Epidemiology and risk factors for mortality in bloodstream infections: A single-center retrospective study in Japan

Hattori, Hiromichi; Maeda, Masako; Nagatomo, Yasuhiro; Teratani, Takuma; Niki, Yoshihito; Naito, Yohei; Sasaki, Takeshi; Ishino, Kozo

doi:10.1016/j.ajic.2018.06.019

Cited by 47 publications

(51 citation statements)

References 24 publications

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“…to those with susceptible bacteria. The dominant risk factor for 30-day all-cause mortality associated with BSI was comorbidity, which agrees with previous studies [3,32,33]. The incidence of BSI and associated 30-day all-cause mortality per 100,000 hospital admissions increased over the study period by 66%, and 17% respectively which is consistent with the results of other studies [4,34,35].…”

Section: Plos Onesupporting

confidence: 92%

“…Surprisingly, multivariable analyses showed a lower 30-day all-cause mortality among patients with BSI caused by AMR bacteria including ESBL, MRSA and VRE without MDR, compared to those with susceptible bacteria [54], while other studies have reported the opposite [32,55,56]. Further studies are needed to explain the lower mortality rate found in this group.…”

Section: Plos Onementioning

confidence: 61%

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Low incidence of antibiotic-resistant bacteria in south-east Sweden: An epidemiologic study on 9268 cases of bloodstream infection

et al. 2020

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The aim of this study was to investigate the epidemiology of bloodstream infections (BSI) in a Swedish setting, with focus on risk factors for BSI-associated mortality. Methods A 9-year (2008-2016) retrospective cohort study from electronic records of episodes of bacteremia amongst hospitalized patients in the county of Ö stergö tland, Sweden was conducted. Data on episodes of BSI including microorganisms, antibiotic susceptibility, gender, age, hospital admissions, comorbidity, mortality and aggregated antimicrobial consumption (DDD /1,000 inhabitants/day) were collected and analyzed. Multidrug resistance (MDR) was defined as resistance to at least three groups of antibiotics. MDR bacteria and MRSA, ESBL-producing Enterobacteriaceae, vancomycin-resistant enterococci not fulfilling the MDR criteria were all defined as antimicrobial-resistant (AMR) bacteria and included in the statistical analysis of risk factors for mortality Results In all, 9,268 cases of BSI were found. The overall 30-day all-cause mortality in the group of patients with BSI was 13%. The incidence of BSI and associated 30-day all-cause mortality per 100,000 hospital admissions increased by 66% and 17% respectively during the nineyear study period. The most common species were Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae and Enterococcus faecalis.

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Section: Plos Onesupporting

confidence: 92%

Section: Plos Onementioning

confidence: 61%

Low incidence of antibiotic-resistant bacteria in south-east Sweden: An epidemiologic study on 9268 cases of bloodstream infection

et al. 2020

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“…CBSIs occur in up to 10% of all bloodstream infections in hospitalized patients [313,314,315], and the mortality rate is about 40% [316,317]. Normally, this mortality is higher than in bloodstream infections involving bacteria [326,327]. Risk factors for CBSIs include critically ill patients in intensive care units, DM, immunosuppressive states, mechanical ventilation, neutropenia, recent surgical procedures, and prematurity [315,318,319].…”

Section: Candidiasis and Dmmentioning

confidence: 99%

Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

201

161

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Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the patient. This review aims to discuss the latest studies regarding the occurrence of candidiasis on DM patients and the pathophysiology and etiology associated with these co-morbidities. A comprehensive review of the literature was undertaken. PubMed, Scopus, Elsevier’s ScienceDirect, and Springer’s SpringerLink databases were searched using well-defined search terms. Predefined inclusion and exclusion criteria were applied to classify relevant manuscripts. Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia. The conclusion is that, for these patients, the hospitalization periods have increased and are commonly associated with the prolonged use of indwelling medical devices, which also increase the costs associated with disease management.

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“…Similarly, Japan has shown a varying pathogenic profile of BSIs, with E. coli, S. aureus, Streptococcus spp., and Klebsiella spp. as the common organisms [24]. These differing reports on BSI-causing pathogens explain the variations in different regions.…”

Section: Plos Onementioning

confidence: 99%

Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia

Bandy

Almaeen

2020

PLoS ONE

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Background The pathogenic spectrum of bloodstream infections (BSIs) varies across regions. Monitoring the pathogenic profile and antimicrobial resistance is a prerequisite for effective therapy, infection control and for strategies aimed to counter antimicrobial resistance. The pathogenic spectrum of BSIs in blood cultures was analysed, focusing on the resistance patterns of Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae, in Aljouf region. Methods This descriptive cross-sectional study analysed the culture reports of all non-duplicate blood samples collected from January 1 to December 31, 2019. Antibiograms of A. baumannii, E. coli, and K. pneumoniae were analysed for antibiotic resistance. The frequency and percentages of multi-drug, extensively-drug, pan-drug and carbapenem resistance were calculated. Results Of the 222 bloodstream infections, 62.2% and 36.4% were caused by gram-negative and gram-positive bacteria, respectively. Most BSIs occurred in patients aged �60 years (59.5%). Among the 103 isolates of the studied Gram-negative bacteria (GNB), 47.6%, 38.8%, and 2.9% were multi-drug, extensively drug and pan-drug resistant respectively. 46% of K. pneumoniae isolates were carbapenemase producers. Resistance to gentamycin, 1 st-4 th generation cephalosporins, and carbapenems was observed for A. baumannii. More than 70% of E. coli isolates were resistant to 3 rd-and 4 th-generation cephalosporins. Klebsiella pneumoniae presented a resistance rate of >60% to imipenems.

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Epidemiology and risk factors for mortality in bloodstream infections: A single-center retrospective study in Japan

Abstract: This study reported epidemiology and antimicrobial resistance data of BSIs in Japan and identified several risk factors associated with 30-day mortality. National surveillance of BSIs is required in Japan for comparison with other countries.

Cited by 47 publications

References 24 publications

Low incidence of antibiotic-resistant bacteria in south-east Sweden: An epidemiologic study on 9268 cases of bloodstream infection

Low incidence of antibiotic-resistant bacteria in south-east Sweden: An epidemiologic study on 9268 cases of bloodstream infection

Candida sp. Infections in Patients with Diabetes Mellitus

Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia

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