Epidemiology of Acute Viral Respiratory Tract Infections in Korean Children

Kim, Mi Ran; Lee, Hae Ran; Lee, Gyu Man

doi:10.1053/jinf.2000.0715

Cited by 54 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Respiratory symptoms were most frequent, followed by gastrointestinal symptoms, and this was comparable with previous data [222324]. In the present study, ADV caused more URTIs than LRTIs, even as the current literature provides contradictory evidences, with some reporting a predominance of URTIs [42526], whilst others report a predominance of LRTIs [2324]. …”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

et al. 2016

View full text Add to dashboard Cite

BackgroundAlthough adenovirus (ADV) infection occurs steadily all year round in Korea and the identification of respiratory viral coinfections has been increasing following the introduction of multiplex real-time polymerase chain reaction tests, the clinical impact of viral coinfection in children with ADV infection has rarely been reported.Materials and MethodsMedical records of children diagnosed with ADV infection were retrospectively reviewed. The enrolled children were divided into two groups based on the identified respiratory viruses: ADV group and coinfection group. Clinical and laboratory parameters were compared between the two groups.ResultsIn total, 105 children (60 males and 45 females) with a median age of 29 months (range: 0-131 months) diagnosed with an ADV infection were enrolled. Fever (99.0%) was by far the most frequent symptom, followed by respiratory (82.9%), and gastrointestinal (22.9%) symptoms. Upper and lower respiratory tract infections were diagnosed in 56 (53.3%), and 32 (30.5%) children, respectively. Five (4.8%) children received oxygen therapy, and no child died due to ADV infection. Coinfection was diagnosed in 32 (30.5%) children, with rhinovirus (46.9%), and respiratory syncytial virus (21.9%) being the most frequent. The proportions of children younger than 24 months (P <0.001), with underlying medical conditions (P = 0.020), and diagnosed with lower respiratory tract infection (P = 0.011) were significantly higher in the coinfection group than in the ADV group. In a multivariate analysis, only the younger age was significantly associated with coinfection (P <0.001). Although more children in the coinfection group received oxygen therapy (P = 0.029), the duration of fever and hospitalization was not significantly different between the two groups.ConclusionRespiratory viral coinfection with ADV occurred more frequently in children younger than 24 months of age compared with children aged 24 months or older. Respiratory viral coinfection may increase the severity of ADV infection, however, appropriate therapy prevented prolonged hospitalization and poor prognosis due to coinfection.

show abstract

Section: Discussionsupporting

confidence: 91%

“…Adenovirus (ADV) is one of the most common respiratory pathogens in childhood, and 13-17% of children hospitalized with a viral respiratory tract infection are diagnosed with an ADV infection [123]. Although most cases are self-limiting [34], ADV infection can lead to more severe complications and death.…”

Section: Introductionmentioning

confidence: 99%

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A few studies have identified an association between respiratory tract infection and relapse of IBD and have suggested that respiratory tract infection may predispose patients to exacerbation of IBD 30,31. In Korea, most respiratory tract viral infections show a seasonal pattern of occurrence with a peak in the spring and lower occurrence in autumn 32-34. This characteristic seasonal pattern of viral infection in Korea may suggest a link between viral infection and CD flares.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variation in Months of Birth and Symptom Flares in Korean Patients with Inflammatory Bowel Disease

Jung¹,

Song²,

Kim³

et al. 2013

Gut Liver

View full text Add to dashboard Cite

Background/AimsSeasonal variation may influence the development and exacerbation of inflammatory bowel disease (IBD). However, most epidemiologic studies on this topic have been conducted in Western countries. The purpose of this study was to determine whether birth dates and symptom flares follow a seasonal pattern in Korean patients with IBD.MethodsPatients with a diagnosis of IBD established between January 2003 and December 2010 were investigated at six university hospitals in Korea. The expected births and flares, with a uniform distribution during the year and considering differences in the number of days in the months of 1 year, were calculated.ResultsA total of 411 patients with ulcerative colitis (UC) and 316 patients with Crohn disease (CD) were included in the study. Birth during the winter period, and especially in January and February, was associated with an increased risk of IBD, especially in UC patients. The symptom flares of CD patients occurred most frequently in the spring, with a nadir in the autumn. However, no disease flare seasonality was noted for UC patients.ConclusionsOur data suggest that seasonally varying environmental factors during pregnancy and the postpartum period are associated with a susceptibility to IBD later in life and that exacerbations of CD are influenced by seasonal factors.

show abstract

“…Studies of CAP have traditionally focused little on viral causes[ 2 ]. Currently, viral infections are also involved with 80% of episodes of CAP in children under 2 years old and over 40% of older children [ 6 – 11 ]. The existing studies have showed that respiratory syncytial virus (RSV) and influenza viruses (Flu) are important pathogens among the hospitalized and outpatient children presenting with ARTI [ 5 , 6 ].Adenovirus virus (ADV) and parainfluenza viruses (PIV) are also associated with a substantial proportion of ALRI in infants and young children [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…With advances in methods aimed to detect pathogens, some pediatric patients with ALRT infections are infected simultaneously by multiple pathogens [ 10 , 11 ]. And it is suggested that co-infections are medically relevant, and effective treatment for severe respiratory tract infections ultimately requires diagnosis of all involved pathogens [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China

Liu

Xiong

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

Acute respiratory tract infections (ARTIs) are associated with significant morbidity and mortality worldwide, especially in children under the age of 5 years. Almost 2 million children die from ARTIs each year, and most of them are from developing countries. The prevalence and correlation of pathogens in ARTIs are poorly understood, but are critical for improving case prevention, treatment, and management. In this study, we investigated the prevalence and correlation of infectious agents in children with ARTIs. A total of 39,756 children with one or more symptoms, including fever, cough, sore throat, tonsillitis, pharyngitis, herpangina, pneumonia, and bronchiolitis, were enrolled in the study. All patients were hospitalized in Wuhan Children’s Hospital between October 1, 2010 and September 30, 2012, and were evaluated for infectious agents. Pathogens, including Mycoplasma pneumoniae, influenza A virus, influenza B virus, adenoviruses, respiratory syncytial virus, parainfluenza virus, Legionella pneumophila, Chlamydophila pneumoniae, and Coxiella burnetii, were screened simultaneously in patient blood samples using anti-pathogen IgM tests. Regression analysis was used to reveal correlations among the pathogens. Our results showed that one or more pathogens were identified in 10,206 patients, and that Mycoplasma pneumoniae, adenoviruses, and influenza B virus were the leading infectious agents. Mixed-infections of pathogens were detected in 2,391 cases, with Mycoplasma pneumoniae as the most frequent pathogen. The most common agents in the co-infections were Mycoplasma pneumoniae and influenza B virus. Regression analysis revealed a linear correlation between the proportion of mixed infections and the incidence of multi-pathogen infections. The prevalence of infectious agents in children with ARTIs was determined. Equations were established to estimate multiple infections by single-pathogen detection. This revealed a linear correlation for pathogens in children with ARTIs. This study provides useful information for improving case prevention and management.

show abstract

Epidemiology of Acute Viral Respiratory Tract Infections in Korean Children

Cited by 54 publications

References 16 publications

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Seasonal Variation in Months of Birth and Symptom Flares in Korean Patients with Inflammatory Bowel Disease

Prevalence and Correlation of Infectious Agents in Hospitalized Children with Acute Respiratory Tract Infections in Central China

Contact Info

Product

Resources

About