Epidemiology of amyotrophic lateral sclerosis: A review of literature

Couratier, Philippe; Corcia, Philippe; Lautrette, Géraldine; Nicol, M.; Preux, Pierre‐Marie; Marin, Benoît

doi:10.1016/j.neurol.2015.11.002

Cited by 105 publications

(90 citation statements)

References 74 publications

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“…The age groups 60-69 years and 70-79 years are the most common ages of diagnosis and those aged 18-39 years are the least. This finding is consistent with reported literature in the United States and abroad (1,6,(36)(37)(38)(39)(40)(41)(42)(43).…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Mehta

Kaye

Bryan

et al. 2016

MMWR Surveill. Summ.

120

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Section: Discussionsupporting

confidence: 93%

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Mehta

Kaye

Bryan

et al. 2016

MMWR Surveill. Summ.

120

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“…This leads to progressive paralysis with a fatal outcome within an average of 3 years after diagnosis of the disease. (Couratier, et al 2016) Overall, there is no method that can measure the exact number of motor units. Nerve conduction studies and electromyography cannot provide accurate information about the number of motor unit loss.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility, and sensitivity to motor unit loss in amyotrophic lateral sclerosis, of a novel MUNE method: MScanFit MUNE

Bostock

Fuglsang‐Frederiksen

Duez

et al. 2017

Clinical Neurophysiology

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Highlights:-MScan is a novel promising MUNE method with good reproducibility and clinical potential.-MScan and MPS are better at discriminating between ALS patients and healthy controls than MUNIX.-Only MScan manages to distinguish patients with less certainty of ALS from healthy controls. AbstractObjective: To examine inter-and intra-rater reproducibility and sensitivity to motor unit loss of a novel motor unit number estimation (MUNE) method, MScanFit MUNE (MScan), compared to two traditional MUNE methods; Multiple point stimulation MUNE (MPS) and Motor Unit Number Index (MUNIX).Methods: Twenty-two ALS patients and 20 sex-and age-matched healthy controls were included.MPS, MUNIX, and MScan were performed twice each by two blinded physicians. Reproducibility of MUNE values was assessed by coefficient of variation (CV) and intra class correlation coefficient (ICC). Ability to detect motor unit loss was assessed by ROC curves and area under the curve (AUC). The times taken for each of the methods were recorded. Results:MScan was more reproducible than MPS and MUNIX both between and within operators.The mean CV for MScan (12.3%) was significantly lower than for MPS (24.7%) or MUNIX (21.5%). All methods had ICC>0.94. MScan and Munix were significantly quicker to perform than MPS (6.3m vs. 13.2m). MScan (AUC= 0.930) and MPS (AUC=0.899) were significantly better at discriminating between patients and healthy controls than MUNIX (AUC=0.831). Conclusions:MScan was more consistent than MPS or MUNIX and better at distinguishing ALS patients from healthy subjects.Significance: MScan may improve detection and assessment of motor unit loss.

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“…The disorders vary depending on the part of the SN (nervous system) affected. Often, the lack of strength is the first symptom that can manifest itself with fatigue, weakness of the upper or lower extremities, dysarthria and dysphagia (1). The Amyotrophic Lateral Sclerosis frequently affects males and usually occurs between 50 and 60 years.…”

Section: Introductionmentioning

confidence: 99%

“…There is no specific treatment, but a whole series of measures to improve these patients' quality of life: riluzole is the treatment better able to slow the progression, symptomatic therapies for the treatment of drooling, the cramps, pain, insomnia, principals and aids to encourage the remaining time. Not least is to be considered the psychological impact of the disease not only for patients but also for their families (1). The etiology and pathogenesis of Amyotrophic Lateral Sclerosis are currently largely unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Although some neurotoxic effects have been known for a long time, their role in neurodegeneration and in neurodegenerative diseases was understood recently. Studies in literature on the relationship between occupational and environmental exposures, and Amyotrophic Lateral Sclerosis are various and range from clinical or occupational case reports to case control studies, retrospective cohort studies and prospective, based on clinical data and death certificates and do not allow at the moment definitive conclusions (1,8,9). Exposure to pesticides has been assessed in several case-control studies (10)(11)(12)(13)(14)(15)(16) and in a cohort study (17); the exposure is generally associated with an increased risk in case-control studies, although the relationship was not always statistically significant.…”

Section: Introductionmentioning

confidence: 99%

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Occupational physician and amyotrophic lateral sclerosis: needs and training and information tools

Tomei¹

2017

PER

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Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease. The etiology and pathogenesis of ALS are currently largely unknown and the correlation between occupational and environmental exposures and ALS is not clear. The aim of this article is to create an information/training tools not only for workers but also for employers and occupational physicians. Materials and methods: within the project "Amyotrophic Lateral Sclerosis: contributory causes of occupational origin, risk assessment, early diagnosis and information-education" funded by IN-AIL, starting from the first year of the research, in parallel with the acquisition of the literature related to the research performed on Amyotrophic Lateral Sclerosis, contributing factors regarding work origin, it was decided to search for informative-educational material produced by the main international agencies and the main associations national and international patients members of the International Alliance ALS/MND Associations. All work tools are designed using the power point without animations for argument gravity. Results: brochures for occupational physician, employers and workers are created in order to understand the problems of the person with ALS and to maximize the potential workforce. Discussion: occupational physicians have to know all aspects of ALS in order to improve make a judgment of suitability appropriate for the employee/patient. Employers must know the aspects of the disease, especially from the organizational point of view in order to be prepared in this situation. Workers, intended as patients, have to know the disease and know how to deal with it in all possible situations. The psychological aspect has great importance and affects anyone who happens to live new and difficult situations such as ALS.

show abstract

Epidemiology of amyotrophic lateral sclerosis: A review of literature

Cited by 105 publications

References 74 publications

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013

Reproducibility, and sensitivity to motor unit loss in amyotrophic lateral sclerosis, of a novel MUNE method: MScanFit MUNE

Occupational physician and amyotrophic lateral sclerosis: needs and training and information tools

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