Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings

Ulrickson, Matthew L.; Press, Oliver W.; Casper, Corey

doi:10.1155/2012/932658

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…CD4 count, carried out for 22 cases out of 54, showed no difference in the depth of immunosuppression that cancer is either AIDS defining or not. For defining AIDS cancers, there is no doubt that the risk is higher in the case of lower CD4 count (<200 cells/mL) [ 24 , 25 ]. However, there are controversies with regard to the depth of immunosuppression in nondefining AIDS cancer [ 22 , 23 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea)

Traoré

Bah

Traore

et al. 2015

Journal of Cancer Epidemiology

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Aim. To determine the prevalence of HIV infection among patients seen at the surgical oncology unit of Donka (Conakry, Guinea). Method. We conducted a retrospective and descriptive study of HIV infection in cancer patients from May 2007 to December 2012. Social characteristics (age, gender, marital status, and education) and immune status (HIV type, CD4 count) were reviewed. Results. Out of 2598 cancer patients, 54 (2.1%) tested positive for HIV. There were 11 (20.4%) defining AIDS and 43 (79.6%) nondefining AIDS cancers. The most frequent cancers were breast (14) (26.0%), non-Hodgkin lymphoma (6) (11.1%), liver (6) (11.1%), eye and annexes (6) (11.1%), and cervical cancer (5) (9.3%). These patients were female in 34 (63.0%) and had a median age of 39 years and body mass index was 20,3 Kg/m2. They were unschooled in 40 (74.1%) and married in 35 (64.8%). CD4 count showed a median of 317 cells/mL. Antiretroviral treatment was performed in 40 (74.1%). Conclusion. HIV prevalence is higher in patients in our unit of surgical oncology. Breast cancer was the most common in this association. A national survey of a large sample is needed to determine the true prevalence and impact of HIV on cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea)

Traoré

Bah

Traore

et al. 2015

Journal of Cancer Epidemiology

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“…In the post HAART (highly active anti-retroviral therapy) era, non-Hodgkin lymphoma (NHL) is the most common malignancy in PWHA, superseding Kaposi's sarcoma. This is particularly true in resource-limited settings, such as sub-Saharan Africa, where there is a noticeable increase in NHL incidence [6]- [9]. HIV-NHL are typically highgrade, B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma [3] [9] [10].…”

Section: Lymphoma and Hivmentioning

confidence: 99%

The Impact of Human Immunodeficiency Virus Infection (HIV) on Lymphoma in South Africa

Patel¹,

Philip²,

Touzani³

et al. 2015

JCT

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“…Use of the DA-EPOCH regimen has been suggested as unreasonable in low resource settings [16] possibly due to lack of infrastructure and supportive medications in addition to the demands of the 24 h continuous infusion of this regimen. Uganda Cancer Institute (UCI) has in the recent past embarked on the use of DA-EPOCH regimen in a selected group of patients with HIV associated NHL.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of treatment with CHOP and EPOCH in patients with HIV associated NHL in a low resource setting

et al. 2020

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Background: The optimal chemotherapy regimen for treating HIV associated NHL in low resource settings is unknown. We conducted a retrospective study to describe survival rates, treatment response rates and adverse events in patients with HIV associated NHL treated with CHOP and dose adjusted-EPOCH regimens at the Uganda Cancer Institute. Methods: A retrospective study of patients diagnosed with HIV and lymphoma and treated at the Uganda Cancer Institute from 2016 to 2018 was done. Results: One hundred eight patients treated with CHOP and 12 patients treated with DA-EPOCH were analysed. Patients completing 6 or more cycles of chemotherapy were 51 (47%) in the CHOP group and 8 (67%) in the DA-EPOCH group. One year overall survival (OS) rate in patients treated with CHOP was 54.5% (95% CI, 42.8-64.8) and 80.2% (95% CI, 40.3-94.8) in those treated with DA-EPOCH. Factors associated with favourable survival were BMI 18.5-24.9 kg/m 2 , (p = 0.03) and completion of 6 or more cycles of chemotherapy, (p < 0.001). The overall response rate was 40% in the CHOP group and 59% in the DA-EPOCH group. Severe adverse events occurred in 19 (18%) patients in the CHOP group and 3 (25%) in the DA-EPOCH group; these were neutropenia (CHOP = 13, 12%; DA-EPOCH = 2, 17%), anaemia (CHOP = 12, 12%; DA-EPOCH = 1, 8%), thrombocytopenia (CHOP = 7, 6%; DA-EPOCH = 0), sepsis (CHOP = 1), treatment related death (DA-EPOCH = 1) and hepatic encephalopathy (CHOP = 1). Conclusion: Treatment of HIV associated NHL with curative intent using CHOP and infusional DA-EPOCH is feasible in low resource settings and associated with > 50% 1 year survival.

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Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings

Cited by 12 publications

References 47 publications

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea)

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea)

The Impact of Human Immunodeficiency Virus Infection (HIV) on Lymphoma in South Africa

Outcomes of treatment with CHOP and EPOCH in patients with HIV associated NHL in a low resource setting

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