Epidemiology, Demographics and Natural History

Hartofilakidis, George; Babis, George C.; Lampropoulou-Adamidou, Kalliopi

doi:10.1007/978-88-470-5492-9_4

Cited by 27 publications

(32 citation statements)

References 15 publications

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“…DDH is a main cause of childhood disability and early onset hip osteoarthritis [3–5], and an epidemiologic study showed that DDH underlies up to 9% and 29% of all primary hip arthroplasty and those in people younger than 60 years, respectively [6]. DDH is affected by multiple factors including environmental and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population

Shi

Sun

et al. 2014

BioMed Research International

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Developmental dysplasia of the hip (DDH) is a common developmental hip disorder, which ranges from mild acetabulum malformation to irreducible hip dislocation. A previous study suggested a significant association of pregnancy-associated plasma protein-A2 (PAPPA2) with DDH susceptibility in Chinese Han population. But with the consideration of the sample size, the association was still debatable. To confirm the association of the reported single nucleotide polymorphism (SNP) in PAPPA2, rs726252 with DDH, we conducted a case-control study in a larger number of subjects. We genotyped rs726252 in 697 DDH subjects and 707 control subjects by TaqMan assay. The association between this SNP and DDH was evaluated statistically. No significant difference was found in any comparison of genotype distribution nor allele frequency between cases and controls. Our replication study indicated that the association between rs726252 and DDH in Chinese Han population was debatable. The association between PAPPA2 and DDH should be evaluated by additional studies.

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Section: Introductionmentioning

confidence: 99%

A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population

Shi

Sun

et al. 2014

BioMed Research International

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“…One study demonstrated a higher prevalence of abnormal hip morphology and OA among Caucasian compared with Asian women 12 . Gender differences have also been explored, with hip dysplasia much more common among women 18, 19 , and a greater tendency toward cam-type morphology (higher mean radiographic anteroposterior [AP] alpha angle, triangular index sign) in men 20, 21 . Despite research among these and other populations, no research has been conducted to assess FAI and variations in hip morphology among African Americans (AA) and very few studies have utilized a community-based sample.…”

mentioning

confidence: 99%

Measures of hip morphology are related to development of worsening radiographic hip osteoarthritis over 6 to 13 year follow-up: the Johnston County Osteoarthritis Project

Nelson

Stiller

Shi

et al. 2016

Osteoarthritis and Cartilage

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Objectives We sought to describe the effect of alterations in hip morphology with respect to worsening hip OA in a community-based sample including African American (AA) and white men and women. Methods This nested case-control study defined case hips as Kellgren Lawrence grade (KLG)<3 on baseline supine pelvis radiographs and KLG≥3 or THR for OA at the 1st or 2nd follow-up visit (mean 6 and 13 years, respectively); control hips had KLG<3 at both visits, with gender/race distribution similar to cases. Hip morphology was assessed using HipMorf software (Oxford, UK). Descriptive means and standard errors were obtained from generalized estimating equation (GEE) models. Sex-stratified GEE regression models (accounting for within-person correlation), adjusted for age, race, BMI, and side were then employed. Results A total of 120 individuals (239 hips; 71 case/168 control) were included (25% male, 26% AA, mean age 62 years, BMI 30 kg/m2). Case hips tended to have greater baseline AP alpha angles, smaller minimum joint space width (mJSW) and more frequent triangular index signs. Adjusted results among men revealed that higher AP alpha angle, Gosvig ratio, and acetabular index were positively associated with case hips; coxa profunda was negatively associated. Among women, greater AP alpha angle, smaller mJSW, protrusio acetabuli, and triangular index sign were associated with case hips. Conclusions We confirmed an increased risk of worsening hip OA due to baseline features of cam deformity among men and women, as well as protrusio acetabuli among women, and provide the first estimates of these measures in AAs.

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“…Ultimately, these studies will provide an answer concerning the efficiency of delaying or preventing osteoarthritis when compared to published studies about the natural course of osteoarthritis in DDH [5,7]. Multicenter studies might speed up this process since a larger number of patients could be gathered in a shorter period of time.…”

Section: How Do We Get There?mentioning

confidence: 99%

“…The treatment goal is to obtain a durably pain-free and functional hip. It remains unclear whether surgery can delay or prevent early osteoarthritis [5,7,10,11] and if so in which patients.…”

mentioning

confidence: 99%

Report of Breakout Session: Defining Parameters for Correcting the Acetabulum During a Pelvic Reorientation Osteotomy

Millis

Siebenrock

Participants

2012

Clinical Orthopaedics &Amp; Related Research

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Epidemiology, Demographics and Natural History

Cited by 27 publications

References 15 publications

A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population

A Replication Study for the Association of rs726252 in PAPPA2 with Developmental Dysplasia of the Hip in Chinese Han Population

Measures of hip morphology are related to development of worsening radiographic hip osteoarthritis over 6 to 13 year follow-up: the Johnston County Osteoarthritis Project

Report of Breakout Session: Defining Parameters for Correcting the Acetabulum During a Pelvic Reorientation Osteotomy

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