Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 1978–1982, compared to cases reported to the National Patient Register 1991–1993

Krogsgaard, Michael; Wagn, P.; Bengtsson, Jörgen

doi:10.3109/17453679808997789

Cited by 134 publications

(83 citation statements)

References 23 publications

(32 reference statements)

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“…The incidence of patients with spinal infection has been reported to have increased [2,3,7]. This is probably a result of an aging population, easy access to better diagnostic methods including MRI and an increase in the prevalence of immunocompromised hosts [2,17]. In this study, spinal infection had been decreasing until 1995; however, during the last ten years, it has been on the rise.…”

Section: Discussionmentioning

confidence: 55%

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Recent trends in spinal infections: retrospective analysis of patients treated during the past 50 years

Nagashima

Yamane

Nishi

et al. 2009

International Orthopaedics (SICOT)

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We retrospectively reviewed the medical charts of 210 consecutive patients treated for spinal infection in Tottori University Hospital in Japan between 1956 and 2005. Until 1995, spinal infection was under control in this series; however, during the last decade, it has been on the rise. Male predominance had been gradually progressing, and 69% of the patients were male during the last decade. Patients with spinal infection were aging, and the ratio of immunocompromised hosts dramatically increased to 53%. Until 1995, the percentage of patients with tuberculous spondylitis had been declining; however, the incidence has been on the rise during the last ten years. The organism was detected in 64% of patients treated between 1996 and 2005, of which Staphylococcus aureus was detected in 49%. Moreover, methicillin-resistant S. aureus was detected in 61% of patients with S. aureus. There were no immigrants or cases with human immunodeficiency virus in this series.

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Section: Discussionmentioning

confidence: 55%

“…Krogsgaard and colleagues [17] reported that male patients were dominant, 58% of the patients in 1991-1993, whereas the incidence was not significantly different between male and female patients in 1978-1982. Jacofsky and Currier [14] indicated that male predominance was due to the large number of intravenous drug abusers.…”

Section: Discussionmentioning

confidence: 99%

Recent trends in spinal infections: retrospective analysis of patients treated during the past 50 years

Nagashima

Yamane

Nishi

et al. 2009

International Orthopaedics (SICOT)

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“…Discussion SD is a rare but serious clinical condition that may lead to severe deformity and early or late neurological complications. A number of studies have reported a bimodal age distribution with peaks at age < 20 years and 50-70-years, though all ages can be affected [6][7][8]. SD has a male preponderance, with a male-to-female ratio of 1.5-2:1 [8][9][10].…”

Section: Resultsmentioning

confidence: 99%

Spondylodiscitis: evaluation of patients in a tertiary hospital

Kaya

Ercan

Kaya

et al. 2014

J Infect Dev Ctries

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Introduction: Spondylodiscitis (SD) is an uncommon but important infection. The aim of this work was to study the risk factors, bacteriological features, clinical, laboratory and radiological findings of SD, and to shed light on the initial treatment. Methodology: A total of 107 patients who underwent treatment for SD were evaluated. The diagnosis of SD was defined by clinical findings, complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum tube agglutination (STA) test, Ziehl-Neelsen staining, culture, histopathology, and radiological methods such as magnetic resonance imaging (MRI) and computed tomography (CT) scans. Results: Of the 107 cases, ranging between 17 to 83 years of age, 64 (59.8%) were male. Twenty-seven (25.2%) patients had diabetes mellitus. Laboratory investigations revealed elevated CRP in 70 (65%) patients, elevated ESR in 65 (61%) patients, and elevated white blood cell (WBC) counts in 41 (38.3%) patients. Thirty-six (33.6%) patients were identified as having brucellar SD, and 5 (4.7%) patients were identified as having tuberculous SD. A total of 66 (61.6%) patients were determined to have pyogenic SD. The most frequently isolated microorganism was Staphylococcus aureus. Antibiotic therapy was given intravenously to all pyogenic SD patients. Conclusions: The incidence of SD has increased as a result of the higher life expectancy of older patients with chronic debilitating diseases and the increase of spinal surgical procedures. In patients with low back pain, SD should be considered as a diagnosis. For effective treatment, it is important to determine the etiology of the disease.

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“…In 34-65% of all cases there is an increase of leukocytes (>11.5×10 9 ) and the rate of erythrocyte sedimentation rate (ESR) is 72-100%. Increased ESR over 70 mm/h is found in 72%, and more than 100 mm/h -in 17%.…”

Section: Laboratory Testsmentioning

confidence: 99%

“…[1][2][3]5,6 World literature reports of two peaks of the disease -in patients under 20 years and in the age range of 50-70 years. [6][7][8][9][10][11][12] In Europe, the disease varies from 0.4 to 2.4 cases per 100000, and the frequency depends on the inclusion criteria of the study (migrants, children, elderly, etc.). 4,7 SS is more common in men and the ratio of men to women is 2.1:1.5.…”

Section: Epidemiology Of Spontaneous Spondy-lodiscitismentioning

confidence: 99%

Spontaneous Spondylodiscitis - Epidemiology, Clinical Features, Diagnosis and Treatment

2017

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Spontaneous spondylodiscitis is a rare but serious infectious disease which is a combination of an inflammatory process, involving one or more adjacent vertebral bodies (spondylitis), the intervertebral discs (discitis) and finally - the neighboring neural structures. In most cases the condition is due to a hematogenous infection and can affect all regions of the spinal cord, but it is usually localized in the lumbar area. The most common clinical symptom is a pronounced, constant and increasing nocturnal paravertebral pain, while consequently different degrees of residual neurological symptoms from nerve roots and/or spinal cord may appear. The disease course is chronic and the lack of specific symptoms often prolongs the time between its debut and the diagnosis. This delay in diagnosis determines its potentially high morbidity and mortality. Treatment is conservative in cases with no residual neurological symptoms and consists of antibiotic therapy and immobilization. Surgical treatment is necessary in patients with neurological deficit, spinal instability or drug resistance.

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Epidemiology of acute vertebral osteomyelitis in Denmark: 137 cases in Denmark 1978–1982, compared to cases reported to the National Patient Register 1991–1993

Cited by 134 publications

References 23 publications

Recent trends in spinal infections: retrospective analysis of patients treated during the past 50 years

Recent trends in spinal infections: retrospective analysis of patients treated during the past 50 years

Spondylodiscitis: evaluation of patients in a tertiary hospital

Spontaneous Spondylodiscitis - Epidemiology, Clinical Features, Diagnosis and Treatment

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