Epidemiology of ALS in Padova district, Italy, from 1992 to 2005

Cima, Valentina; Logroscino, Giancarlo; D’Ascenzo, Carla; Palmieri, Arianna; Volpe, M; Briani, Chiara; Pegoraro, Elena; Angelini, C.; Sorarù, Gianni

doi:10.1111/j.1468-1331.2009.02623.x

Cited by 26 publications

(23 citation statements)

References 28 publications

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“…With respect to age, the majority of studies report a greater number of patients in the 50-70 year agegroup, frequency ranging from 53.4% [18] to 68.1% [19]. The present study in which 148 patients (65.2%) were over 50 years of age is in agreement with those reports.…”

Section: Discussionsupporting

confidence: 94%

“…It is important to add that the mean age at onset of the disease in the patients in the present study (53.6± 12.1 years) is comparable with that of 60 ± 14 years reported by Larrodé-Pellicer et al [20] in your study in Zaragoza (Spain) and the study published by Cima et al [19] in Padova (Italy), in which mean age at onset was 64.8 ± 9.6 years.…”

Section: Discussionsupporting

confidence: 90%

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Clinical aspects of amyotrophic lateral sclerosis in Rio de Janeiro/Brazil

Loureiro¹,

Gress²,

Thuler³

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 90%

Clinical aspects of amyotrophic lateral sclerosis in Rio de Janeiro/Brazil

Loureiro¹,

Gress²,

Thuler³

et al. 2012

Journal of the Neurological Sciences

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“…Most studies, however, were conducted using 5-year [14, 29, 30, 43, 47, 48] or 10-year intervals [16, 19, 20, 32, 39, 42, 44]. The most frequently used data collection method was medical records review (n = 16) [13, 19, 22, 31–34, 37–40, 42, 44–46, 48], followed by ALS registries (n = 11) [14, 16–18, 20, 21, 23, 27, 30, 35, 49], surveys (n = 5) [15, 17, 18, 21, 25, 27–30, 43, 45, 47], and databases (n = 5) [24, 26, 36, 41, 47]. Most of the studies that used the medical records review approach were retrospective (81%); by contrast, most of the studies using ALS registries were prospective (70%).…”

Section: Resultsmentioning

confidence: 99%

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

et al. 2013

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Background: Amyotrophic lateral sclerosis (ALS) is relatively rare, yet the economic and social burden is substantial. Having accurate incidence and prevalence estimates would facilitate efficient allocation of healthcare resources. Objective: To provide a comprehensive and critical review of the epidemiological literature on ALS. Methods: MEDLINE and EMBASE (1995-2011) databases of population-based studies on ALS incidence and prevalence reporting quantitative data were analyzed. Data extracted included study location and time, design and data sources, case ascertainment methods and incidence and/or prevalence rates. Medians and interquartile ranges (IQRs) were calculated, and ALS case estimates were derived using 2010 population estimates. Results: In all, 37 articles met the inclusion criteria. In Europe, the median incidence rate (/100,000 population) was 2.08 (IQR 1.47-2.43), corresponding to an estimated 15,355 (10,852-17,938) cases. Median prevalence (/100,000 population) was 5.40 (IQR 4.06-7.89), or 39,863 (29,971-58,244) prevalent cases. Conclusions: Disparity in rates among ALS incidence and prevalence studies may be due to differences in study design or true variations in population demographics such as age and geography, including environmental factors and genetic predisposition. Additional large-scale studies that use standardized case ascertainment methods are needed to more accurately assess the true global burden of ALS.

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“…Chiò et al [5] found that the incidence of ALS reaches its maximum from 60 to 75 years of age. However, in the Cima study, this maximum occurs from 65 to 74 years of age [16], while in several studies in Nova Scotia, Canada, from 70 to 79 years old [17]. …”

Section: Introductionmentioning

confidence: 99%

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

et al. 2018

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Background: It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent. Our objective here was to investigate the association between long-term exposure to environmental factors and the occurrence of ALS in Catalonia, Spain, and to provide evidence that spatial clusters of ALS related to these environmental factors exist. Methods: We carried out a nested case-control study constructed from a retrospective population-based cohort, covering the entire region. Environmental variables were the explanatory variables of interest. We controlled for both observed and unobserved confounders. Results: We have found some spatial clusters of ALS. The results from the multivariate model suggest that these clusters could be related to some of the environmental variables, in particular agricultural chemicals. In addition, in high-risk clusters, besides corresponding to agricultural areas, key road infrastructures with a high density of traffic are also located. Conclusion: Our results indicate that some environmental factors, in particular those associated with exposure to pesticides and air pollutants as a result of urban traffic, could be associated with the occurrence of ALS.

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Epidemiology of ALS in Padova district, Italy, from 1992 to 2005

Abstract: This study confirmed an ALS incidence increase over the last 25 years in the Padova district. The increase in incidence may be partially explained by the ageing of the general population rather than by an improved diagnostic assessment.

Cited by 26 publications

References 28 publications

Clinical aspects of amyotrophic lateral sclerosis in Rio de Janeiro/Brazil

Clinical aspects of amyotrophic lateral sclerosis in Rio de Janeiro/Brazil

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study

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