Epidemiology and Prognostic Implications of Contrast-Induced Nephropathy

McCullough, Peter A.; Adam, Andy; Becker, Christoph R.; Davidson, Charles J.; Lameire, Norbert; Stacul, Fulvio; Tumlin, James A.

doi:10.1016/j.amjcard.2006.01.019

Cited by 383 publications

(318 citation statements)

References 99 publications

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“…Using up-to-date precise AKI reporting criteria that included urine output measurements, we recently documented that elective EVAR can lead to AKI in 18.8% of patients (in a cohort of 149 patients), which was associated with mortality and cardiovascular morbidity over the medium-term (7). Further to EVAR, AKI after various types of surgical or radiological intervention has been independently associated with higher morbidity, prolonged length of hospital stay, cost, short-term mortality (8)(9)(10), as well as decreased long-term survival (11)(12)(13)(14)(15). As a result, preventing AKI is crucial in improving outcome, especially in populations at high-risk, such as those undergoing EVAR.…”

Section: Introductionmentioning

confidence: 99%

Renal Function is the Main Predictor of Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair

Saratzis

Nduwayo

Sarafidis

et al. 2016

Annals of Vascular Surgery

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Section: Introductionmentioning

confidence: 99%

Renal Function is the Main Predictor of Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair

Saratzis

Nduwayo

Sarafidis

et al. 2016

Annals of Vascular Surgery

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“…However, it can be stated that the general incidence is about 7%. 1 Many studies reported that CIN has been associated with high in-hospital morbidity and mortality. 2,3 This high incidence and morbidity and mortality rate has made clinicians more aware of this catastrophic complication and increased the need for new strategies and new drugs to avoid it.…”

Section: Introductionmentioning

confidence: 99%

Does Nebivolol Prevent Contrast‐Induced Nephropathy in Humans?

Günebakmaz

Kaya

Koç

et al. 2012

Clinical Cardiology

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Background:An experimental study showed that nebivolol is an effective agent in contrast‐induced nephropathy (CIN) prophylaxis.Hypothesis:We hypothesized that prophylactic nebivolol use had protective effects on renal function in human beings subjected to iodinated contrast agent since it has vasodilatory effect and antioxidant properties.Methods:The present study enrolled 120 patients scheduled for coronary angiography and ventriculography. All patients were hydrated with intravenous isotonic saline. The patients in group I received 600 mg N‐acetylcysteine every 12 hours for 4 days. The patients in group II received 5 mg nebivolol every 24 hours for 4 days. The patients in group III were only hydrated. The primary endpoint was the occurrence of CIN. The secondary endpoint was the change in serum creatinine (Cr) levels at 2 days and 5 days after the contrast exposure.Results:Nine (22.5%) patients in group I developed CIN, as did 8 patients (20.0%) in group II and 11 patients (27.5%) in group III (P = 0.72). Changes in mean Cr level from baseline to day 2 were not statistically significant in all groups. However, we detected a statistically significant increase in mean Cr levels at day 5 compared with baseline levels in group I and group III (from 1.42 ± 0.13 to 1.52 ± 0.26, p2 = 0.02; and from 1.43 ± 0.14 to 1.55 ± 0.30, p2 = 0.01, respectively). Although an increase was detected in mean Cr level from baseline to the 5‐day Cr level in group II, this did not reach statistical significance (from 1.40 ± 0.12 to 1.48 ± 0.23, P = 0.06).Conclusions:Pretreatment with nebivolol is protective against nephrotoxic effects of contrast media. © 2012 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose.

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“…Parenteral administration of iodine-containing radio contrast media in intensive care unit (ICU) patients may be associated with development of contrast-associated acute kidney injury (CA-AKI) [1][2][3]. We prefer to use the term ''associated'' instead of ''contrast-induced'' AKI because in the specific ICU setting development of AKI is most probably heterogeneous in origin [4].…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of CA-AKI ranges between 0 and 50% depending on the case mix and the definition for CA-AKI that is used [1,3,4,14,15]. The most commonly used definition is an increase of serum creatinine C0.5 mg/dL or C25% from baseline, assessed 48-72 h after the procedure [16].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of contrast-associated acute kidney injury in ICU patients: a retrospective cohort analysis

et al. 2011

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Intensive care unit (ICU) patients frequently undergo contrast-enhanced radiographic examinations, which carries a risk for development of contrast-associated acute kidney injury (CA-AKI). Data on this in ICU patients are scarce. The aim of this study was therefore to evaluate the epidemiology and short- and long-term outcomes of CA-AKI in ICU patients. A retrospective single-centre cohort study covering the period 1 March 2004 to 31 December 2008 on ICU patients who underwent a radiography examination with parenteral administration of iodinated radio contrast media was conducted. Data analysis included univariate and multivariate analyses of patients with and without CA-AKI. A total of 787 ICU patients were included in the study. CA-AKI occurred in 128 (16.3%) and was associated with higher need for RRT [30 (4.6%) vs. 21 (16.4%), p < 0.001], worse kidney function at discharge, longer length of ICU and hospital stay, and higher 28-day and 1-year mortality [28-day: 86 (13.1%) vs. 46 (35.9%), p < 0.001, and 1-year: 158 (24.0%) vs. 71 (55.5%), p < 0.001]. Higher serum creatinine, lower mean arterial pressure, and administration of diuretics and vasoactive therapy were associated with development of CA-AKI in multivariate analysis. After correction for confounders we found that CA-AKI was associated with 28-day mortality in this cohort of ICU patients (odds ratio = 2.742, 95% confidence interval 1.374-5.471). CA-AKI occurred in one out of six ICU patients who underwent a contrast-enhanced radiography examination and was associated with both short-and long-term worse outcomes such as need for RRT, worse kidney function at discharge, increased length of stay in the ICU and hospital, and mortality

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Epidemiology and Prognostic Implications of Contrast-Induced Nephropathy

Cited by 383 publications

References 99 publications

Renal Function is the Main Predictor of Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair

Renal Function is the Main Predictor of Acute Kidney Injury after Endovascular Abdominal Aortic Aneurysm Repair

Does Nebivolol Prevent Contrast‐Induced Nephropathy in Humans?

Epidemiology of contrast-associated acute kidney injury in ICU patients: a retrospective cohort analysis

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