Epidemiology, Clinical Data, and Treatment of Viral Hepatitis in a Large Cohort of Intravenous Drug Users

Gigi, Eleni; Sinakos, Emmanouil; Sykja, Albana; Androulakis, G; Tanis, Christos; Stayridou, Victoria; Tsirogianni, E.; Zouridakis, Konstantinos; Bellou, Aristea-Lia; Raptopoulou‐Gigi, M.

doi:10.1097/adm.0b013e318279756f

Cited by 15 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most prevalent HCV genotype in this study was genotype Type III. In recent studies done in Iran, the most prevalent genotype, was Type III[34] and studies in other countries including, Saudi Arabia revealed genotype IV as the most prevalent,[567] genotype Type II in Chinese and Brazilian prisoners,[89] Type II in Greek IVDUs[10] and Type I in other Countries. [11112]…”

Section: Discussionmentioning

confidence: 99%

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

2017

View full text Add to dashboard Cite

Background:Hepatitis C infection is one of the health problems in the world. Several known risk factors are responsible in transmission of this infection. We are going to study the prevalence of these risk factors for different genotypes of hepatitis C and if possible, specify probable relations between each risk factor and transmission of each genotype.Materials and Methods:This is a cross-sectional study done on 270 people who had positive anti-hepatitis C virus (HCV) antibody and HCV RNA. Demographic specificity and possible risk factors were collected using a questionnaire, and statistical analysis was done by SPSS software (version 20). Chi-square test used to estimate the prevalence and relation between each qualitative risk factor and HCV genotype transmitted. Analysis of variance was used for studying the prevalence and relation between quantitative risk factors and HCV genotypes.Results:The sample size was 270 persons. Of these, 217 (80.4%) were men and 185 (68.5%) were infected with genotype Type III. Most people were in age range of 31–40 years old 92 (34%). Single people were 126 (46.7%) and 169 (62.6%) were high school and university graduated. Tattooing as a risk factor had a meaningful relation with hepatitis C genotype (P < 0.001).Conclusions:According to the findings, most people in central provinces of Iran with hepatitis C are carrying genotype III, with most prevalent risk factors such as intravenous drug use and unsafe sexual activity. Besides, tattooing had a significant association with hepatitis C genotype, so that in these groups of people, genotype I was more frequent isolated virus.

show abstract

Section: Discussionmentioning

confidence: 99%

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

2017

View full text Add to dashboard Cite

show abstract

“…After treatment was made available in the OST clinic 85 patients (25%) commenced therapy [ 24 ]. Gigi et al demonstrated higher rates of treatment uptake in an OST clinic compared to a tertiary hospital clinic (61% vs 55%) [ 25 ]. To our knowledge, the only randomised trial regarding the impact of placement of HCV treatment services in OST clinics on treatment uptake was conducted by Bruce et al, and included modified directly observed therapy [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

The Cascade of Care for an Australian Community-Based Hepatitis C Treatment Service

et al. 2015

View full text Add to dashboard Cite

BackgroundHepatitis C treatment uptake in Australia is low. To increase access to hepatitis C virus treatment for people who inject drugs, we developed a community-based, nurse-led service that linked a viral hepatitis service in a tertiary hospital to primary care clinics, and resulted in hepatitis C treatment provision in the community.MethodsA retrospective cohort study of patients referred to the community hepatitis service was undertaken to determine the cascade of care. Logistic regression analyses were used to identify predictors of hepatitis C treatment uptake.ResultsFour hundred and sixty-two patients were referred to the community hepatitis service; 344 attended. Among the 279 attendees with confirmed chronic hepatitis C, 257 (99%) reported ever injecting drugs, and 124 (48%) injected in the last month. Of 201 (72%) patients who had their fibrosis staged, 63 (31%) had F3-F4 fibrosis. Fifty-five patients commenced hepatitis C treatment; 26 (47%) were current injectors and 25 (45%) had F3-F4 fibrosis. Nineteen of the 27 (70%) genotype 1 patients and 14 of the 26 (54%) genotype 3 patients eligible for assessment achieved a sustained virologic response. Advanced fibrosis was a significant predictor of treatment uptake in adjusted analysis (AOR 2.56, CI 1.30–5.00, p = 0.006).ConclusionsOur community hepatitis service produced relatively high rates of fibrosis assessment, hepatitis C treatment uptake and cure, among people who inject drugs. These findings highlight the potential benefits of providing community-based hepatitis C care to people who inject drugs in Australia–benefits that should be realised as direct-acting antiviral agents become available.

show abstract

“…In overall pooled studies and in studies conducted in countries other than Egypt, the risk factor of strongest association was IDUs, followed by IDU partner, HIV and HBV infections. This holds true in pooled studies done in Egypt and reinforces the significance of this form exposure being the most important factor contributing to HCV spread . Nevertheless, the present results are at variance with a recent MA by Mahmoud et al ., 2013 who reported that the contribution of IDU to HCV prevalence is much lower in Egypt than in other countries where transmission is mainly associated with medical exposures .…”

Section: Discussionmentioning

confidence: 99%

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

El‐Ghitany

Wahab

El‐Wahab

et al. 2014

Liver International

View full text Add to dashboard Cite

show abstract

Epidemiology, Clinical Data, and Treatment of Viral Hepatitis in a Large Cohort of Intravenous Drug Users

Cited by 15 publications

References 15 publications

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

The Correlation between Different Risk Factors of Hepatitis C and Different Genotypes

The Cascade of Care for an Australian Community-Based Hepatitis C Treatment Service

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

Contact Info

Product

Resources

About