2020
DOI: 10.1016/j.jiac.2020.05.022
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Epidemiology, molecular strain types, and macrolide resistance of Treponema pallidum in Japan, 2017–2018

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Cited by 5 publications
(5 citation statements)
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“…Second, all the macrolide-resistant strains in Japan in this study carried the A2058G mutation in the 23S rRNA gene, but not the A2059G mutation. This was in agreement with the results of our previous study of over 100 strains in Japan 17,18 .…”
Section: Discussionsupporting
confidence: 94%
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“…Second, all the macrolide-resistant strains in Japan in this study carried the A2058G mutation in the 23S rRNA gene, but not the A2059G mutation. This was in agreement with the results of our previous study of over 100 strains in Japan 17,18 .…”
Section: Discussionsupporting
confidence: 94%
“…The EAC was composed of SS14-lineage TPA strains in China and Japan, with most TPA strains in Japan (16/17) being subtype 14d/f, which is the dominant subtype among both heterosexual and MSM cases in Japan 17 . We could not evaluate the difference between subtype 14d/f strains from MSM and heterosexual cases in our previous molecular typing studies 17,18 . The WGS study in this report elucidated the separate phylogeny of the strains from MSM and heterosexuals belonging to this same subtype ( Table 1, and Fig.…”
Section: Discussionmentioning
confidence: 90%
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“…не было выделено ни одного азитромицинорезистентного изолята этого типа. В то же время связь между штаммами T. pallidum типа 14d/f и A2058Gассоциированной резистентно стью к макролидам выявлена в Южной Африке [24], Японии [30], Китае [31]. Данный факт подтверждает целесообразность изъятия антибиотиков группы ма кролидов как препаратов второй линии из российских клинических рекомендаций по лечению сифилиса по сле ряда публикаций о распространении резистентных к ним штаммов в различных географических регионах мира [32].…”
Section: Discussionunclassified
“…6,7 In China, high rates of A2058G mutation have been reported in Shanghai (95.4%), 8 Hunan (97.5%), 9 Shangdong (92.1%), 10 and Xiamen (100%), 11 whereas the A2059G mutation in the 23S rRNA gene of T. pallidum has only been reported in Shangdong, China, by Li et al 10 Taking swab samples from chancres was the most common method used to isolate T. pallidum for the detection of A2058G and A2059G point mutations in the 23S rRNA gene of T. pallidum in previous studies. [12][13][14] However, it is impossible to isolate T. pallidum from chancres in patients with latent syphilis, who have an absence of chancres and the other syphilis skin lesions. Several studies have reported using blood samples from syphilis patients to detect T. pallidum and macrolide resistance mutations in T. pallidum, although the detection rate of T. pallidum DNA is relatively low.…”
Section: Introductionmentioning
confidence: 99%