Epidemiology, management and risk of SARS-CoV-2 transmission in a cohort of newborns born to mothers diagnosed with COVID-19 infection

Solís-García, Gonzalo; Gutiérrez‐Vélez, Ana; Chamorro, Isabel Pescador; Zamora-Flores, Elena; Vigil‐Vázquez, Sara; Rodríguez-Corrales, Elena; Sánchez‐Luna, Manuel

doi:10.1016/j.anpede.2020.12.006

Cited by 15 publications

(22 citation statements)

References 24 publications

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“…Of the latter, 160 were selected for full-text review, but only 72 studies fulfilled the selection criteria ( Figure 1 ). Of the 72 full-text articles included, 62 were case reports or case series, nine were cohort studies ( 13 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ), and one was a cross-sectional study ( 29 ). In the 72 studies, 1,246 newborns were reported; however, 1,010 patients were excluded because 630 were born to COVID-19-positive mothers but had a negative RT–PCR test, 308 were infants, 69 underwent RT–PCR tests, and three newborns had only positive SARS-CoV-2 antibodies.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, this systematic review comprised data from 236 newborns. Table S1 summarizes the data of the 72 included studies ( 13 , 14 , 15 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , ...…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

COVID-19 in Neonates with Positive RT–PCR Test. Systematic Review

García

Allende-López

Morales-Ruíz

et al. 2022

Archives of Medical Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

COVID-19 in Neonates with Positive RT–PCR Test. Systematic Review

García

Allende-López

Morales-Ruíz

et al. 2022

Archives of Medical Research

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“…[18][19][20] A cohort study conducted in the United States by Salvatore et al that included 116 mothers found no cases of perinatal transmission and a meta-analysis by Kotlyar et al that includes some of these data reported a frequency of potential vertical transmission of 2.7%, similar to the frequency observed by Dumitriu et al in a cohort study conducted in New York, although it is likely that some of these infections resulted from horizontal transmission. [21][22][23][24] The virus is not secreted in breast milk and appropriate measures like wearing mask and frequent hand washing should be taken when mother is breast feeding.…”

Section: Maternal Deathsmentioning

confidence: 99%

COVID-19 among pregnant women: management outcome and risk of transmission to newborns in western India

Monga

Sardana²,

Sen

et al. 2021

Int J Community Med Public Health

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Background: The WHO declared a global pandemic of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 in March 2020. With so much female population in reproductive period in India the effect of corona virus in pregnancy warrants attention as the impact of maternal infection during pregnancy in India remains poorly understood. Objectives of current study were to know the management outcome and risk of transmission among COVI-19 positive pregnant women admitted in a tertiary care institute in western India.Materials: The present cross sectional study was conducted among 217 admitted COVID-19 positive pregnant women in a tertiary care institute in western India from May 2020 to April 2021. Data were collected from the department of obstetrics and gynaecology after taking permission from the head of department of obstetrics and gynaecology. Results: Most of patients were asymptomatic and managed conservatively but some also needed special interventions. Out of 217 patients 124 patients delivered in the hospital, 5 maternal deaths, one stillbirth and one congenital anomaly was reported. Only 25% of patients had normal delivery rest had caesarean and one neonate was found COVID-19 positive. Around one forth deliveries were pre term.Conclusions: The study suggests that most women do not have severe illness and that transmission of infection to infants of infected mothers is uncommon but there are increased chances of pre-term delivery. Majority of the women and neonates were managed and discharged without any major complications. But in some cases COVID in pregnancy may complicate the situation; so it should be handled by a multidisciplinary team of experts in COVID-19.

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“…Diferentes autores han sugerido la posibilidad de transmisión intraútero, pero no está claro si esta ocurre vía transplacentaria, a través del canal del parto o en el periodo posnatal inmediato 1 . Se han publicado casos aislados, series de casos 2 , 3 y recomendaciones de expertos de las distintas sociedades científicas 4 , 5 , con resultados muy heterogéneos en cuanto a la definición de transmisión vertical, muestras biológicas estudiadas y manifestaciones clínicas en el neonato.…”

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“…La transmisión vertical de SARS-CoV-2 es aún poco conocida. Aunque se ha documentado la presencia del virus en la placenta, el líquido amniótico, la sangre de cordón y la leche materna ocasionalmente 6 , la mayoría de los test diagnósticos realizados a los recién nacidos de madres infectadas son negativos 3 y, por lo tanto, poco concluyentes para establecer el diagnóstico de infección vertical.…”

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