Epidemiology and risk factors for kidney cancer

Chow, Wong Ho; Dong, Linda M.; Devesa, Susan S.

doi:10.1038/nrurol.2010.46

Cited by 1,191 publications

(1,050 citation statements)

References 126 publications

(100 reference statements)

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“…14 Our finding that the sex ratio in kidney cancer incidence is stable across age groups, both before and after menopause, suggests that any female sex hormone related factors are unlikely to account for the difference in incidence between men and women. Other factors that may differ between men and women, such as immune surveillance, genome surveillance mechanisms, as well as the number of Xand sex chromosomes, could be investigated in terms of kidney cancer aetiology, especially and for other cancers which that display a strong and stable sex discrepancy in incidence.…”

Section: Main Reportmentioning

confidence: 74%

Variability of Sex Disparities in Cancer Incidence over 30 Years: The Striking Case of Kidney Cancer

Scélo

Chanudet

et al. 2018

European Urology Focus

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(DC Muller) Word count (main report): 8861,284 Word count (abstract): 186Take home message: Differences in cancer incidence between men and women are commonly attributed to different exposure to risk factors. This is unlikely to explain the observed sex ratio for kidney cancer, which is constant across age, time period, and geographical region. 1 AbstractIt is well established that men are at higher risk of most non sex-specific cancers than women, but there has been surprisingly little research investigating these differences. This is possibly because differences in exposure to established risk factors and hypothesized protection by female sex hormones are thought to account for the totality of the sex differences. These explanations remain somewhat speculative, as the magnitude of the sex ratio in cancer incidence has not been systematically studied, with no quantitative estimate of the variability of the sex ratio across countries, age groups, and periods of diagnosis. We analyzed analysed worldwide cancer incidence data for the years 1978 to 2007 in terms of sex-disparities, and explicitly quantified the variability in sex disparities by age, year, and geographical region. Our analysis highlights several cancer types for which suspected and commonly accepted factors are unlikely to fully explain the observed sex disparity. In particular, kidney cancer showed a 2 male cases for 1 female case incidence ratio that was constant by age, year, and region, suggesting that other factors than socio-cultural habits and health behaviours are responsible for this sex disparity.Patient summary: We quantified the difference in the incidence of various cancer types between men and women over thirty years across the world. While the trends for some cancers such as lung cancer clearly correlate with known variations in lifestyle habits, we found that the observed sex disparity for others like kidney cancer is unlikely to be explained by known risk factors. 2 Main reportDifferences in cancer incidence rates between men and women have been widely reported. 1,2 Men are at higher risk of most non sex-specific cancers, with the rare exceptions of thyroid and gallbladder cancers. There has been surprisingly little research investigating these differences. This is possibly because differences in exposure to established risk factors and hypothesized protection by female sex hormones are thought to account for the totality of the sex differences.These explanations remain somewhat speculative, as the magnitude of the sex ratio in cancer incidence has not been systematically studied, with previous reports providing no quantitative estimate of the variability of the sex ratio across countries, age groups, and periods of diagnosis.On kidney cancer incidence, interpretation of stratified estimates has been contradictory with the male predominance deemed as either "unresolved" 2 or "partly explained by established environmental risk factors" 1 . Such aA systematic evaluation of the variability could uncover patterns in sex-specific inc...

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Section: Main Reportmentioning

confidence: 74%

Variability of Sex Disparities in Cancer Incidence over 30 Years: The Striking Case of Kidney Cancer

Scélo

Chanudet

et al. 2018

European Urology Focus

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“…1,2 Approximately 80% of all renal carcinoma cases are currently classified as clear cell, papillary, or chromophobe subtypes with discrete molecular abnormalities characteristic for each group. [2][3][4][5][6][7] Rare subtypes have also been defined by the 2004 World Health Organization classification and include collecting duct, multilocular cystic, mucinous tubular and spindle cell, medullary, and Xp11.2 translocation-and neuroblastoma-associated carcinomas; each of these subtypes constitutes B1% of all primary kidney epithelial tumors and the three latter subtypes are diagnosed predominantly in children.…”

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confidence: 99%

Renal cell carcinoma with novel VCL–ALK fusion: new representative of ALK-associated tumor spectrum

et al. 2011

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Renal cell carcinoma represents a model for contemporary classification of solid tumors; however, unusual and unclassifiable cases exist and are not rare in children and young adults. The anaplastic lymphoma kinase (ALK) gene has recently been implicated in subsets of pulmonary, esophageal, breast, and colon cancers. These findings strengthen the importance of molecular classification of carcinomas across different organ sites, especially considering the evolving targeted anticancer therapies with ALK inhibitors. In the current study of six pediatric renal cell carcinomas, two cases exhibited structural karyotypic abnormalities involving the ALK locus on chromosomal band 2p23. Fluorescence in situ hybridization (FISH) studies were positive for an ALK rearrangement in one case, and subsequent 5 0 rapid amplification of cDNA ends analysis of this tumor revealed that the 3 0 portion of the ALK transcript encoding for the kinase domain was fused in frame to the 5 Keywords: ALK; FISH; fusion gene; renal cell carcinoma; translocation; VCL Renal cell carcinoma has an incidence of 209 000 cases per year and is responsible for 102 000 deaths worldwide annually. 1,2 Approximately 80% of all renal carcinoma cases are currently classified as clear cell, papillary, or chromophobe subtypes with discrete molecular abnormalities characteristic for each group. 2-7 Rare subtypes have also been defined by the 2004 World Health Organization classification and include collecting duct, multilocular cystic, mucinous tubular and spindle cell, medullary, and Xp11.2 translocation-and neuroblastoma-associated carcinomas; each of these subtypes constitutes B1% of all primary kidney epithelial tumors and the three latter subtypes are diagnosed predominantly in children. 8,9 Additional

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“…Incidence rates have been rising over past decades, with rates two times higher among men than women, and approximately 20% higher among African Americans (AA) compared to European Americans (EA) 2. Higher incidence rates, lower survival rates, and earlier age at diagnosis suggest that distinct factors may influence the development of kidney cancer within AA 3…”

Section: Introductionmentioning

confidence: 99%

“…Renal cell carcinoma (RCC) makes up approximately 90% of kidney cancer cases, and risk factors include cigarette smoking, obesity, hypertension, and alcohol 2, 4, 5, 6, 7, 8, 9, 10, 11. Racial differences in the distribution of several of these risk factors likely account for some of the excess risk observed in AA as compared to EA populations 4, 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma risk associated with lower intake of micronutrients

et al. 2018

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Kidney cancer incidence in African Americans (AA) is higher than among European Americans (EA); reasons for this disparity are not fully known. Dietary micronutrients may have a protective effect on renal cell carcinoma (RCC) development by inhibiting oxidative DNA damage and tumor growth. We evaluated whether any micronutrient associations differed by race in the US Kidney Cancer Study. 1142 EA and AA RCC cases and 1154 frequency‐matched controls were enrolled in a population‐based case‐control study between 2002 and 2007. Dietary micronutrient intake was derived from an interviewer‐administered diet history questionnaire. RCC risk associated with micronutrient intake was estimated using adjusted odds ratios from logistic regression comparing lower to highest quartiles of intake and sample weighting. Inverse associations with RCC risk were observed for α‐carotene, β‐carotene, lutein zeaxanthin, lycopene, vitamin A, folate, thiamin, vitamin C, α‐tocopherol, β‐tocopherol, γ‐tocopherol, and selenium. A trend for β‐cryptoxanthin was suggested among EA but not AA or the total sample (P‐interaction = .04). Otherwise, findings did not differ by race, gender, age, or smoking status. The increase in RCC risk associated with lower micronutrient intake is similar within AA and EA populations. A diet rich in sources of micronutrients found in fruits, vegetables, and nuts may help to reduce the overall risk of RCC.

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Epidemiology and risk factors for kidney cancer

Cited by 1,191 publications

References 126 publications

Variability of Sex Disparities in Cancer Incidence over 30 Years: The Striking Case of Kidney Cancer

Variability of Sex Disparities in Cancer Incidence over 30 Years: The Striking Case of Kidney Cancer

Renal cell carcinoma with novel VCL–ALK fusion: new representative of ALK-associated tumor spectrum

Renal cell carcinoma risk associated with lower intake of micronutrients

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