Epidemiology and treatment of relative anemia in children with sickle cell disease in sub-Saharan Africa

Bello‐Manga, Halima; DeBaun, Michael R.; Kassim, Adetola A.

doi:10.1080/17474086.2016.1240612

Cited by 29 publications

(27 citation statements)

References 61 publications

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“…Sickle Cell Disease 10 Ware et al, 11 and Yawn et al 12 Data on availability in low-resource areas are from Bello-Manga et al 13 HbS denotes sickle hemoglobin.…”

Section: Pathoph Ysiol Ogymentioning

confidence: 99%

Sickle Cell Disease

2017

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“…Sickle Cell Disease 10 Ware et al, 11 and Yawn et al 12 Data on availability in low-resource areas are from Bello-Manga et al 13 HbS denotes sickle hemoglobin.…”

Section: Pathoph Ysiol Ogymentioning

confidence: 99%

Sickle Cell Disease

2017

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“…However, a few of the researchers interviewed mentioned that genomics tools are only sparingly available in the clinical setting in Africa and the most cited example was the diagnosis of sickle cell anaemia, a monogenic condition that is common in much of sub-Saharan Africa and responsible for high morbidity and mortality rates in infants and children [ 18 ]. The few interviewees who mentioned examples of the application of genomics in healthcare in Africa cited diagnosis and prenatal screening for sickle cell disease and Downs syndrome.…”

Section: Resultsmentioning

confidence: 99%

Genomics research in Africa and its impact on global health: insights from African researchers

Munung

Mayosi

Vries

2018

Glob. Health Epidemiol.

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Africa may be heading for an era of genomics medicine. There are also expectations that genomics may play a role in reducing global health inequities. However, the near lack of genomics studies on African populations has led to concerns that genomics may widen, rather than close, the global health inequity gap. To prevent a possible genomics divide, the genomics ‘revolution’ has been extended to Africa. This is motivated, in part, by Africa's rich genetic diversity and high disease burden. What remains unclear, however, are the prospects of using genomics technology for healthcare in Africa. In this qualitative study, we explored the views of 17 genomics researchers in Africa on the prospects and challenges of genomics medicine in Africa. Interviewees were researchers in Africa who were involved in genomics research projects in Africa. Analysis of in-depth interviews suggest that genomics medicine may have an impact on disease surveillance, diagnosis, treatment and prevention. However, Africa's capacity for genomics medicine, current research priorities in genomics and the translation of research findings will be key defining factors impacting on the ability of genomics medicine to improve healthcare in Africa.

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“…There is evidence that the pathophysiology of SCD has substantial nutritional implications including higher energy and nutrients requirements, nutrient de ciencies, and growth abnormalities. [13][14][15] It is theorized that a main driver of disease complications is higher rates of metabolic expenditure in individuals with SCD resulting from increased hematopoiesis, increased cardiac output, chronic in ammation, and related processes. [16,17] Since nutritional interventions could be a mechanism for addressing increased energy expenditure, attention to nutritional care is increasingly seen to be an important aspect of supportive management for patients with SCD, [18,19].…”

Section: Introductionmentioning

confidence: 99%

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

Nartey

Spector

Adu‐Afarwuah

et al. 2020

Preprint

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Background: Sickle cell disease (SCD), an inherited blood disorder, predominantly affects individuals in sub-Saharan Africa. While there are established studies that links its pathophysiology and nutritional status, the extent of research in this area involving African patients has not been previously described. This systematic review aimed to assess the nutrition-focused landscape of SCD studies in Africa, summarize findings, and highlight gaps in knowledge that could inform priority-setting for future research.Methods: The study was conducted using the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We included all original studies, conducted between 1995 and 2018, on nutritional status of individuals with SCD in Africa. ‘Nutritional status’ was defined by studies on dietary intake, measurements of growth/anthropometry, and nutritional biomarkers. Studies of anemia in non-SCD individuals and those with sickle cell traits were excluded. Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results: The search returned 366 articles from which 62 studies were included in the final analyses. Seventy percent of the investigations were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (50%), descriptive studies of macro- or micronutrient levels (35%), and interventional studies (15%). Findings consistently found growth impairment, especially among children and adolescents. Studies assessing macro- and micro-nutrients generally had small sample sizes and were exploratory in nature. Only two randomized placebo-controlled trials were identified, which measured the impact of fatty acid supplementation and lime juice on health outcomes. Conclusions: The findings reveal a moderate number of descriptive studies, with small sample size, that focused on various aspects of nutrition and sickle cell disease in African patients. There was a stark lack of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings of investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutritional-related interventions for patients with SCD in sub-Saharan Africa in order to promote optimal growth and improve health outcomes.

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Epidemiology and treatment of relative anemia in children with sickle cell disease in sub-Saharan Africa

Cited by 29 publications

References 61 publications

Sickle Cell Disease

Sickle Cell Disease

Genomics research in Africa and its impact on global health: insights from African researchers

Nutritional Perspectives on Sickle Cell Disease in Africa: A Systematic Review

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