Epidemiology of AIDS-related Kaposiʼs sarcoma in Europe over 10 years

Hermans, Philippe; Lundgren, Jens D; Sommereijns, Bernadette; Pedersen, Court; Vella, Stefano; Katlama, Christine; Lüthy, R; Pinching, Anthony J.; Gerstoft, Jan; Pehrson, P; Clumeck, Nathan

doi:10.1097/00002030-199607000-00015

Cited by 62 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with the survey by Hermans et al (1996), the highest percentages of KS at AIDS presentation were found in central Europe. This applies to homosexual as well as nonhomosexual men but has no clear explanation, as systematic surveys of KS-associated herpesvirus prevalence have not been performed in Europe.…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, in the same period, in several well-defined cohorts of HIV-infected individuals, the incidence of KS had remained approximately stable (Jacobson et al, 1990;Munioz et al, 1993;Montaner et al, 1994;Lundgren et al, 1995;Veugelers et al, 1995;Hermans et al, 1996). Conversely, declines in the cumulative incidence of KS from the early 1980s to the early 1990s were reported in two cohorts of AIDS patients from San Francisco, US (Katz et al, 1994), and Australia (Dore et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…It is at least partly attributed to the shorter latency period between HIV infection and KS onset than in other AIDS-defining illnesses (Hermans et al, 1996). According to some investigators (Elford et al, 1993;Dore et al, 1996), however, the relative decrease in KS might reflect a reduced prevalence and/or virulence of the postulated KS agent following the adoption of safer sexual practices by homosexual men.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Trends of Kaposi's sarcoma at AIDS diagnosis in Europe and the United States, 1987-94

Franceschi

Maso²,

Re³

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

Summary As a proportion of AIDS-defining illnesses, Kaposi's sarcoma (KS) decreased from 1987-89 to 1993-94 in homosexual and bisexual men in all European regions and in the United States. Albeit underestimated, AIDS KS rates in the general male population at ages 25-49 are higher than those of the majority of cancer sites in the same age group.Keywords: Kaposi's sarcoma; AIDS; incidence A steady decline, in terms of the percentage of Kaposi's sarcoma (KS) as an AIDS-defining illness, was first reported among homosexual and bisexual men in the United States (US) (Des Jarlais et al, 1987). The broadening of the definition of an AIDS case in 1987 does not entirely explain this decline, as it persists when analyses of trends are restricted to KS and Pneumocystis carinii (i.e. two conditions that have always been part of AIDS definition) (Beral et al, 1990).The relative decline in KS was confirmed in AIDS surveillance data or clinical series in several developed countries, such as the United Kingdom (UK) (Peters et al, 1991), Germany (Schwartlander et al, 1992), Italy (Serraino et al, 1992) and Australia (Elford et al, 1993). It is at least partly attributed to the shorter latency period between HIV infection and KS onset than in other AIDS-defining illnesses (Hermans et al, 1996). According to some investigators (Elford et al, 1993;Dore et al, 1996), however, the relative decrease in KS might reflect a reduced prevalence and/or virulence of the postulated KS agent following the adoption of safer sexual practices by homosexual men.Up to the end of 1994, approximately 440 000 AIDS cases had been recorded in official data in the US and about 140 000 in Europe. About 20% of AIDS patients had KS at the time of presentation. It is therefore possible to review systematically recent trends in KS in major European regions, and to assess separately non-homosexual men and women, groups that were little studied in the early phase of the epidemic on account of the low frequency of the disease. Finally, in order to quantify the minimum size of the epidemic of AIDS-associated KS at a population level, age-standardized incidence rates have been computed from AIDS surveillance data.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Trends of Kaposi's sarcoma at AIDS diagnosis in Europe and the United States, 1987-94

Franceschi

Maso²,

Re³

et al. 1997

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Likewise, in a cohort of Danish homosexual men, HHV-8 seropositivity correlated positively with the frequency of receptive anal intercourse 9 . Females infected with HIV by their bisexual male partners were found to be at greater risk of developing KS than those who became HIV-infected as a consequence of vaginal intercourse with male hemophiliacs, transfusion recipients, or injecting drug users 7,10 .…”

Section: Epidemiology Of Hhv-8 -Aspects Of Transmissionmentioning

confidence: 98%

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Leão¹,

Caterino–de–Araujo

Porter

et al. 2002

Rev. Hosp. Clin.

View full text Add to dashboard Cite

OBJECTIVE: To review the current literature on human herpesvirus 8 with particular attention to the aspects related to the etiopathogenesis of Kaposi's sarcoma. MATERIALS AND METHODS: The authors searched original research and review articles on specific aspects of human herpesvirus 8 infection, including virology, epidemiology, transmission, diagnosis, natural history, therapy, and Kaposi's sarcoma etiopathogenesis. The relevant material was evaluated and reviewed. RESULTS: Human herpesvirus 8 is a recently discovered DNA virus that is present throughout the world but with major geographic variation. In the Western world, the virus, transmitted mainly by means of sexual contact, is strongly associated with Kaposi's sarcoma and body cavity-based lymphoma and more controversially with multiple myeloma and other non-proliferative disorders. There is no specific effective treatment, but HIV protease inhibitors may play an indirect role in the clearance of human herpesvirus 8 DNA from peripheral blood mononuclear cells of HIV-infected patients. Human herpesvirus 8 DNA is present in saliva, but there are as yet no documented cases of nosocomial transmission to health care workers. The prevalence of human herpesvirus 8 among health care workers is probably similar to that in the general population. CONCLUSION: Human herpesvirus 8 appears to be, at least in Western Europe and United States, restricted to a population at risk of developing Kaposi's sarcoma. Human herpesvirus 8 certainly has the means to overcome cellular control and immune responses and thus predispose carriers to malignancy, particularly Kaposi's sarcoma. The wide diffusion of Human herpesvirus 8 in classic Kaposi's sarcoma areas appears to represent an important factor in the high incidence of the disease. However, additional co-factors are likely to play a role in the development of Kaposi's sarcoma.

show abstract

“…27 Other studies have found that CD 4ϩ count at the time of KS diagnosis tends to be higher and occurs before onset of other AIDS-defining events. 28 Therefore, there is more time to initiate HAART therapy before an advanced, irreversible stage of KS is reached. By delaying the progression of AIDS, thus suppressing viral-associated immune activation, KS progression will also be slowed.…”

Section: Cd4mentioning

confidence: 99%

Effect of highly active antiretroviral therapy on survival among HIV‐infected men with Kaposi sarcoma or non‐Hodgkin lymphoma

Tam

Zhang

Jacobson

et al. 2002

Intl Journal of Cancer

133

View full text Add to dashboard Cite

The effect of highly active antiretroviral therapy (HAART) on survival in HIV-infected patients with Kaposi sarcoma (KS) or non-Hodgkin lymphoma (NHL) is unknown. Our study examines survival after HAART for these 2 malignancies. Analyses were performed using data from 387 HIVinfected men in the Multicenter AIDS Cohort Study (MACS) after a diagnosis of either KS or NHL in 1990 -99. Potential prognostic factors, including HAART, were evaluated in univariate analyses using Kaplan-Meier survival curves and logrank tests. Multivariate survival analyses were conducted using Cox's time-dependent proportional hazards models, adjusting for CD4؉ cell levels at the time of cancer diagnosis and other covariates. Forty-three of 287 KS patients (15%) and 13 of 100 NHL patients (13%) had been treated with HAART. HAART treatment was associated with improved survival for KS and NHL patients (log-rank p ‫؍‬ 0.0001 for each group). In multivariate analyses, HAART was associated with an 81% reduced risk of death among KS patients [relative hazard (

show abstract

Epidemiology of AIDS-related Kaposiʼs sarcoma in Europe over 10 years

Cited by 62 publications

References 0 publications

Trends of Kaposi's sarcoma at AIDS diagnosis in Europe and the United States, 1987-94

Trends of Kaposi's sarcoma at AIDS diagnosis in Europe and the United States, 1987-94

Human herpesvirus 8 (HHV-8) and the etiopathogenesis of Kaposi's sarcoma

Effect of highly active antiretroviral therapy on survival among HIV‐infected men with Kaposi sarcoma or non‐Hodgkin lymphoma

Contact Info

Product

Resources

About