2020
DOI: 10.3390/brainsci10050274
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Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

Abstract: The prevalence of Autism Spectrum Disorder (ASD) has increased dramatically in recent decades, supporting the claim of an autism epidemic. Systematic monitoring of ASD allows estimating prevalence and identifying potential sources of variation over time and geographical areas. At present, ASD prevalence estimates are available worldwide, coming either from surveillance systems using existing health and educational databases or from population studies specifically performed. In the present article, we present a… Show more

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Cited by 398 publications
(300 citation statements)
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“…Prevalence studies based on parental or teachers’ reports are subject to significant interviewer or questionnaire-related biases [ 1 , 43 ]. The association between prevalence estimates and source of information is investigated in a review of recent prevalence studies [ 67 ].…”
Section: Discussionmentioning
confidence: 99%
“…Prevalence studies based on parental or teachers’ reports are subject to significant interviewer or questionnaire-related biases [ 1 , 43 ]. The association between prevalence estimates and source of information is investigated in a review of recent prevalence studies [ 67 ].…”
Section: Discussionmentioning
confidence: 99%
“…Because earlier diagnosis improves efficacy of behavioral therapies (3,4), molecular biomarkers represent an attractive approach for identifying 'at-risk' populations and may aid development of personalized therapies. This prospect is increasingly important given the rising rate of ASD diagnoses, which currently stands at up to 1 in 59 children in the United States (2), with high variability of worldwide estimates (~1-2%) (5,6) and no FDA approved drugs for core behavioral symptoms.…”
Section: Introductionmentioning
confidence: 99%
“…With the introduction of improved diagnostic criteria, there has been a substantial rise in the prevalence of autistic cases in the last few decades, reported between three and six children per 1,000 worldwide (Kassim and Mohamed, 2019 ; Lord et al, 2020 ) and 1 in 54 children in the US (Zablotsky et al, 2019 ; Maenner et al, 2020 ). The variability in global prevalence is largely due to differences in methodological assessment and environmental and/or geographical factors (Chiarotti and Venerosi, 2020 ; Lord et al, 2020 ). Both genetic and environmental factors influence the development of ASD and may converge on similar neural outcomes, such as altered connectivity, excitation/inhibition imbalance, and signaling system alterations (Muhle et al, 2004 ; Satterstrom et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%