Epidemiology and Risk Factors for Cervical Cancer

Agustiansyah, Patiyus; Sanif, Rizal; Nurmaini, Siti; Irfannuddin, Irfannuddin; Legiran, None

doi:10.32539/bsm.v5i7.326

Cited by 10 publications

(8 citation statements)

References 6 publications

(14 reference statements)

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“…Therefore, cervical cancer screening was recommended to focus on high-risk groups, including women with more than three parity. 20 The optimal treatment for the early stages (stages IA1, IA2, and IB1) consisted of radical surgery or chemoradiation. In advanced-stage disease (IIB-IVB), where surgery was not possible, primary therapy was generally performed with chemoradiation or in combination with chemotherapy and radiation.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Rizal

Sanif²,

Novaliani

et al. 2022

Indones J Obstet Gynecol

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Abstract Objective: To determine the efficacy of neoadjuvant chemotherapy on changes of vitamin A serum in advanced cervical carcinoma patient. Method: A randomized clinical trial was performed in the Oncology Gynecology Polyclinic and Ward of Dr. Mohammad Hoesin General Hospital, Palembang from September 2019 to September 2020. There were 30 subjects of advanced cervical carcinoma. Vitamin A levels and tumor volume subjects were assessed before and 1 month after 3 cycles of NAC and analyzed using the Paired T Test and Wilcoxon test. The correlation between vitamin A levels and tumor volume was analyzed by using Spearman's Rho test. Data analysis was using SPSS version 22.0. Results: This study showed statistically not significant increase on vitamin A levels after 3 cycles of NAC chemotherapy (p=0.515). However, there was a significantly decrease in tumor volume after 3 cycles of NAC (p=0.000). In addition, there was a moderate negative correlation between tumor size and vitamin A (r=-0.475; p=0.008). Conclusion: It can be concluded that there was significantly decrease in tumor volume after 3 series NAC chemotherapy and the smaller tumor size, the higher level of vitamin A serum. Keywords: cervical cancer, neoadjuvant chemotherapy, randomized clinical trial, vitamin A, Abstrak Tujuan: Untuk mengetahui efektivitas kemoterapi neoadjuvan terhadap perubahan kadar serum vitamin A pada karsinoma servik stadium lanjut. Metode: Penelitian uji klinik tanpa pembanding telah dilakukan di Poliklinik dan Bangsal Onkologi Ginekologi RSUP Dr. Muhammad Hoesin Palembang sejak September 2019 hingga September 2020. Didapatkan 30 sampel karsinoma serviks stadium lanjut. Kadar vitamin A dan volume tumor dinilai sebelum dan 1 bulan setelah 3 siklus NAC dan dianalsis menggunakan uji Paired T Test dan Wilcoxon. Korelasi antara Kadar vitamin A dan volume tumor sampel dianalisis menggunakan uji Spearman Rho’s. Analisa data menggunakan SPSS versi 22.0. Hasil : Pada penelitian ini terdapat peningkatan tidak signifikan kadar vitamin A setelah kemoterapi (p = 0,515). Terdapat penurunan secara signifikan volume tumor sebelum dan sesudah kemoterapi NAC 3 seri (p = 0,000). Selain itu, didapatkan korelasi negatif sedang yang bermakna antara ukuran tumor dan kadar vitamin A ( r = -0,475 ; p = 0,008). Simpulan : Disimpulkan bahwa terdapat penurunan volume tumor setelah kemoterapi NAC 3 series dan semakin kecil ukuran tumor maka semakin tinggi kadar vitamin A dalam serum. Kata kunci: kanker serviks, kemoterapi neoadjuvan, uji klinik tanpa pembanding, vitamin A.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Rizal

Sanif²,

Novaliani

et al. 2022

Indones J Obstet Gynecol

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“…Indonesia sees an estimated 180,000 new cancer cases annually, with a staggering 75% mortality rate. 1 Various treatments have been implemented for cancer patients, including surgery, radiation, chemotherapy, and the use of herbal medicine. The advancement of herbal remedies involves rigorous testing through in vitro, in vivo, and in silico methods to scrutinize active compounds and their respective mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of quercetin and curcumin combination against HeLa cells line

Agitohutomo,

Edityaningrum,

Utari

et al. 2024

IJPTher

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Curcumin and quercetin combination are potential candidates for anticancer. Previous studies reported this combination active against several cancer cells including breast cancer, myeloid leukemia, and melanoma. However, the activity of this combination against cervical cancer has not been reported, yet. This study aimed to evaluate the cytotoxicity of the combination of curcumin and quercetin against HeLa and Vero cells. MTT assay was applied to evaluate cell growth inhibition. The inhibitory 50% concentration (IC50) of curcumin and quercetin on HeLa and Vero cells was determined and the selectivity index (SI) was then calculated. Combination index (CI) was calculated after evaluation of the cytotoxicity of the curcumin and quercetin combination at various concentration of 1 IC50, ½ IC50, and ¼ IC50. The IC50 of the curcumin against the HeLa and Vero cells were 26.57 ± 2.00 μM and 73.89 ± 12.93 μM with a SI of 2.78. Whereas the IC50 of the quercetin against the HeLa and Vero cells were 149.52 ± 21.09 μM and 1094.47 ± 15.68 μM with a SI of 7.32. The CI of combinations of curcumin and quercetin at concentrations of ¼ IC50 was 0.78 indicating a mild-moderate synergistic effect, whereas the combination at a concentration of 1 IC50 or ½ IC50, the CI value was >0.9 indicating an antagonistic effect.

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“…Globocan in 2020 states that new cases of cervical cancer in women in the world are 604,127 cases and deaths from cervical cancer are 341,831 cases (Sung et al, 2021). Countries in Asia such as China, Indonesia and India have a major contribution to the incidence of cervical cancer (Agustiansyah et al, 2021). This is because the country has a large population.…”

Section: Introductionmentioning

confidence: 99%

Perceptions, Knowledge, Attitudes, and Cervical Cancer Prevention Behavior Among Health and Non-Health Scholar

2023

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Background: Cervical cancer is still a leading cause of death fourth in women in the world and in Indonesia it is the second leading cause of death in women after breast cancer, including in the adolescent group. This study aimed to explore distinguish perception, knowledge, attitude, and cervical cancer prevention among health and non-health scholars in Indonesia. Method: Used an analytical observational design with a cross-sectional approach. The sample in this study were 364 students, consisting of 168 health students and 196 non-health scholars. Data analysis used univariate and bivariate analysis using independent t tests. Results: there are differences in perceptions of cervical cancer prevention between health and non-health students with an average value of 17.34 (2.11) for health students, while for non-health students 16.80 (1.94) with p_value 0.012, including variables knowledge and attitude differences in cervical cancer prevention (in health students the average knowledge = 11.95, 0.95; the average attitude = 21.57, 2.08, while in non-health students the average knowledge = 10.81, 1.06; the average attitude = 20.62, 2.25). The p value for the attitude variable is 0.000 and the knowledge variable is 0.001. Conclusion: there are differences in perceptions, knowledge, and attitudes towards cervical cancer prevention in health and non-health scholars, Indonesia.

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Epidemiology and Risk Factors for Cervical Cancer

Cited by 10 publications

References 6 publications

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

The Efficacy of Chemotherapy in Advanced-Stage Cervical Cancer on Vitamin A Serum

Cytotoxicity of quercetin and curcumin combination against HeLa cells line

Perceptions, Knowledge, Attitudes, and Cervical Cancer Prevention Behavior Among Health and Non-Health Scholar

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