Epidemiology of Atrial Fibrillation

Zhang, Juqian; Johnsen, Søren Paaske; Guo, Yutao; Lip, Gregory Y. H.

doi:10.1016/j.ccep.2020.10.010

Cited by 68 publications

(10 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Atrial fibrillation (AF) is a global problem, with an increasing incidence and prevalence with an aging population. 1 Similar to Western countries, the prevalence rates of AF will continuously increase in the following decades, which are projected to be 4.0% in Taiwan and 5.4% in South Korea in year 2050 ( Fig. 1 ).…”

Section: Epidemiology Of Af and Risk Of Af-related Strokementioning

confidence: 99%

2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary

et al. 2021

Self Cite

View full text Add to dashboard Cite

The consensus of the Asia Pacific Heart Rhythm Society (APHRS) on stroke prevention in atrial fibrillation (AF) has been published in 2017 which provided useful clinical guidance for cardiologists, neurologists, geriatricians, and general practitioners in the Asia-Pacific region. In these years, many important new data regarding stroke prevention in AF were reported. The practice guidelines subcommittee members comprehensively reviewed updated information on stroke prevention in AF, and summarized them in this 2021 focused update of the 2017 consensus guidelines of the APHRS on stroke prevention in AF. We highlighted and focused on several issues, including the importance of the AF Better Care pathway, the advantages of non-vitamin K antagonist oral anticoagulants (NOACs) for Asians, the considerations of use of NOACs for Asian AF patients with single one stroke risk factor beyond gender, the role of lifestyle factors on stroke risk, the use of oral anticoagulants during the “coronavirus disease 2019” pandemic, etc. We fully realize that there are gaps, unaddressed questions, and many areas of uncertainty and debate in the current knowledge of AF, and the physician's decision remains the most important factor in the management of AF.

show abstract

Section: Epidemiology Of Af and Risk Of Af-related Strokementioning

confidence: 99%

2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…With the increasing age of populations, AF incidence is increasing rapidly worldwide [ 3 ]. The strongest risk factor for AF is old age, along with gender, smoking, alcohol consumption, body mass index, hypertension, left ventricular hypertrophy, significant heart murmur, heart failure, and myocardial infarction [ 4 , 5 ]. However, the etiology and pathophysiologic mechanisms of AF are incompletely understood.…”

Section: Introductionmentioning

confidence: 99%

PDE3A and GSK3B as Atrial Fibrillation Susceptibility Genes in the Chinese Population via Bioinformatics and Genome-Wide Association Analysis

Zhou

Wang

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with uncovered genetic etiology and pathogenesis. We aimed to screen out AF susceptibility genes with potential pathogenesis significance in the Chinese population. Methods: Differentially expressed genes (DEGs) were screened by the Limma package in three GEO data sets of atrial tissue. AF-related genes were identified by combination of DEGs and public GWAS susceptibility genes. Potential drug target genes were selected using the DrugBank, STITCH and TCMSP databases. Pathway enrichment analyses of AF-related genes were performed using the databases GO and KEGG databases. The pathway gene network was visualized by Cytoscape software to identify gene–gene interactions and hub genes. GWAS analysis of 110 cases of AF and 1201 controls was carried out through a genome-wide efficient mixed model in the Fangshan population to verify the results of bioinformatic analysis. Results: A total of 3173 DEGs were identified, 57 of which were found to be significantly associated with of AF in public GWAS results. A total of 75 AF-related genes were found to be potential therapeutic targets. Pathway enrichment analysis selected 79 significant pathways and classified them into 7 major pathway networks. A total of 35 hub genes were selected from the pathway networks. GWAS analysis identified 126 AF-associated loci. PDE3A and GSK3B were found to be overlapping genes between bioinformatic analysis and GWAS analysis. Conclusions: We screened out several pivotal genes and pathways involved in AF pathogenesis. Among them, PDE3A and GSK3B were significantly associated with the risk of AF in the Chinese population. Our study provided new insights into the mechanisms of action of AF.

show abstract

“…In 2019, China can have approximately 28 million stroke sufferers, such as 24 million ischemic strokes [1]. The incidence of AF is growing international due to its excessive occurrence within the elderly and the getting older of the global population [2]. In addition to atrial traumatic inflammation, the chance of a cardiac embolic event (CEA) increases extensively with age [3].…”

Section: Introductionmentioning

confidence: 99%

NT-proBNP Levels and Collateral Circulation Status in Patients with Acute Ischemic Stroke

et al. 2023

View full text Add to dashboard Cite

Background and Objectives. Strokes resulting from atrial fibrillation (AF) increase with age. The relationship between N-terminal- (NT-) prohormone brain natriuretic peptide (NT-proBNP) level and National Institutes of Health Stroke Scale (NIHSS) score is not well established. Also, the collateral circulation plays an important role in NHISS scores. In this study, the effects of NT-proBNP on collateralization were assessed in patients with and without AF. Methods. In this study, 326 hospitalized patients with acute anterior circulation ischemic stroke (AACIS) were included. A comparison of the clinical characteristics of those with and without AF was conducted. The Spearman rank correlation was used for the correlation analysis of plasma NT-proBNP level, regional leptomeningeal collateral (rLMC) score, and computed tomography perfusion (CTP) status in the AF and non-AF groups. An analysis of multivariate linear regression was used to determine how plasma NT-proBNP level, rLMC score, and CTP status influenced the score on the NIHSS. Results. There was a greater plasma NT-proBNP level in the AF group compared with the non-AF group, an increased CTP volume (including CTP ischemic volume, CTP infarct core volume, and CTP ischemic penumbra volume ( P = 0.002 )), higher NIHSS score on admission, and lower rLMC score ( P < 0.001 for the remaining parameters). A negative correlation exists between plasma NT-proBNP level and rLMC score ( r = − 0.156 , P = 0.022 ), but a positive correlation exists between plasma NT-proBNP level and both CTP ischemic volume and CTP infarct core volume ( r = 0.148 , P = 0.003 ) in the AF group, but not in the non-AF group. Multivariate linear regression analysis demonstrated that NT-proBNP, CTP ischemic penumbra volume, and rLMC score were associated with NIHSS score, and NT-proBNP was positively associated with NIHSS scores (95% confidence interval (CI), 0.000-0.002; P = 0.004 ) in the AF group, whatever in the unadjusted model or adjusted models, but not in the nonlarge artery atherosclerosis (LAA) group. Conclusion. In AACIS patients with AF, NT-proBNP level negatively correlated with collateral status, positively with CTP ischemic volume, and positively with NIHSS score.

show abstract

Epidemiology of Atrial Fibrillation

Cited by 68 publications

References 198 publications

2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary

2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary

PDE3A and GSK3B as Atrial Fibrillation Susceptibility Genes in the Chinese Population via Bioinformatics and Genome-Wide Association Analysis

NT-proBNP Levels and Collateral Circulation Status in Patients with Acute Ischemic Stroke

Contact Info

Product

Resources

About