Epidemiology of Angioedema without Wheels in an Allergy and Immunology Clinic

Malbrán, Eloisa; Malbrán, Alejandro; Romero, Diego; Juri, María Cecilia; Larrauri, Blas

doi:10.1016/j.jaci.2014.12.1585

Cited by 5 publications

(8 citation statements)

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“…However, in the Mansi et al 15 study, the most frequent etiology was idiopathic AE (42%) and ACEi induced AE was the third most frequent etiology (27%). These findings are also in line with the study by Malbrán et al, 17 that characterized 280 hospitalization episodes due to AE without urticaria and found that idiopathic AE was the most frequent etiology (55.7%) followed by drug induced AE episodes (24.3%) and by HAE in 15.7% of the cases. In our opinion, the high frequency of HAE in our population may be explained by the fact that CHULN is a national reference center for the follow-up of patients with this disease.…”

Section: Discussionsupporting

confidence: 92%

Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

Cosme¹,

Spínola²,

Ferreira³

et al. 2019

Acta Med Port

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Introduction: Hospitalizations due to angioedema are important especially in debilitating or life-threatening situations. The aim of this study was to evaluate the frequency and etiology of angioedema without urticaria in hospital admissions.Material and Methods: The admissions between 2009 and 2013 in Centro Hospitalar Lisboa Norte with a diagnosis grouped under the ICD9 codes of angioedema were retrospectively analysed. The episodes of angioedema with urticaria were excluded. The admissions were categorized into 2 groups: A — hospitalizations motivated by the angioedema; B — hospitalizations in which the angioedema was an incidental finding.Results: There were 169 hospitalizations (52% females, 96% adults, mean age 52 ± 20.8 years), distributed by 23 hospital departments, 51% in the Immunoallergology department. The mean annual angioedema admission rate was 72/100 000. In 68% of the cases, angioedema was the cause for the admission; in 32% an incidental finding. In 38% there was upper airway involvement. The etiologies were: hereditary angioedema in 24%, angiotensin converting enzyme inhibitor induced angioedema in 31%, idiopathic angioedema in 21%, thrombolysis induced angioedema in 13%, nonsteroidal anti-inflammatory drug-induced angioedema in 5%.Discussion: The main etiology was angiotensin converting enzyme inhibitor angioedema, followed by hereditary angioedema and thrombolysis induced angioedema, and these findings concur with the international literature.Conclusion: The mean annual angioedema admission rate was 72/100 000 and there was airway involvement in 38% of hospitalizations.

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Section: Discussionsupporting

confidence: 92%

Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

Cosme¹,

Spínola²,

Ferreira³

et al. 2019

Acta Med Port

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“…Angioedema without urticaria was the most common mucocutaneous disorder. The majority of patients was diagnosed with idiopathic angioedema, which is in line with published data in younger cohorts (17). ACE inhibitors/ARB-induced angioedema represented the second most common cause of angioedema without urticaria in our sample, with a higher frequency compared to other published studies (17,18).…”

Section: Discussionsupporting

confidence: 91%

“…However, the frequency of non-allergic rhinitis and bronchial asthma was higher in females, as previously published (33). ACE inhibitors/ ARB-induced angioedema was more common in males, in line with previously reported data (18) and against what was found in younger ages (17,34).…”

Section: Discussionsupporting

confidence: 91%

“…The majority of patients was diagnosed with idiopathic angioedema, which is in line with published data in younger cohorts (17). ACE inhibitors/ARB-induced angioedema represented the second most common cause of angioedema without urticaria in our sample, with a higher frequency compared to other published studies (17,18). Most patients had this clinical presentation in response to an ACE inhibitor, and a considerable percentage tolerated an ARB as an alternative drug.…”

Section: Discussionsupporting

confidence: 90%

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Immunoallergic disorders in the elderly

Martins-dos-Santos

Araujo

Prates

et al. 2022

Eur Ann Allergy Clin Immunol

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Although allergic diseases have become increasingly prevalent in the elderly, there are few data on this population. Through a retrospective analysis of the electronic medical records of patients aged 65 years and above followed in our Immunoallergology Unit, we aimed to characterize the immunoallergic diseases of the elderly. The most common disorders were respiratory diseases (n = 185; 50%), mucocutaneous diseases (n = 113; 31%), drug allergy (n = 31; 8%), food allergy (n = 9; 2%), and anaphylaxis (n = 9; 2%). Use of specific immunotherapy was residual (n = 2; 1%). There was an association between anaphylaxis and both, drug (p = 0.004) and food (p = 0.013) allergies. Non-allergic rhinitis and bronchial asthma were more frequent in females, and Angiotensin-converting-enzyme (ACE) inhibitors/ Angiotensin II receptor blockers (ARB) induced-angioedema in males. Recognizing the characteristics of immunoallergic diseases in the elderly and the specificities of this age group is paramount in providing these patients with the best possible care. Impact statementImmunoallergic diseases in the elderly have specificities that clinicians must be aware of in order to provide these patiens with the best care.

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“…1 , Table 2 ). Generally, the incidence of drug-induced angioedema has been reported as higher in females 25 , 26 , and older age has been associated with a higher incidence of angioedema 27 , which supports our results.…”

Section: Discussionsupporting

confidence: 91%

Pharmacovigilance study of the association between dipeptidyl peptidase–4 inhibitors and angioedema using the FDA Adverse Event Reporting System (FAERS)

Ohyama

Shindo

Takahashi

et al. 2022

Sci Rep

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Dipeptidyl peptidase-4 (DPP-4) plays a minor role in degrading vasoactive peptides that cause angioedema when angiotensin-converting enzyme (ACE) is present and fully functional. This study investigated the association between DPP-4 inhibitors (DPP-4Is) and angioedema, including cases where the concomitant use of ACE inhibitors (ACEIs) was absent. We obtained data from the US Food and Drug Administration Adverse Event Reporting System and performed a disproportionality analysis, using the reporting odds ratio (ROR) and information component (IC) for signal detection in patients aged ≥ 40 years, stratified by age group and sex. No signal was detected for DPP-4Is when the entire dataset was analyzed. However, a signal was detected for the entire female subset group, the three stratified female groups aged ≥ 60 years, and males in their 40 s. After excluding the data of concomitant ACEI users, most ROR and IC values were lower and significant only for females in their 60 s and males aged ≥ 80 years. Regarding individual DPP-4Is signals, those detected for saxagliptin and sitagliptin in some age groups disappeared after excluding the data of ACEI users. Notably, linagliptin was the only DPP-4I where signals were detected in most female groups, regardless of age and without concomitant ACEI use. Our findings suggest that some DPP-4Is were associated with a higher reporting of angioedema as per age and sex, even in the absence of concomitant ACEI use.

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Epidemiology of Angioedema without Wheels in an Allergy and Immunology Clinic

Cited by 5 publications

References 0 publications

Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

Hospitalizations due to Angioedema without Urticaria in a Portuguese Center: Five Year Retrospective Study

Immunoallergic disorders in the elderly

Pharmacovigilance study of the association between dipeptidyl peptidase–4 inhibitors and angioedema using the FDA Adverse Event Reporting System (FAERS)

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