Epidemiology and societal costs of gastroesophageal reflux disease and Barrett’s syndrome in Germany, Italy and Spain

Darbà, Josep; Kaskens, Lisette; Plans, Pedro; Elizalde, Jose Ignasi; Coma, Montserrat Serra; Cuomo, Rosario; Santoiemma, Luigi; Geldmacher, Jan

doi:10.1586/erp.11.5

Cited by 11 publications

(5 citation statements)

References 25 publications

(15 reference statements)

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“…Gastro-esophageal reflux disease (GERD) is the most frequent acid-related disease as of today and occurs at all ages from childhood to advanced age [1-3]. Pregnancy has long been recognized as a condition that predisposes to GERD and GERD symptoms are known to be common in pregnant women [4,5].…”

Section: Introductionmentioning

confidence: 99%

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

Malfertheiner

Kropf

et al. 2012

BMC Gastroenterol

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BackgroundSymptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30–80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of pregnancy. Furthermore current practice in medical care for GERD during pregnancy was assessed.MethodsWe performed a prospective longitudinal cohort study on 510 pregnant women (mean age 28.12, SD 5.3). Investigations for reflux symptoms where based on the use of validated reflux-disease questionnaire (RDQ). Additional information was collected about the therapy. A group of non-pregnant women (mean age 24.56, SD 5.7) was included as controls. Frequency and severity of reflux symptoms were recorded in each trimester of pregnancy.ResultsThe prevalence of GERD symptoms in pregnant women increased from the first trimester with 26.1 to 36.1% in the second trimester and to 51.2% in the third trimester of pregnancy. The prevalence of GERD symptoms in the control group was 9.3%.Pregnant women received medication for their GERD symptoms in 12.8% during the first, 9.1% during the second and 15.7% during the third trimester. Medications used >90% antacids, 0% PPI.ConclusionGERD symptoms occur more often in pregnant women than in non-pregnant and the frequency rises in the course of pregnancy. Medical therapy is used in a minority of cases and often with no adequate symptom relief.

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Section: Introductionmentioning

confidence: 99%

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

Malfertheiner

Kropf

et al. 2012

BMC Gastroenterol

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“…Euro Kosten aufgrund Abwesenheit vom Arbeitsplatz) führt und hohe Kosten im Gesundheitssystem (geschätzte Kosten 2011: 4,8 Mrd. Euro) verursacht [4,5].…”

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Die Acid Pocket: ein neues Ziel für die Behandlung der gastroösophagealen Refluxkrankheit

Sauter¹,

Fox²

2018

Z Gastroenterol

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ZusammenfassungDie gastroösophageale Refluxkrankheit stellt die häufigste Ursache für Symptome des oberen Gastrointestinaltrakts dar.Der Säure-Reflux in der postprandialen Phase ist der prädominante Faktor der gastroösophagealen Refluxkrankheit (gastro-esophageal Reflux disease, GERD) und führt zu Beschwerden wie Sodbrennen und saurem Aufstoßen. Die chronische Säureexposition des Ösophagus führt zudem zu Komplikationen wie der Refluxösophagitis, peptischen Stenosen, dem Barrett-Ösophagus oder dem Adenokarzinom.Das Ausmaß an mukosalen Schäden und Symptomen hängt von zwei Hauptfaktoren ab: (1.) dem Säuregehalt des Refluxats, welches primär von der gastralen Säureproduktion und der Verteilung der Säure im Magen abhängt sowie (2.) der Häufigkeit / Dauer an Refluxepisoden und der Stärke der Refluxbarriere am gastroösophagealen Übergang. Das Konzept der Acid Pocket ist ein Versuch, diese Faktoren in einem gemeinsamen Pathomechanismus zu vereinen.Die Acid Pocket beschreibt eine Ansammlung von Magensäure am gastroösophagealen Übergang in der postprandialen Phase und stellt ein wichtiges Reservoir für gastroösophageale Refluxepisoden dar. Die Acid Pocket ist sowohl bei Gesunden wie auch bei Refluxpatienten vorhanden. Insbesondere bei Patienten mit einer Hiatushernie und / oder einem hypotensiven unteren Ösophagus-Sphinkter kann sich die Acid Pocket aber über den gastroösophagealen Übergang hinaus in den distalen Ösophagus ausbreiten, was zu einer erhöhten Säureexposition insbesondere des distalsten Ösophagus-Abschnitts und somit Refluxbeschwerden führt.In den letzten Jahren wurde die Acid Pocket als mögliches Ziel von pharmakologischen und chirurgischen GERD-Therapien postuliert. Säurehemmende Medikamente wie z. B. Protonen-Pumpen-Inhibitoren reduzieren den Säuregehalt der Acid Pocket, wogegen Alginat-Substanzen, Prokinetika und die Fundoplikatio-Operation die Acid Pocket nach distal weg vom gastroösophagealen Übergang dislozieren.

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“…The direct costs associated with BE include the costs of the physician and hospital visits, the cost of endoscopic procedures and possible complications, such as stricture or perforation and the cost of anti-neoplastic medication for unresectable or persistent EAC (13).…”

Section: Introductionmentioning

confidence: 99%

Economic evaluation of endoscopic radiofrequency ablation for the treatment of dysplastic Barretts esophagus in Spain

et al. 2017

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Epidemiology and societal costs of gastroesophageal reflux disease and Barrett’s syndrome in Germany, Italy and Spain

Abstract: Costs due to poorly treated GERD with Barrett's esophagus represent a substantial burden for the healthcare systems of all three studied countries. Costs for employers owing to absenteeism or presenteeism of employees were low or no costs were found.

Cited by 11 publications

References 25 publications

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

Die Acid Pocket: ein neues Ziel für die Behandlung der gastroösophagealen Refluxkrankheit

Economic evaluation of endoscopic radiofrequency ablation for the treatment of dysplastic Barretts esophagus in Spain

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Epidemiology and societal costs of gastroesophageal reflux disease and Barrett’s syndrome in Germany, Italy and Spain

Abstract: Costs due to poorly treated GERD with Barrett's esophagus represent a substantial burden for the healthcare systems of all three studied countries. Costs for employers owing to absenteeism or presenteeism of employees were low or no costs were found.

Cited by 11 publications

References 25 publications

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy

Die Acid Pocket: ein neues Ziel für die Behandlung der gastroösophagealen Refluxkrankheit

Economic evaluation of endoscopic radiofrequency ablation for the treatment of dysplastic Barretts esophagus in Spain

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Economic evaluation of endoscopic radiofrequency ablation for the treatment of dysplastic Barretts esophagus in Spain