Epidemiology and prognosis of subungual melanoma in 34 Japanese patients

Kato, Taizo; Suetake, Takaki; Sugiyama, Yoshihiro; Tabata, Noriko; Tagami, Hachiro

doi:10.1046/j.1365-2133.1996.19754.x

Cited by 78 publications

(72 citation statements)

References 16 publications

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“…Finally, melanomas considered to be nonphotoinduced (NPIM) include (i) melanomas located on nonphotoexposed sites (sun-protected skin areas or mucous localisations) and (ii) subungual and acral lentiginous melanomas that are considered to be particular subtypes of melanoma, because, in contrast to other subtypes, ultraviolet irradiation is not a major factor in their development (Kato et al, 1996;Saida, 2001), thus suggesting genetic factors in their onset.…”

mentioning

confidence: 99%

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma

et al. 2004

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Germline anomalies of the INK4a-ARF and Cdk4 genes were sought in a series of 89 patients suspected of having a genetic predisposition to melanoma. Patients were selected based on the following criteria: (a) familial melanoma (23 cases), (b) multiple primary melanoma (MPM; 18 cases), (c) melanoma and additional unrelated cancers (13 cases), (d) age at diagnosis less than 25 years (21 cases), and (e) nonphoto-induced melanoma (NPIM; 14 cases). Mutations of INK4a-ARF and Cdk4 were characterised by automated sequencing, and germline deletions of INK4a-ARF were also examined by real-time quantitative PCR. Seven germline changes of INK4a-ARF, five of which were novel, were found in seven patients (8%). Four were very likely to be pathogenic mutations and were found in three high-risk melanoma families and in a patient who had a pancreatic carcinoma in addition to melanoma. Three variants of uncertain significance were detected in one MPM patient, one patient o25 years, and one NPIM patient. No germline deletion of INK4a-ARF was found in 71 patients, and no Cdk4 mutation was observed in the 89 patients. This study confirms that INK4a-ARF mutations are infrequent outside stringent familial criteria, and that germline INK4a-ARF deletions are rarely involved in genetic predisposition to melanoma.

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confidence: 99%

Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma

et al. 2004

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“…The pigmentation of the surrounding nail tissue, called Hutchinson's sign, paired with nail lifting is indicative of melanoma [22]. The continued linear growth of dark bands subungually, or longitudinal melanonychia, is indicative of melanoma, especially if it is greater than 3 mm wide or wide at the base with distal tapering [23,37]. Some studies report an increased risk of melanoma secondary to trauma, however, the Cohen study reported trauma as an inciting factor in only 10 % of patients [11].…”

Section: Malignant Melanomamentioning

confidence: 99%

Subungual tumors

Dooley

Kindt

Baratz

2012

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A 60-year-old man described a 15-year history of intermittent drainage from beneath the nail plate of his left long finger. The drainage began years after the subject sustained an injury in which a thorn became embedded beneath the nail. The patient had performed a number of self-debridements over the years. He had taken oral antibiotics on multiple occasions. In the 6 months prior to presentation, the drainage became more constant along with pain and erythema. On presentation, the nail plate had a central, 2-mm defect with granulomatous tissue underneath and longitudinal melanonychia. The nail plate was tender and minimal serosanginous drainage could be expressed. The remainder of the finger and nail complex appeared normal. Radiographs of the finger were normal.

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“…The incidence of amelanotic melanoma in all melanomas is low, although the subungual region seems to be an area of predilection for amelanotic melanoma in 15 to 25% of cases 4,6 . The lack of pigmentation causes the clinical appearance to be nonspecific for melanoma.…”

Section: Case Reportmentioning

confidence: 99%

“…Approximately 15 to 25% of cases of subungual melanoma are amelanotic. The lack of pigmentation of the lesion may cause misdiagnosis and aggravate its poor prognosis [4][5][6] . We herein report on a case of amelanotic subungual melanoma extended to the adjacent skin in a 36-year-old Korean woman.…”

Section: Introductionmentioning

confidence: 99%