Epidemiology of Antibiotic Resistance in<i>Haemophilus influenzae</i>

Goldstein, F. W.; Acar, J. F.

doi:10.1089/mdr.1995.1.131

Cited by 27 publications

(10 citation statements)

References 27 publications

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“…According to the ampicillin breakpoint of Ն1 µg/ml, 44.4% of -lactamase non-producing H. influenzae strains were found to be intermediately resistant to ABPC. 16,17 The result of this study confirms the impression that -lactamase-negative, ampicillin-resistant (BLNAR) strains are increasingly prevalent among H. influenzae in Japan. 18 CDTR was active against H. influenzae, regardless of whether or not they producedlactamase, whereas CAM had a lower MIC than the breakpoint MIC in all strains.…”

Section: Susceptibility Testingsupporting

confidence: 74%

Antimicrobial activities of cefditoren against respiratory pathogens isolated from children in Japan

Seki

Kasahara

Ohta

et al. 1999

Journal of Infection and Chemotherapy

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Section: Susceptibility Testingsupporting

confidence: 74%

Antimicrobial activities of cefditoren against respiratory pathogens isolated from children in Japan

Seki

Kasahara

Ohta

et al. 1999

Journal of Infection and Chemotherapy

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“…In the light of the above data, the percentage of ␤-lactamase producers among Polish meningitis isolates is not very high, although it is three times higher than found among H. influenzae isolates responsible for lower respiratory tract infections in Poland (28). The observation that antibiotic resistance is more prevalent in encapsulated isolates, responsible for the majority of meningitis cases, than in nontypeable H. influenzae was also revealed by other authors (4,10,32). The results of some studies showed that there is also an increasing number of H. influenzae isolates resistant to chloramphenicol (e.g., Bangladesh, 21.5%; Paraguay, 20%; Cuba, 44%) and an increasing number of isolates resistant simultaneously to both mentioned antibiotics (2,26,31).…”

Section: Discussionmentioning

confidence: 51%

Characteristics of Haemophilus influenzae Type b Responsible for Meningitis in Poland from 1997 to 2004

et al. 2005

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Two hundred forty-five H. influenzae isolates responsible for meningitis in Poland from 1997 to 2004 were studied. Among these, 233 (95.1%) belonged to serotype b (Hib), 2 belonged to serotype f, and 10 were noncapsulated. The relatedness of all isolates was evaluated by pulsed-field gel electrophoresis (PFGE), and selected representatives were evaluated by multilocus sequence typing. Resistance to ampicillin was identified in 34 (14.6%) of the Hib isolates and was associated with the production of ␤-lactamase only. Except for four isolates nonsusceptible to chloramphenicol, all isolates were susceptible to cefotaxime, ciprofloxacin, and rifampin. The PFGE analysis divided the Hib isolates into five PFGE types; however, all of them were possibly related. The most common PFGE type, with 25 subtypes, was characteristic for 97.4% of the isolates. The most prevalent PFGE subtype found in our study was also the most common among the Hib isolates responsible for invasive disease in Italy and the Czech Republic and was found among isolates causing lower respiratory tract infections in Poland. The most prevalent sequence types (STs) in the studied group were ST6 and ST92. Four new STs were found: ST188, ST189, ST190, and ST268. Results of this study support the evidence that the genetic structure of encapsulated H. influenzae is clonal. The continuing high number of meningitis cases due to Hib in Poland underlines the need for mass vaccination against Hib in Poland.

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“…There is often an association between high frequencies of ß-lactamase and production of the type b capsule and isolated meningitis strains, especially among patients aged 6 months to 6 years (12,22). Our isolates showed a 95.9% frequency of type b strains and an 87.4% frequency of samples isolated from cerebrospinal fluid.…”

Section: Discussionmentioning

confidence: 55%

Antimicrobial resistance among invasive Haemophilus influenzae strains: results of a Brazilian study carried out from 1996 through 2000

Casagrande

Landgraf

Kobata

et al. 2002

Braz J Med Biol Res

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A total of 1712 strains of Haemophilus influenzae isolated from patients with invasive diseases were obtained from ten Brazilian states from 1996 to 2000. ß-Lactamase production was assessed and the minimum inhibitory concentrations (MIC) of ampicillin, chloramphenicol, ceftriaxone and rifampin were determined using a method for broth microdilution of Haemophilus test medium. The prevalence of strains producing ß-lactamase ranged from 6.6 to 57.7%, with an overall prevalence of 18.4%. High frequency of ß-lactamase-mediated ampicillin resistance was observed in Distrito Federal (25%), São Paulo (21.7%) and Paraná (18.5%). Of the 1712 strains analyzed, none was ß-lactamase negative, ampicillin resistant. A total of 16.8% of the strains were resistant to chloramphenicol, and 13.8% of these also presented resistance to ampicillin, and only 3.0% were resistant to chloramphenicol alone. All strains were susceptible to ceftriaxone and rifampin and the MIC 90 were 0.015 µg/ml and 0.25 µg/ml, respectively. Ceftriaxone is the drug of choice for empirical treatment of bacterial meningitis in pediatric patients who have not been screened for drug susceptibility. The emergence of drug resistance is a serious challenge for the management of invasive H. influenzae disease, which emphasizes the fundamental role of laboratory-based surveillance for antimicrobial resistance.

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Epidemiology of Antibiotic Resistance inHaemophilus influenzae

Cited by 27 publications

References 27 publications

Antimicrobial activities of cefditoren against respiratory pathogens isolated from children in Japan

Antimicrobial activities of cefditoren against respiratory pathogens isolated from children in Japan

Characteristics of Haemophilus influenzae Type b Responsible for Meningitis in Poland from 1997 to 2004

Antimicrobial resistance among invasive Haemophilus influenzae strains: results of a Brazilian study carried out from 1996 through 2000

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