Epidemiology, Clinical Characteristics and Outcome of Acute Kidney Injury in Intensive Care Units of Alexandria University Hospitals

Abstract

Background: Acute kidney injury (AKI) considered as a major public health problem that affects millions of patients worldwide and leads to decreased survival and increased progression of chronic kidney disease (CKD).Aim of study: Epidemiology, clinical characteristics and outcome of acute kidney injury in patients admitted to main Alexandria university hospitals over six months. Methods:All patients who were admitted to intensive care units (ICUs) at Alexandria University Hospitals were prospectively studied. Patients who developed ICU-acquired acute renal failure were collected in the period over six months.Results: Our study included 500 patients in general ICU. General ICU patients classified according to renal impairment: 303 cases (no AKI) 60.6%, 74 cases (CKD) 14.8%, 55 cases (AKI) 11%, 38 cases (acute on top of CKD) 7.6%, 28 cases (ESRD) 5.6%, 2 cases (obstructive uropathy) 0.4%. Bimodal distribution of age in patients developed AKI at (18-30y) & (62-85y). 75 Toxicological cases, 3 developed AKI (2 organo phosphorus & 1 scorpion bite). The most common cause of AKI in our study was septic AKI 60% & among 128 cases of sepsis 32% not developed AKI/ 25.8% developed septic AKI 32% acute on top of CKD/10.2% ESRD. Mortality rate allover general ICU patients was 140/500 (28%) while allover AKI patients in general ICU 30/55(54%) and allover septic AKI 26/33(79%). Conclusion:AKI is a worsening problem, but its true incidence is in need of huge work, our work was 1 st up to our knowledge in Alexandria to check its incidence hence planning for better outcome.

Clinical Characteristics, Outcomes, and Prognosis among Cancer Patients with Acute Kidney Injury: A Single-Center Study at Sohag Cancer Center

“…Ahmed et al [18] reported that the incidences of risk, injury, failure, loss, and endstage renal disease were 25.9%, 29.24%, 15.56%, 17.92%, and 11.32%, respectively, in all departments of a university hospital in Cairo. Shafie et al [19] reported that 24% of ICU-admitted patients were classified as at risk,28.2%, and 47.8% as failing at Alexandria University Hospital.…”