Epidemiology, molecular, and genetic methodologies to evaluate causes of CKDu around the world: report of the Working Group from the ISN International Consortium of Collaborators on CKDu

Anand, Shuchi; Caplin, Ben; González-Quiroz, Marvin; Schensul, Stephen L.; Bhalla, Vivek; Parada, Xavier Vela; Nanayakkara, Nishantha; Fire, Andrew; Levin, Adeera; Friedman, David J.; Aguilar-González, Angie; Abbot, Kevin; Abeysekara, Tilak; Amann, Kerstin; Ashuntantang, Gloria; Brooks, Daniel R.; Chavarria, Denis; Daniel, Christoph; Rotter, Ricardo Correa; Broe, Marc De; Silva, P. Mangala C.S. De; Domínguez, José; Eckardt, Kai‐Uwe; Fader, Dorien; Finkelstein, Fred; Fischer, R.; Ganguli, Anirban; Trabinho, Ramon Antonio Garcia; Glaser, Jason; Quiroz, Marvin Antonio Gonzalez; Haider, Lalarukh; Harris, D. Bruce; Herath, Chulani; Herrera, Raúl; Hradsky, Anne; Hoy, Wendy E.; Jakobsson, Kristina; Jayasinghe, Saroj; Jaysummana, Channa; Jha, Vivekanand; Johnson, Ross A.; Kambham, Neeraja; Karanasema, Nishamani; Kaze, François Folefack; Kimmel, Paul L.; Koritzinsky, Erik H.; Langham, Robyn G; Bellego, Laurent Le; Levin, N.; Lyuckx, Valerie; Madero, Magdalena; Martin, Ekiti; Malik, Charu; Moist, Louise; Moxey-Mims, Marva; Narva, Andrew S.; Nerbass, Fabiana Baggio; O’Donoghue, Dónal; Orantes, Carlos M.; Pearce, Neil; Ratnayake, Charaka; Roy-Chaudhury, Prabheer; Ruggiero, Agnese; Sánchez‐Lozada, Laura G.; Saran, Rajiv; Segantini, Luca; Seksek, Isabelle; Sheikh-Hamad, David; Star, Robert A.; Strani, Luisa; Vlahos, Penny; Wegman, David H.; Weiss, Ilana; Wijewickrama, Eranga; Wijkström, Julia; Wise, Paul H.; Wright, Elizabeth D.; Yang, Chih‐Wei; Yeates, Karen

doi:10.1016/j.kint.2019.09.019

Cited by 19 publications

(11 citation statements)

References 8 publications

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“…36 Recently, the International Society of Nephrology Working group accepted that a single GFR<60 mL/min/1.73 m 2 may be used to evaluate the risks of developing CKD in epidemiological studies, because the costs of repeating creatinine measurements are often too high to be practical. 37 As a sensitivity analysis, we also evaluated the risk of SES factors on incident CKD in which GFR<60 mL/min/1.73 m 2 was confirmed by a repeat measurement 5 years later. Although this analysis likely underestimated true CKD, we confirmed that education was an independent risk for iCKD5Y.…”

Section: Discussionmentioning

confidence: 99%

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Kitiyakara

Saranburut²,

Thongmung

et al. 2020

J Epidemiol Community Health

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BackgroundThere is limited information on the role of low socioeconomic status (SES) in the development of new chronic kidney disease (CKD) in the general population, especially from developing countries. This study will test the hypothesis that low SES increases the risk of incidence of decreased glomerular filtration rate (GFR, used as an estimate for CKD) in a Thai worker cohort.MethodIn this prospective, longitudinal observational study, we evaluated the association of income and educational attainment on incident decreased GFR (iGFR <60 mL/min/1.73 m2) over a 27-year period in employees of Electricity Generating Authority of Thailand. In 1985, subjects participated in a health survey and were re-examined in 1997, 2002, 2007 and 2012. Education was classified into three categories: low, 0–8th grade; medium, 9–12th grade; and high, >12th grade. Income was categorised as follows: low <10 000 Thai Baht (THB)/month; medium, 10 000–20 000 THB/month; and high, >20 000 THB/month. HRs of iGFR<60 mL/min/1.73 m2 were estimated using Cox interval-censored models with high income or education as the reference groups after adjustments for clinical risk factors.ResultsParticipants (n=3334) were followed for 23 (15, 27) years. When evaluated separately, both education and income were risk factors for iGFR<60 mL/min/1.73 m2 (adjusted HR education: medium—1.26 (95% CI 1.13 to1.42) and low—1.57 (95% CI 1.36 to 1.81) and adjusted HR income: medium—1.21 (95% CI 0.97 to 1.50) and low—1.47 (95% CI 1.18 to 1.82)). When both income and education were included together, low and medium education remained independently associated with iGFR<60 mL/min/1.73 m2.ConclusionsLow education was independently associated with increased risk of decreased GFR in a Thai worker population. Strategies to identify risk factors among low SES may be useful to prevent early CKD.

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Section: Discussionmentioning

confidence: 99%

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Kitiyakara

Saranburut²,

Thongmung

et al. 2020

J Epidemiol Community Health

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“…An emerging challenge relevant to these primary preventive efforts is the rise of a new form of CKD that is of “unknown etiology” and is, hence, referred to as “CKDu,” which has resulted in substantial morbidity and mortality including certain regions of the world with heavy agricultural occupation such as Nicaragua and Sri Lanka (Anand et al 2019). There are currently concerted efforts by the international nephrology community to identify the potential modifiable and nonmodifiable risk factors of CKDu, and to develop potential interventions to mitigate the burden of this emerging disease state.…”

Section: Primary Prevention Of Ckdmentioning

confidence: 99%

Kidney Health for Everyone Everywhere—From Prevention to Detection and Equitable Access to Care

Garcia-Garcia

Lui

et al. 2020

Journal of Renal Care

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6Figure 1: Overview of the preventive measures in chronic kidney disease (CKD) to highlight the similarities and distinctions pertaining to primary, secondary, and tertiary preventive measures and their intended goals. AKI, acute kidney injury; BP, blood pressure; GFR, glomerular filtration rate; RAASi, renin-angiotensin-aldosterone system inhibitors; SGLT2i, sodium-glucose cotransporter-2 inhibitors.Li et al.

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“…12 An emerging challenge relevant to these primary preventive efforts is the rise of a new form of CKD that is of "unknown etiology" and is, hence, referred to as "CKDu," which has resulted in substantial morbidity and mortality including in certain regions of the world with heavy agricultural occupation such as Nicaragua and Sri Lanka. 15 There are currently concerted efforts by the international nephrology community to identify the potential modifiable and nonmodifiable risk factors of CKDu, and to develop potential interventions to mitigate the burden of this emerging disease state. Many of these risk factors contribute to both de novo CKD and its faster progression and hence are relevant to both primary and secondary prevention.…”

Section: Primary Prevention Of Ckdmentioning

confidence: 99%

Kidney Health for Everyone Everywhere—From Prevention to Detection and Equitable Access to Care

Garcia-Garcia

Lui

et al. 2020

Kidney International Reports

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This article is being published in Kidney International Reports and reprinted concurrently in several journals. The articles cover identical concepts and wording, but vary in minor stylistic and spelling changes, detail, and length of manuscript in keeping with each journal's style. Any of these versions may be used in citing this article. Note that all authors contributed equally to the conception, preparation, and editing of the manuscript. 11 Members of the World Kidney Day Steering Committee are listed in the Appendix.

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Epidemiology, molecular, and genetic methodologies to evaluate causes of CKDu around the world: report of the Working Group from the ISN International Consortium of Collaborators on CKDu

Cited by 19 publications

References 8 publications

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Long-term effects of socioeconomic status on the incidence of decreased glomerular filtration rate in a Southeast Asian cohort

Kidney Health for Everyone Everywhere—From Prevention to Detection and Equitable Access to Care

Kidney Health for Everyone Everywhere—From Prevention to Detection and Equitable Access to Care

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