Epidemiology, Microbiology, and Genetics of Contact Lens–Related and Non–Contact Lens-Related Infectious Keratitis

Stapleton, Fiona; Vijay, Ajay Kumar; Carnt, Nicole

doi:10.1097/icl.0000000000000884

Cited by 21 publications

(13 citation statements)

References 74 publications

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“…Previous studies have found that staphylococci and Pseudomonas aeruginosa were the most prevalent microorganisms found in post-traumatic IK. 12 As shown in Figure 4, the anti-bacterial spectrum of aminoglycosides and quinolones is almost similar, except that aminoglycosides are often effective against methicillinresistant staphylococci while quinolones are not. 13 Conversely, quinolones are effective against chlamydia while aminoglycosides are not.…”

Section: Discussionmentioning

confidence: 94%

Corneal foreign bodies: are antiseptics and antibiotics equally effective?

Rebattu

Baillif

Ferrete

et al. 2023

Eye

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To compare the effect of antiseptics and antibiotics on the occurrence of Infectious Keratitis (IK) secondary to Corneal Foreign Body (CFB) removal. MethodsMulticenter retrospective study conducted between June 2020 and June 2022 in patients referred for CFBs and treated with Picloxydine (Group 1) or Tobramycin (Group 2) for 7 days. A follow-up visit was scheduled on Day 3 (D3) and a phone call on D30. The primary outcome measure was the occurrence of IK. Results307 patients (300 men) with a mean age of 42.8 (14.8) years were included. The mean (SD) time to consultation was 43.1 (45.6) hours. Picloxydine and Tobramycin were given to 155 and 152 patients. Half of patients (n = 154, 50.2%) were building workers and 209 (68.1%) did not wear eye protections. CFBs were mainly metallic (n = 292, 95.1%). Upon referral, rust was found in 220 patients (72.1%). A burr was used in 119 (38.9%) patients. IK occurred in 15 (4.9%) patients, 8 (5.3%) in Group 1 and 7 (4.5%) in Group 2 (p = 0.797). IK was successfully treated in all cases. Persistent rust was found in 113 patients (36.9%) on D3 without difference between burr or needle use (p = 0.278). On D3, corneal healing was delayed in 154 patients (47.2%), mainly in burr-treated patients (p = 0.003). The mean (SD) work stoppage duration was 0.32 (0.98) days. ConclusionIK rate was 4.9%. The e cacy of antibiotics and antiseptics was similar on CFB removal. Using a burr was associated with a longer healing time. CFBs had a limited social impact.

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Section: Discussionmentioning

confidence: 94%

Corneal foreign bodies: are antiseptics and antibiotics equally effective?

Rebattu

Baillif

Ferrete

et al. 2023

Eye

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“…Noszenie soczewek kontaktowych jest istotnym czynnikiem, predysponującym do infekcyjnego zapalenia rogówki w krajach rozwiniętych. Stanowi przyczynę aż 45-66% nowo rozpoznawanych przypadków, i jednocześnie aż 20-23 % ciężkich przypadków zapalenia rogówki wymagających hospitalizacji [14,15]. Drobnoustroje izolowane najczęściej od pacjentów używających szkła kontaktowe to Pseudomonas aeruginosa i Acanthamoeba spp.…”

Section: Używanie Soczewek Kontaktowych I Ortokorekcyjnychunclassified

“…Zakażenie częściej rozwija się u osób, które nie ściągają szkieł na czas nocnego odpoczynku, nie myją rąk przed ich założeniem, nie dbają o czystość pojemników do przechowywania soczewek i używają wielofunkcyjnego płynu do ich pielęgnacji, który rzadko wymieniają. Jakikolwiek kontakt oka z wodą wodociągową lub ze zbiornika wodnego skażonego Acanthamoeba grozi rozwojem pierwotniakowego zakażenia rogówki [14]. Soczewki roczne stanowią większe ryzyko infekcji, w porównaniu z miesięcznymi czy dwutygodniowymi [16].…”

Section: Używanie Soczewek Kontaktowych I Ortokorekcyjnychunclassified

Risk factors for infectious keratitis - a literature review

Sereda

Nieścior

Metelska

et al. 2022

J Educ Health Sport

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Introduction and purpose Infectious keratitis represents the leading cause of corneal blindness worldwide, particularly in developing countries. Both risk factors and etiological patterns vary between economically developed and developing regions, with bacterial predominance in the former and fungal predominance in the latter. This review aims to provide an updated overview of the risk factors in relation to infectious keratitis. Description of the state of knowledge Infectious keratitis is a painful and potentially vision-threatening ophthalmic condition characterized by decreased vision, photophobia and eye redness. In severe cases, it may require hospital admission for intensive medical treatment or surgical interventions. It can be caused by a wide array of organisms, including bacteria, fungi, viruses, parasites or polymicrobial infection. The most commonly observed predisposing factors for infectious keratitis include contact lens wear, trauma, ocular surface diseases, post-corneal surgery and systemic or local immunosuppression. Manual workers in construction or agricultural industry, exposed to vegetative matter, organic materials and animal products are particularly at risk. Higher rate of incidence is also observed in regions with poor environmental and personal hygiene, low level of education, poor access to sanitation and healthcare facility. Summary Persistent prevalence of infectious keratitis in both developed and developing countries makes it a serious medical problem. Prevention, proper diagnosis and effective treatment are crucial for positive visual outcome.

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“…Even with this great diversity, the OS microbiota remains much less rich in comparison to those of the gut, skin, or oral cavity [ 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Healthy Eye Microbiota Niche in a Multicenter Study

Borroni

Paytuví-Gallart

Sanseverino

et al. 2022

IJMS

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Purpose: This study aims to explore and characterize healthy eye microbiota. Methods: Healthy subjects older than 18 years were selected for this descriptive cross-sectional study. Samples were collected with an eSwab with 1 mL of Liquid Amies Medium (Copan Brescia, Italy). Following DNA extraction, libraries preparation, and amplification, PCR products were purified and end-repaired for barcode ligation. Libraries were pooled to a final concentration of 26 pM. Template preparation was performed with Ion Chef according to Ion 510, Ion 520, and Ion 530 Kit-Chef protocol. Sequencing of the amplicon libraries was carried out on a 520 or 530 chip using the Ion Torrent S5 system (Thermo Fisher; Waltham, MA, USA). Raw reads were analyzed with GAIA (v 2.02). Results: Healthy eye microbiota is a low-diversity microbiome. The vast majority of the 137 analyzed samples were highly enriched with Staphylococcus, whereas only in a few of them, other genera such as Bacillus, Pseudomonas, and Corynebacterium predominate. We found an average of 88 genera with an average Shannon index of 0.65. Conclusion: We identified nine different ECSTs. A better understanding of healthy eye microbiota has the potential to improve disease diagnosis and personalized regimens to promote health.

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Epidemiology, Microbiology, and Genetics of Contact Lens–Related and Non–Contact Lens-Related Infectious Keratitis

Cited by 21 publications

References 74 publications

Corneal foreign bodies: are antiseptics and antibiotics equally effective?

Corneal foreign bodies: are antiseptics and antibiotics equally effective?

Risk factors for infectious keratitis - a literature review

Exploring the Healthy Eye Microbiota Niche in a Multicenter Study

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