Epidemiology of blood stream infection in adult extracorporeal membrane oxygenation patients: A cohort study

Menaker, Jay; Galvagno, Samuel M.; Rabinowitz, Ronald; Penchev, Vesselin R.; Hollis, Allison; Kon, Zachary N.; Deatrick, Kristopher B.; Amoroso, Anthony; Herr, Daniel; Mazzeffi, Michael

doi:10.1016/j.hrtlng.2019.01.004

Cited by 36 publications

(51 citation statements)

References 18 publications

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“…Evaluation for infection was done if there was fever, leukocytosis, or purulence at an entry site. 85 Finally, bloodstream infection in extracorporeal membrane oxygenation patients was not associated with in-hospital mortality. 85…”

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 94%

“…84 Large cannulae may be present for prolonged durations and are not easily exchanged if they become infected. 85 Finally, the presence of central lines and arterial catheters for prolonged periods may also increase the risk for bloodstream infection. 85 Gram-negative rods were most frequently isolated from venous arterial-extracorporeal membrane oxygenation patients with bloodstream infection including Aeromonas hydrophilia/caviae, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa.…”

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

“…85 Finally, the presence of central lines and arterial catheters for prolonged periods may also increase the risk for bloodstream infection. 85 Gram-negative rods were most frequently isolated from venous arterial-extracorporeal membrane oxygenation patients with bloodstream infection including Aeromonas hydrophilia/caviae, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. 85 The venous venous-extracorporeal membrane oxygenation patients also had infections with Gram-negative rods including P. aeruginosa, A. baumannii, Burkholderia cepacia, and Enterobacter aerogenes, but they also had Candida infections.…”

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

“…85 Gram-negative rods were most frequently isolated from venous arterial-extracorporeal membrane oxygenation patients with bloodstream infection including Aeromonas hydrophilia/caviae, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa. 85 The venous venous-extracorporeal membrane oxygenation patients also had infections with Gram-negative rods including P. aeruginosa, A. baumannii, Burkholderia cepacia, and Enterobacter aerogenes, but they also had Candida infections. Notably, the venous arterial-extracorporeal membrane oxygenation patients in this study received prophylactic antimicrobial therapy with vancomycin and ceftriaxone for 48 h. All extracorporeal membrane oxygenation patients were bathed with chlorhexidine daily, and central lines are coated with minocycline/rifampin.…”

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

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Controversies in Perioperative Antimicrobial Prophylaxis

et al. 2020

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Although clinical guidelines for antibiotic prophylaxis across a wide array of surgical procedures have been proposed by multidisciplinary groups of physicians and pharmacists, clinicians often deviate from recommendations. This is particularly true when recommendations are based on weak data or expert opinion. The goal of this review is to highlight certain common but controversial topics in perioperative prophylaxis and to focus on the data that does exist for the recommendations being made.

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Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 94%

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

Section: Bloodstream Infections In Extracorporeal Membrane Oxygenatiomentioning

confidence: 99%

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Controversies in Perioperative Antimicrobial Prophylaxis

et al. 2020

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“… 14 - 16 Previous studies have also found an association between renal failure and BSIs in patients with veno-venous ECMO as well as a relationship between hepatic failure and BSIs in patients with veno-arterial ECMO. 17 There are several explanations for these results. First, invasive procedures, medication, electrolyte disorders, and blood infusion may increase the risk of bacterial contamination.…”

Section: Discussionmentioning

confidence: 99%

Bloodstream infections in patients undergoing extracorporeal membrane oxygenation

et al. 2020

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Objective: We aimed to evaluate the incidence, risk factors, and prognosis of bloodstream infections (BSIs) during extracorporeal membrane oxygenation (ECMO) treatment in a Chinese population. Methods: Patients receiving ECMO treatment from January 2013 to August 2019 were retrospectively studied. The incidence of BSIs was calculated. The clinical characteristics between patients with a BSI (BSI group) and without a BSI (non-BSI group) Results: Among 69 included patients, 19 (27.5%) developed at least one BSI. Gram-negative bacteria (73.7%) were mainly responsible for the BSIs, with Klebsiella pneumoniae (6/19, 31.5%) ranking as the top related pathogen. The BSI group had a greater proportion of methicillin-resistant Staphylococcus aureus (MRSA) prophylactic regimens (52.6% vs. 26.0%, P = 0.036), a higher pre-ECMO Sequential Organ Failure Assessment (SOFA) score (11 vs. 8, P = 0.008), more applications of continuous renal replacement therapy (CRRT) during ECMO (63.1% vs. 36.1%, P = 0.042). Longer ECMO support duration, period of ventilator use before ECMO weaning and hospital stay were observed in the BSI group. The SOFA score (OR: 1.174; 95% CI: 1.039–1.326; P = 0.010) was an independent risk factor for BSIs. Conclusion: BSIs during ECMO therapy frequently involve Gram-negative bacteria. Stringent care and monitoring should be provided for patients with high SOFA scores. doi: https://doi.org/10.12669/pjms.36.6.2882 How to cite this:Wang JR, Huang JY, Hu W, Cai XY, Hu WH, Zhu Y. Bloodstream infections in patients undergoing extracorporeal membrane oxygenation. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2882 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Infection protection and management during extracorporeal membrane oxygenation

Patroniti

Insorsi

2023

Cardiopulmonary Bypass

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Epidemiology of blood stream infection in adult extracorporeal membrane oxygenation patients: A cohort study

Cited by 36 publications

References 18 publications

Controversies in Perioperative Antimicrobial Prophylaxis

Controversies in Perioperative Antimicrobial Prophylaxis

Bloodstream infections in patients undergoing extracorporeal membrane oxygenation

Infection protection and management during extracorporeal membrane oxygenation

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