2004), (Kabir & Ahmad, 2013), (Mayer, Wilson, & Hube, 2013)]. Candida are emerging as a potentially pathogenic fungus in patients with broncho-pulmonary diseases (Kali et al., 2013). 2. Problem Statement Most laboratories in Mombasa do not undertake Candida identification and antifungal susceptibility tests although the Vitek (BioMérieux) system enables clinical laboratories to perform routine identification of Candida and antifungal susceptibility easier and more accurately (Melhem et al., 2013). Various Candida species (Mainly mucocutaneous but also few cases of systemic Candida infections) are isolated from clinical specimens in the Microbiology laboratory at Mombasa Hospital with few cases of resistance to some antifungal agents identified (Mombasa hospital health management information system). 3. Research Objective The study was guided by the following specific objectives: i. To determine the prevalence and distribution of Candida species among patients attending Mombasa Hospital. ii. To determine the antifungal susceptibility profiles of the Candida isolated from clinical specimens in Mombasa Hospital. iii. To determine the risk factors associated with isolation of Candida among patients attending Mombasa Hospital

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Section: Antifungal Susceptibility Profilessupporting

confidence: 79%

Prevalence, Distribution, Risk Factors and Antifungal Susceptibility Profiles of Candida Isolates from Patients Attending Mombasa Hospital

2018

IST Journal

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“…C. parapsilosis was the second most common (15.2%) species isolated in our centre, as was reported at even higher rates (>20%) in recent studies conducted in Italy, Spain and South America. [35][36][37][38][39][40][41][42][43][44][45][46] Conversely, C. glabrata was the second most common species in North America and other parts of Europe. 16,18,21,[27][28][29][30][31][32][33][34]47,48 The isolation ratio of C. tropicalis (13.4%) in our study was slightly higher than in the European (2-10%) and North American series (9-12%), but lower than stated in reports (>15%) from the Middle East, South America, East Asia and Southeast Asia.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of candidaemia in a tertiary care university hospital: 10‐year experience with 381 candidaemia episodes between 2001 and 2010

Alp

Arıkan-Akdağlı

Gülmez

et al. 2015

Mycoses

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Defining the epidemiology of and risk factors for candidaemia is necessary to guide empirical treatment. The objectives of this study were to determine the ranking of Candida among positive blood cultures, to define the epidemiology of candidaemia and to investigate patient characteristics and their relationship with C. albicans vs. non-albicans Candida (NAC) candidaemia. Candidaemia episodes between January 2001 and December 2010 were evaluated retrospectively. Patient characteristics were compared across Candida species. Candida ranked as the fifth most frequently isolated pathogen. Among 381 candidaemia episodes, 58.3% were due to C. albicans, followed by C. parapsilosis (15.2%), C. tropicalis (13.4%) and C. glabrata (6.8%). No statistically significant difference was observed in the distribution of C. albicans vs. NAC (P = 0.432). Patients with NAC had significantly higher rates of haematological disorders (P < 0.001) and neutropenia (P = 0.003), and were older (P = 0.024) than patients with C. albicans, whereas patients with urinary catheters had higher rates of C. albicans (P = 0.007). On species basis, C. tropicalis was more frequently isolated from patients with haematological disorders (P < 0.001) and neutropenia (P = 0.008). Patients with urinary catheters were less likely to have C. parapsilosis (P = 0.043). C. glabrata was most prevalent among patients with solid organ tumours (P = 0.038), but not evident in patients with haematological disorders. Local epidemiological features and risk factors may have important implications for the management of candidaemia.

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Epidemiology of Bloodstream Candida spp. Infections Observed During a Surveillance Study Conducted in Spain

Cited by 2 publications

References 46 publications

Prevalence, Distribution, Risk Factors and Antifungal Susceptibility Profiles of Candida Isolates from Patients Attending Mombasa Hospital

Prevalence, Distribution, Risk Factors and Antifungal Susceptibility Profiles of Candida Isolates from Patients Attending Mombasa Hospital

Epidemiology of candidaemia in a tertiary care university hospital: 10‐year experience with 381 candidaemia episodes between 2001 and 2010

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