Epidemiology and prospects for prevention of rotavirus disease in India

Kahn, Geoffrey; Fitzwater, Sean; Tate, Jacqueline E.; Kang, Gagandeep; Ganguly, Nirmal Kumar; Nair, G. Balakrish; Steele, Duncan; Arora, Rashmi; Chawla‐Sarkar, Mamta; Parashar, Umesh D.; Santosham, Mathuram

doi:10.1007/s13312-012-0076-7

Cited by 54 publications

(62 citation statements)

References 57 publications

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“…5e7 Advances in hygiene and sanitation have reduced the predominance of the other gut pathogens, while leaving rotavirus incidence almost unaffected. 8 Rotavirus vaccines are being projected as a solution to this problem. Availability of efficacious rotavirus vaccines has warranted extensive epidemiological studies on rotavirus diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of rotavirus infection in children below two years presenting with diarrhea

John

Devgan

Mitra

2014

Medical Journal Armed Forces India

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DiarrheaPrevalence Children a b s t r a c t Background: Rotavirus is a common cause of diarrhea in children. There is a need for data on prevalence of rotavirus diarrhea especially in our setting. This study was carried out to determine the prevalence of rotavirus infection in children upto two years presenting with diarrhea and to ascertain factors associated with rotavirus infection in them.Methods: A cross sectional observational study was carried out to determine the prevalence of rotavirus infection amongst children less than 2 years presenting with diarrhea. The clinical profile of the children was analyzed along with detection of rotavirus antigen in stool.Results: A total of 250 children with diarrhea were included in the study. The Male: Female ratio was 0.97:1. We found 24% children presenting with diarrhea to be positive for rotavirus antigen. 78.3% of children with rotaviral diarrhea were in the age group of 6e15 months. There was a significant association between type of feeding and rotavirus diarrhea with reduced prevalence while on exclusive breast-feeding. Though only 10.4% of children with rotavirus diarrhea had severe dehydration, 61.5% of children with severe dehydration were positive for rotavirus. Conclusion:Rotavirus diarrhea caused substantial morbidity in our study population. The rotavirus positivity in these children was 24% and there was a significant association of rotavirus infection with type of feeding and severity of dehydration.ª 2014, Armed Forces Medical Services (AFMS). All rights reserved.

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Section: Introductionmentioning

confidence: 99%

Prevalence of rotavirus infection in children below two years presenting with diarrhea

John

Devgan

Mitra

2014

Medical Journal Armed Forces India

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“…In previously published studies also, G1P [8] was the most prevalent genotype identified in other parts of India including South India. [15][16][18][19][20] G1P [4], G1P [6] and G2P [4] were identified in 7.34%, 4.59% and 6.42% specimens, respectively. In previous studies from India, G2P [4] was found to be one of the predominant strains.…”

Section: Discussionmentioning

confidence: 99%

“…In India, diversity of rotavirus strains varies geographically, with G1 and G2 as the predominant strains. [17][18][19][20] G9P [4] and G9P [8] were detected in 3.70% and 1.83% of the specimens, respectively. G12P [6] and G12P [8] were detected in 3.70% and 0.91% of the specimens tested, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of group A rotavirus genotype G1P[8] in Chennai, South India

Daga

Jamuna

Sadullah

et al. 2016

Int J Contemp Pediatr

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“…Regarding seasonality, some studies in India have found no association between rotavirus infection and the time of year 13,21 .Other studies have observed an increase in rotavirus-associated diarrhea during the winter months, October-February, throughout the country 12,22,23 .…”

Section: Severity Of Rotavirus Diarrhoea Was Shown Inmentioning

confidence: 99%