Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study

Cong, Changsheng; Su, Chen; Sun, Yehuan; Xing, Ligang

doi:10.1007/s10147-020-01759-x

Cited by 14 publications

(29 citation statements)

References 19 publications

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“…Similar results were found in the Zheng series [11]. However, overall mortality of gastric location, in the multivariate was higher (HR = 2.821, 95% CI 1.265-6.292, p = 0.011) in our cohort compared to the Zheng study (HR = 2.47, 95% CI 1.73-3.50, p = 0.000) [11]. Small intestine location has the lowest overall mortality in our cohort compared to other locations.…”

Section: Discussionsupporting

confidence: 90%

“…Small intestine location has the lowest overall mortality in our cohort compared to other locations. This nding differs from the Zheng series in which the anal and colonic melanoma had the better overall survival than other GI melanoma subtypes [11].…”

Section: Discussioncontrasting

confidence: 89%

“…Primary gastric location was associated with the highest overall mortality and cancer speci c mortality in our cohort. Similar results were found in the Zheng series [11]. However, overall mortality of gastric location, in the multivariate was higher (HR = 2.821, 95% CI 1.265-6.292, p = 0.011) in our cohort compared to the Zheng study (HR = 2.47, 95% CI 1.73-3.50, p = 0.000) [11].…”

Section: Discussionsupporting

confidence: 87%

“…However, in the multivariate regression, chemotherapy and residential areas did not yield a higher overall or cancer speci c mortality. Also, Surgical resection of primary tumors was associated with lower mortality in the zheng series [11].…”

Section: Discussionmentioning

confidence: 88%

“…The study demonstrated that while the incidence of primary GI melanomas has been increasing since 1975, they are still rare and are detected at advanced stages [11]. However, there is still a paucity of conclusive data and a lack of adequately powered studies properly de ning epidemiology characteristics, survival outcomes, and prognostic factors of patients with Primary Gastrointestinal (GI) melanoma over the past decade alone.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

Bangolo

Fwelo

Trivedi

et al. 2022

Preprint

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Background: Primary malignant melanomas of the Gastric mucosa are uncommon. Most cases of Gastrointestinal (GI) melanomas are secondary, arising from metastasis at distant sites. GI melanomas have been associated with dismal prognosis, owing to their identification at more advanced stages. The purpose of this study is to investigate the clinical characteristics, survival outcomes, and prognostic factors of patients with primary GI melanoma in the past decade. Methods: A total of 399 patients diagnosed with Primary GI melanoma, between 2008 and 2017, were ultimately enrolled in our study by retrieving the Surveillance, Epidemiology, and End Results (SEER) database. We analyzed demographics, clinical characteristics, and overall mortality (OM) as well as cancer-specific mortality (CSM) of primary GI melanoma. Variables with a p value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors, with a hazard ratio (HR) of greater than 1 representing adverse prognostic factors.Results: From a sample of 399 primary GI melanomas, male gender (56.4%), age range 60-79 years (52.88%), non-Hispanic whites (70.18%), as well as annual income of $75,000+ yearly (30.33%) were the most represented. Crude analysis revealed higher overall mortality (OM) in age group 80+ (HR = 4.042, 95% CI 1.732 - 9.433, p = 0.001), stomach location of the tumor (HR = 3.261, 95% CI 1.658 - 6.417, p = 0.001), distant metastases (HR = 2.967, 95% CI 2.22 - 3.965, p=0 ), Nonmetropolitan counties not adjacent to a metropolitan area ( HR= 2.211, 95 % CI 1.253-3.9, p=0.006 ), and chemotherapy ( HR= 1.417, 95% CI 1.078-1.863, p=0.012). Crude analysis for Cancer specific mortality (CSM) also revealed higher mortality in the same groups. Multivariate cox proportional hazard regression analyses only revealed higher OM in age group 80+ (HR = 5.653, 95% CI 2.212 - 14.445, p=0), stomach location of the tumor (HR = 2.821, 95% CI 1.265 - 6.292, p = 0.011), and distant metastases (HR= 4.491, 95% CI 3.115-6.476, p=0). Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups.Conclusion: Primary GI melanoma is a rare entity. Only a few studies have been carried out in recent years to evaluate factors affecting the survival and mortality of primary GI melanoma. The paucity of data on primary GI melanoma governed the need of this study. In this population-based retrospective cohort study using the SEER database, we found that age at diagnosis, the primary site of the disease, and advanced disease at diagnosis were independent factors predicting poor prognosis. Furthermore, even surgical resection did not significantly impact the overall mortality or the cancer-specific mortality. This cohort paves the path for further prospective studies identifying individuals at an increased risk of primary GI melanomas, earlier and closer screenings in such individuals, and then evaluation of long-term prognosis in these patients as age and advanced disease were both independent risk factors predicting poor prognosis in our study.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

Bangolo

Fwelo

Trivedi

et al. 2022

Preprint

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Anorectal melanoma

Fastner

Hieken

McWilliams

et al. 2023

Journal of Surgical Oncology

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Anorectal melanoma is an aggressive mucosal melanoma subtype with a poor prognosis. Although recent advancements have been seen for cutaneous melanoma, the optimal treatment paradigm for management of anorectal melanoma is evolving. In this review, we highlight differences in the pathogenesis of mucosal versus cutaneous melanoma, new concepts of staging for mucosal melanoma, updates to surgical management of anorectal melanoma, and current data for adjuvant radiation and systemic therapy in this unique patient population.

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Anal and Perianal Preneoplastic Lesions

Loughrey,

Shepherd

2024

Gastroenterology Clinics of North America

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Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study

Cited by 14 publications

References 19 publications

Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

Epidemiology And Prognosis Factors Of Primary GI Melanoma In The Past Decade: Results From The SEER Database

Anorectal melanoma

Anal and Perianal Preneoplastic Lesions

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